Peptides at Work

A peptide is a short chain of amino acids — the building blocks of keratin in hair and collagen in skin. They're all over your kit.

Amino acids are the alphabet; a few linked make a peptide, hundreds make a protein like keratin (hair) or collagen (skin). Chemists prize short peptides because their low molecular weight lets them be delivered into the skin's surface — and for how they help skin and hair LOOK: smoother, firmer, fuller-looking.

SeneGence uses a family across skincare, hair, brow, lash and lip. Your job: know which peptide is in which product, and to a client, describe it by appearance, not biology.

Terminology: a peptide is a short amino-acid chain; "di/tri/tetra/penta/hexa/hepta" tells you how many amino acids it carries (Tripeptide-1 = 3, Tetrapeptide-17 = 4, Pentapeptide = 5, Hexapeptide-40 = 6, Heptapeptide-15 = 7).

Acyl prefixes — Palmitoyl (C16), Myristoyl (C14), Acetyl, Caprooyl — name a fatty-acid or acetyl group attached to improve stability and how the ingredient is delivered into the skin's surface (the low-molecular-weight, smallest-first logic of the whole regimen); "Sh-" (e.g. Sh-Polypeptide-9) denotes a synthetic-human-sequence peptide made by fermentation.

On the INCI label you'll therefore see names like Palmitoyl Tripeptide-1, Acetyl Tetrapeptide-3 or Myristoyl Pentapeptide-17 — not the marketing trade names. Know the delivery science internally, but to a client frame everything as appearance — how a peptide helps skin and hair LOOK, never as a physiological action.

The name in the marketing isn't the name on the label. "Capixyl" is the brand; "Acetyl Tetrapeptide-3" is the INCI. Learn to read both.

Suppliers sell peptides under trade names — Capixyl, Matrixyl 3000 OS, ChroNOline, ReneSeed, AccessPEP CTP, SenePeptide. The legal label uses INCI names — Acetyl Tetrapeptide-3, Caprooyl Tetrapeptide-3, and so on. Same molecule, two names; the verified peptide list is your decoder ring.

Two twists: one INCI can wear two trade names (Heptapeptide-15 Palmitate = X50PureWhite and X50 Hyalufiller Powder), and one house name can cover different INCIs by product (SenePeptide).

INCI (International Nomenclature of Cosmetic Ingredients) is the standardized name that must appear on the label; trade names are supplier or brand IP used in marketing and training.

Verified pairings from the peptide list: Capixyl = Acetyl Tetrapeptide-3; Matrixyl 3000 OS = Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7; ReneSeed = Nicotiana Benthamiana Hexapeptide-40 + Sh-Polypeptide-76; ChroNOline = Caprooyl Tetrapeptide-3; AccessPEP CTP = Bis(Tripeptide-1) Copper Acetate; X50PureWhite and X50 Hyalufiller Powder = Heptapeptide-15 Palmitate; V-4s = Acetyl Tetrapeptide-2; TEGO PEP 4-17 = Tetrapeptide-17; KOLLAREN = Tripeptide-1; SYN-STAR = Dipeptide Diaminobutyroyl Benzylamide Diacetate; Maxi-Lip = Palmitoyl Tripeptide-1; SenePeptide / WideLash / Sympeptide XLash = Myristoyl Pentapeptide-17.

When a client reads their carton, they'll see the INCI column — not the trade name — so being able to translate both directions is what makes you sound like you actually know the formula.

SenePeptide isn't on the label — it's SeneGence's name for Myristoyl Pentapeptide-17, the keratin peptide in HairCovery and LashExtend.

SenePeptide® is a SeneGence house name for Myristoyl Pentapeptide-17 — verified in HairCovery Conditioner and Hairspray, LashExtend and Nail Extend, usually paired with Capixyl. Approved framing: a keratin-supporting peptide for the appearance of fuller-, stronger-looking hair and lashes.

Caveat: it's a marketing name, not an INCI, and maps to a different peptide in the Translucent Loose Powder — so confirm by product. It supports how hair and lashes LOOK; it does not grow hair.

INCI: Myristoyl Pentapeptide-17 — a pentapeptide (5 amino acids) with a myristoyl (C14) tail; supplier names WideLash and Sympeptide XLash. Verified products from the peptide list: HairCovery Conditioner (with Capixyl), HairCovery Hairspray (with Capixyl), LashExtend Overnight Eyelash Serum (with Capixyl + WideLash) and Nail Extend.

Approved appearance phrasings from the education catalogue: "keratin-supporting peptide for strength," "supports the appearance of keratin structure for fuller-looking lashes," "keratin-building peptide for strength and fullness." Disambiguation: the peptide map and language report both note SenePeptide® is also used to label Acetyl Hexapeptide-8 in the Translucent Loose Powder — a different active — which is exactly why you confirm by product.

Red lines: never say it "stimulates follicles," "increases hair/lash growth," or "regenerates" — all flagged drug claims. It is a cosmetic that supports the look of fuller, stronger-looking hair and lashes.

One peptide runs through HairCovery, BrowSense, Clear Brow Gel and LashExtend: Capixyl — INCI Acetyl Tetrapeptide-3.

Capixyl™ = Acetyl Tetrapeptide-3, the franchise peptide across the hair, brow and lash range: HairCovery Shampoo, Conditioner and Serum, HairCovery Hairspray, BrowSense Brow Building Cream (every shade), Clear Brow Gel and LashExtend.

Approved: "supports the appearance of longer lashes," "supports the look of a fuller lash line." A ready hook: "46% saw fuller-looking brows in a study" — perception-framed, not a growth claim. Never say it blocks a hormone or stimulates the growth phase.

INCI: Acetyl Tetrapeptide-3 (an acetylated tetrapeptide, 4 amino acids). Verified products from the peptide list: HairCovery Thickening & Volumizing Shampoo, HairCovery Conditioner, HairCovery Strengthening & Thickening Hair Serum, HairCovery Hairspray, BrowSense Long-Lasting Brow Building Cream (Auburn, Black Brown, Blonde Taupe, Deep Brown, Granite, Medium Brown, Soft Brown), Clear Brow Gel with Capixyl, and LashExtend.

Approved appearance phrasings from the education catalogue: "supports the appearance of longer lashes," "supports the look of a fuller lash line," "firming peptide, supports the look of skin texture" (in C-Bright). The "46% saw fuller-looking brows in a study" hook must always stay perception-framed.

Red lines: never "blocks the hormone that causes follicles to shrink / stimulates the growth phase," never "stimulate follicular regeneration" or "increase new hair growth by 46%," never "79% density improvement" as a bare stat. If you cite a wear time for BrowSense, the only approved phrasing is "up to 16 hours."

Firming peptides in skincare: Matrixyl 3000 OS (Renewal Serum), ReneSeed (Evening Moisturizers), ChroNOline (SeneCell & Silk Primer).

Matrixyl® 3000 OS = Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7, in the Advanced Renewal Serum Retinol — approved "supports the appearance of collagen and elasticity."

ReneSeed = Nicotiana Benthamiana Hexapeptide-40 + Sh-Polypeptide-76, the overnight peptide in Evening Moisturizers — "the look of renewal."

ChroNOline™ = Caprooyl Tetrapeptide-3, in the MakeSense Silk Primer, SeneCell and GLP Complex — "reinforces the skin's structural matrix." Describe the look, not biology.

INCI detail. Matrixyl 3000 OS = Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7 (note: Tetrapeptide-7, not Tripeptide-7 — a legacy typo now corrected). The Advanced Renewal Serum Retinol also carries BIO-Placenta N = Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-9 and Sh-Polypeptide-11 ("five-growth-factor complex, supports the look of renewal").

ReneSeed = Nicotiana Benthamiana Hexapeptide-40 + Sh-Polypeptide-76, verified in Evening Moisturizer Dry, Normal-to-Dry and Normal-to-Oily. ChroNOline = Caprooyl Tetrapeptide-3, verified in MakeSense Silk Primer & Wrinkle Minimizer, SeneCell and GLP Complex. Approved catalogue phrasings: Matrixyl "supports the appearance of collagen and elasticity"; ReneSeed "overnight peptide for the look of renewal"; ChroNOline "reinforces the skin's structural matrix" / "supports the look of firmer skin architecture."

Red lines: never say ReneSeed "works in the retinoid pathway" or gives "retinoid-level results," and never say these peptides "stimulate collagen synthesis."

More of the roster: copper AccessPEP CTP, brightening X50PureWhite, oil-control TEGO PEP 4-17, and the lip peptide Maxi-Lip.

AccessPEP CTP = Bis(Tripeptide-1) Copper Acetate — copper peptide in the Daytime Moisturizers. X50PureWhite = Heptapeptide-15 Palmitate — brightening for tone evenness (also X50 Hyalufiller Powder in the Lip Line Corrector). C-Bright uses Acetyl Tetrapeptide-2 for dark-spot support.

TEGO PEP 4-17 = Tetrapeptide-17 (Oily-to-Acne moisturizers). SYN-STAR = Dipeptide Diaminobutyroyl Benzylamide Diacetate, for muscle-driven wrinkles. Maxi-Lip = Palmitoyl Tripeptide-1 (LipSmooth polish).

Verified INCI → product from the peptide list. AccessPEP CTP (1% solution) = Bis(Tripeptide-1) Copper Acetate — Daytime Moisturizer Dry, Normal-to-Dry, Normal-to-Oily; approved "copper peptide, supports the look of collagen." X50PureWhite = Heptapeptide-15 Palmitate — Daytime N-to-D / N-to-O and Evening Dry / N-to-D; approved "brightening peptide for tone evenness." Same INCI as X50 Hyalufiller Powder in the Lip Line Corrector (approved "support for the look of the lip border"). V-4s = Acetyl Tetrapeptide-2 — C-Bright Dark Spot Correcting Serum; approved "dark spot and brightening support."

TEGO PEP 4-17 = Tetrapeptide-17 — Evening Moisturizer Oily-to-Acne and the discontinued Daytime Oily-to-Acne (which also carried KOLLAREN = Tripeptide-1); approved "oil control, peptide strengthening for acne-prone skin." SYN-STAR = Dipeptide Diaminobutyroyl Benzylamide Diacetate — Rejuvenating Wrinkle Treatment; approved "softens muscle-driven wrinkles." Maxi-Lip = Palmitoyl Tripeptide-1 — LipSense LipSmooth Conditioning Polish; approved "peptide-driven plumping and conditioning."

Red lines: never call the Lip Line Corrector peptides "messenger drones" that "rebuild the dermal matrix," and never say SYN-STAR "relaxes mimetic muscles."

Peptides are not SenePlex+. SenePlex+ is the renewal complex; peptides are separate actives alongside it. Keep the two straight.

SenePlex+® is SeneGence's Orchid Stem Cell renewal complex — the subject of the SenePlex+ Clinical Findings packet. Peptides are a separate family that often share one formula (SeneCell and GLP Complex carry both ChroNOline and SenePlex+).

Don't fold peptides into SenePlex+'s numbers: up to 100% greater surface-cell turnover by day 18 belongs to SenePlex+ — no peptide has that study.

The SenePlex+ hero stat, stated exactly and always with its footnote: "up to 100% greater surface-cell turnover than untreated skin by day 18." That study was run on an Evening Moisturizer containing SenePlex+ — not on any isolated peptide — so it cannot be transferred to Capixyl, ChroNOline or any peptide in this packet.

Peptides carry their own supplier data, which is mostly perception/appearance-framed and was not part of the SenePlex+ studies; never blend the two. Products that carry both families: SeneCell (ChroNOline + SenePlex+) and GLP Complex. For the full sourced picture, point to the SenePlex+ Clinical Findings packet in this track.

Say what a peptide helps skin or hair LOOK like — never what it does to your biology. "Supports the appearance of…" is your safe frame.

The safe structure from the FTC/FDA report: [visual verb] + "appearance of" + [cosmetic noun]. Say "supports the appearance of fuller-looking hair" or "supports the look of firmer skin." Never say a peptide "stimulates collagen," "blocks DHT," "regenerates follicles," or "rebuilds the dermal matrix" — all flagged drug claims.

Any percentage needs study framing, perception-framed ("46% saw fuller-looking brows in a study"). These are cosmetics — describe appearance, not physiology.

Paired examples, straight from the language report (flagged → approved). Hair/lash: "Capixyl peptides support your follicles to grow fuller over time" → "Capixyl supports the look of a fuller lash line." "SenePeptide stimulates follicular regeneration / 46% increase in new lash growth" → "supports the appearance of keratin structure for fuller-looking lashes."

Lips: "X50 Hyalufiller peptides are messenger drones that tell fibroblasts to increase HA and elastin" and "Lip Line Corrector rebuilds the dermal matrix" → "supports the look of the lip border / helps reduce the appearance of lip lines." Wrinkle serum: "Dipeptide… relaxes mimetic muscles" → "softens the look of muscle-driven wrinkles." Skincare: "stimulate collagen production" → "supports the appearance of collagen and elasticity."

Rule recap: visual verb + "appearance of" + cosmetic noun; perception-frame every percentage next to its study; keep the disclosure; and never attach the SenePlex+ turnover stat to a peptide.