What order do I apply SeneGence skincare?

What changes between morning and evening?

The same preparation and treatment order leads to the moisturizer made for that time of day. Vitamin C works best in a more acidic environment and retinol in a less acidic one, so on nights you use Advanced SenePlex+® Renewal Serum with Retinol, SeneSerum-C® is a morning step only.

Step	Morning	Evening	Learn more
Cleanse	Cleanser for your skin type	Cleanser for your skin type	Directions and order
Prepare	Climate Control	Climate Control	What Climate Control does
Treat	GLP Complex™, then SeneCell™; SeneSerum-C® and other targeted treatments follow their own directions	GLP Complex™, then SeneCell™; Advanced SenePlex+® Renewal Serum with Retinol every other night at first, then nightly as tolerated, with no vitamin C after it	The Trio order
Eye care	NeoTight™ Eye Serum, then EyeCrème, before moisturizer	NeoTight™ Eye Serum, then EyeCrème, before moisturizer	The eye order
Lipid care when skin feels dry, tight or depleted	Nangai Oil after treatments and before moisturizer	Nangai Oil after treatments and before moisturizer	What Nangai Oil does
Moisturize	DayTime Moisturizer for your skin type	Evening Moisturizer for your skin type	Which moisturizer fits
Finish	Microbiome Defense Daytime Moisturizer SPF 15 as the last skincare step, by its label	Collagen Firming Night Pak as your final skincare step, every night or as desired	Where SPF goes · What the Night Pak does

Why does Climate Control go first?

After cleansing, pump a nickel-size amount of Climate Control onto the back of your hand and palette the gel essence over your face, neck, around the eyes and décolletage. Its gel essence mimics the skin’s Natural Moisturizing Factor, supports the barrier and helps optimize delivery and absorption of the beneficial ingredients that follow. Climate Control® brings balanced, lasting hydration, helps prevent moisture loss and soothes dry, sensitive skin. It helps support collagen and strengthen the skin barrier. Beauty Book 2026 (p. 14). Why Climate Control is your first step after cleansing.

What is the SeneGence morning order?

1. Cleanse with the 3 in 1 Cleanser for your skin type.
2. Exfoliate with Facial Resurfacer when skin needs it. Massage onto clean, moist skin. Rinse well. Use twice weekly or as needed. See why it uses Vanuatu volcanic ash.
3. Climate Control® deeply hydrates and prepares skin for treatment actives.
4. Treatment serums, lightest water-based texture first. Apply the Triple Cell Renewal Trio in this order: Climate Control, GLP Complex™ with SenePlex+® and Exosomes, then SeneCell™ SenePlex+® StemCell Concentrate. See the Trio order or Triple Cell Renewal Trio.
5. Eye care. NeoTight™ Eye Serum, then EyeCrème, both before moisturizer. See the eye order.
6. Nangai Oil, when skin feels dry, tight or depleted. Use three to five drops of Nangai Oil after treatments and before DayTime or Evening Moisturizer. Nangai Oil.
7. DayTime Moisturizer for your skin type.
8. Sun protection. Microbiome Defense Daytime Moisturizer SPF 15 gives broad-spectrum UVA/UVB protection with Zinc Oxide 6% and Octisalate 5%. See the sunscreen label. Apply Microbiome Defense Daytime Moisturizer SPF 15 generously and evenly as the last skincare step, 15 minutes before sun exposure, and reapply at least every 2 hours; use a water-resistant sunscreen if swimming or sweating. See where SPF goes in your routine.

What is the SeneGence evening order?

Remove long-wearing color before deep cleansing and skincare. Evening care places targeted treatments before Evening Moisturizer, with eye care, Collagen Firming Night Pak and overnight lip, brow or lash care as selected.

1. Remove long-wear color. For LipSense®, use Ooops!™ Lip Color Remover. Dip the wand, gently rub the applicator over the color, and wipe clean with tissue. For the easiest full removal, let Ooops!™ sit on your color for 60 seconds before you rub and wipe it away. For face and eyes, use Fooops!® Dual Phase Color Remover. Shake well to activate, spread a small amount from the palm over the face, let it sit about 20 seconds, then remove with a warm, wet washcloth. See how to remove long-wear makeup.
2. Cleanse, then palette on Climate Control and layer your treatments as in the morning.
3. Eye care, then Nangai Oil when skin feels dry.
4. Evening Moisturizer for your skin type.
5. Collagen Firming Night Pak, if you use it, as the final step. Every night or as desired, after completing the evening routine and evening moisturizer, dispense about a dime-size amount of Collagen Firming Night Pak onto the back of the hand and use clean fingertips or the contoured applicator brush (not included) to sweep a thin, even layer upward from décolletage through throat to face. See what Night Pak does.

Beauty Book 2026 (pp. 20, 23). The molecular-weight layering lesson shows why texture and product job matter more than memorizing a long list. See the remover directions, the Nangai Oil record or the Night Pak record.