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clinical finding

Caprooyl Tetrapeptide-3 — 28-day wrinkle-appearance study

product or technology studied

Ingredient study of Caprooyl Tetrapeptide-3

the finding

At day 28, a 2.5% Caprooyl Tetrapeptide-3 study serum improved the appearance of fine lines and wrinkles by 16% on average and by up to 29% in the randomized split-temple study.

Caprooyl Tetrapeptide-3 delivered clinically measured wrinkle-smoothing performance by day 28, while GLP Complex™ with SenePlex+® and Exosomes pairs Caprooyl Tetrapeptide-3 with Dextran for its peptide value.

For a customer: The day-28 result helps explain the Caprooyl Tetrapeptide-3 and Dextran peptide choice in GLP Complex™.

Complete measurements and study notes2 details
How it was evaluated
Randomized split-temple comparison; placebo serum versus the same serum containing 2.5% Caprooyl Tetrapeptide-3, applied twice daily; silicone replicas evaluated by interference-fringe profilometry at days 0, 28, and 56
Who took part
27 women ages 40–65 with healthy skin
Statistical context
The published article describes the day-28 fine-line and wrinkle reduction as significant but does not publish an exact p-value.
Information checked
2026-08-03

Measured results · 28 days

Average silicone-replica profilometry improvement in the appearance of fine lines and wrinkles

16% average improvement

At day 28, a 2.5% Caprooyl Tetrapeptide-3 study serum improved the appearance of fine lines and wrinkles by 16% on average in a randomized split-temple study.

What was measured
average silicone-replica profilometry improvement in the appearance of fine lines and wrinkles
When it was measured
28 days

Maximum silicone-replica profilometry improvement in the appearance of fine lines and wrinkles

up to 29% improvement

At day 28, a 2.5% Caprooyl Tetrapeptide-3 study serum improved the appearance of fine lines and wrinkles by up to 29% in a randomized split-temple study.

What was measured
maximum silicone-replica profilometry improvement in the appearance of fine lines and wrinkles
When it was measured
28 days