20.21%
improvement in eye-area radiance
Week 8
Expert grading, n=31; p<0.001.
SeneGenceReview8-Week Independent Eye-Area Study
SeneGence® EyeCrème
Greater radiance and improved-looking crow’s feet by Week 8.
Independent expert grading documented progressive improvement in eye-area radiance and crow’s-feet appearance, supported by strong participant perceptions of brighter, smoother, more rested-looking eyes.
31 completed8 weeksExpert grading + participant perceptionTested as SGF19112-03
87.10%
of participants improved in radiance
Week 8
Expert grading, n=31.
83.87%
said lines and wrinkles looked diminished
Week 8
Participant perception, n=31.
SeneGenceReviewClinical Results
Visible eye-area results
Versus baseline, expert-graded radiance improved 14.51% at Week 6 and 20.21% at Week 8.
Radiance - expert-graded mean improvement20.21%
Week 8, n=31; p<0.001.
Crow’s-feet appearance - expert-graded mean improvement9.15%
Week 8, n=31; p<0.001.
Participants who improved in radiance87.10%
Week 8, n=31.
80.65%said the eye area looked more rested.
77.42%said the eye area looked brighter.
77.42%said the eye area looked smoother.
77.42%said the eye area looked more awake.
Two complementary lenses
Expert grades quantify visible appearance; participant percentages report self-perception. These results are presented separately so each claim keeps its proper evidence source.
SeneGenceReviewClinical Results
Technical study record
The strongest substantiation is expert-graded visible appearance.
Independent laboratoryValidated Claim Support, LLC
Study / reportCS211048 / RE211048.V02
Tested articleSeneDerm Eye Creme AGE Defense SGF19112-03
Design8-week single-arm baseline comparison
Population32 enrolled; 31 completed; ages 48-70
VisitsBaseline, immediate, Week 6, Week 8
EvidenceExpert grading, Corneometer, Glossymeter, Visioscan, photography, questionnaire
Source date13 July 2022
Expert-graded appearance (n=31)
| Expert endpoint | Week 6 | Week 8 |
|---|---|---|
| Radiance | 14.51% improvement; 67.74% improved; p<0.001 | 20.21% improvement; 87.10% improved; p<0.001 |
| Crow’s-feet appearance | 5.49% improvement; 29.03% improved; p=0.001 | 9.15% improvement; 41.94% improved; p<0.001 |
Lower grades indicate improvement.
Scope of instrumental support
| Instrument endpoint | Finding | Interpretation |
|---|---|---|
| Corneometer hydration | Immediate -9.11%; p=0.049; Week 6 -5.98%; p=0.248; Week 8 -1.71%; p=0.734 | Did not substantiate improved hydration |
| Glossymeter shine | Immediate -29.62%; p<0.001 | Did not substantiate increased shine |
| Visioscan SEw wrinkles | Week 6 +7.63%; p=0.452; Week 8 -2.92%; p=0.741 | Week 8 favorable direction; not statistically significant |
The report therefore leads with expert-graded radiance and crow’s-feet appearance, not instrument hydration, shine, or wrinkle claims.
Study application
Thirty-one participants completed the study. Results apply to SeneDerm Eye Creme AGE Defense SGF19112-03 under the reported eight-week study design.
SeneGenceReviewTechnical Evidence
Independent laboratory evidence
Original source pages follow.
View the complete source record.
Selected original VCS pages follow, preserving the signed study summary, methods, aggregate results, conclusion, and Quality Assurance record while excluding participant-level material.
The complete PDF pairs this consumer summary with the selected independent laboratory source pages.
Open full PDF + laboratory sourceLaboratoryValidated Claim Support, LLC
Study / reportCS211048 / RE211048.V02
Source date13 July 2022
AuthenticationDigital investigator + QA signatures
Source authentication
The final report contains dated digital Quality Assurance and Principal Investigator signatures dated 13 July 2022.
Independent laboratory source pages are included in the complete PDF. Participant-identifying information has been removed where indicated; aggregate findings are unchanged.