Do Peptides Work on Skin? What SeneGence Uses

Which peptide fits the result you want?

SeneGence uses peptides across skincare, lip care, brows, lashes, hair and makeup. Choose the peptide by the change you want to see, then read the ingredient maker’s full study behind it.

• For smoother-looking lines and firmer-looking skin, Caprooyl Tetrapeptide-3 with Dextran appears in GLP Complex™ with SenePlex+® and Exosomes, SeneCell™ SenePlex+® StemCell Concentrate, and MakeSense® Silk Primer & Pore Minimizer. A manufacturer reports 16% average improvement in fine-line and wrinkle appearance at day 28 in a randomized split-temple serum study of Glycerin, Water, Dextran, and Caprooyl Tetrapeptide-3. Read the complete study.
• For fuller-looking brows, lashes, and hair, Acetyl Tetrapeptide-3 with Trifolium Pratense (Clover) Flower Extract and Dextran appears in BrowSense® Volumizing Brow Gel, HairCovery® Strengthening & Thickening Hair Serum, LashSense® VolumeIntense® Mascara, LashSense® VolumeIntense® Waterproof Mascara, and UnderSense® 3-in-1 Maximizing Lash Primer. For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, the manufacturer reports up to 27% lash-density improvement with a 93% responder rate at week 8 in a 17-woman split-eye study of a 2.5% material gel versus opposite-eye placebo, used morning and evening. See the hair and lash evidence.
• For more even-looking tone, Palmitoyl sh-Octapeptide-24 Amide with Palmitoyl sh-Tripeptide-5 Norisoleucyl sh-Nonapeptide-1 appears in DayTime Moisturizer – Dry, DayTime Moisturizer – Normal to Dry, DayTime Moisturizer – Normal to Oily, Evening Moisturizer – Dry, Evening Moisturizer – Normal to Dry, and Evening Moisturizer – Normal to Oily. The ingredient manufacturer designed this two-peptide system, Palmitoyl sh-Octapeptide-24 Amide with Palmitoyl sh-Tripeptide-5 Norisoleucyl sh-Nonapeptide-1, for more even-looking tone and lighter-looking dark spots. It also reports a 56-day study of the pair. See the two-peptide role.
• For smoother, firmer, more radiant-looking night care, Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76 appears in Evening Moisturizer – Dry, Evening Moisturizer – Normal to Dry, and Evening Moisturizer – Normal to Oily. In a 20-woman, placebo-controlled split-face study of Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer used a preparation containing 2% material, applied twice daily. At day 28, it reported 16% lower wrinkle count, 11% lower wrinkle volume and 14% lower wrinkle depth across the full study group. Within the separate 85% responder group, wrinkle depth was 19.4% lower on average. Open the study.
• For multi-factor smoothing and visible renewal, sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-9, and sh-Polypeptide-11 appear together in Advanced SenePlex+® Renewal Serum with Retinol. Using PRIMOS Lite 3D to measure crow’s-feet after use of a cosmetic formula containing sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-9, and sh-Polypeptide-11, the manufacturer reports appearance improvement of 10% at two weeks and 21% at four weeks. See the five-factor findings.
• For softer-looking expression lines and less shine, Dipeptide Diaminobutyroyl Benzylamide Diacetate appears in NeoTight® Rejuvenating Anti-Wrinkle Serum. For Dipeptide Diaminobutyroyl Benzylamide Diacetate, the manufacturer reports statistically significant improvement in forehead wrinkles at day 28 and in mouth-frown lines, upper-lip vertical lines, and forehead gloss at day 7 in a 150-woman placebo-controlled facial study across three skin-tone groups using 4% material twice daily. Read the manufacturer evidence.
• For smoother-looking skin, Palmitoyl Tripeptide-1 with Palmitoyl Tetrapeptide-7 appears in Advanced SenePlex+® Renewal Serum with Retinol. On its current source page, the manufacturer pairs Palmitoyl Tripeptide-1 with Palmitoyl Tetrapeptide-7 for smoother-looking skin and visible repair. See the facial pair. For fuller-looking lips, Palmitoyl Tripeptide-1 appears separately in LipSense® Long-Lasting Lip Liner Pencil. For the full Ethylhexyl Palmitate, Tribehenin, Sorbitan Isostearate, and Palmitoyl Tripeptide-1 material, the manufacturer reports hydration 60% higher, superficial wrinkles 29% lower, and 40.7% higher average lip volume at day 29 in a 10-woman study, without a placebo group, of a colorless test lipstick containing 1% of the material, used three times daily. Read the lip-care study.
• For smoother-looking deep folds beside the mouth, Lip Line Corrector pairs Palmitoyl Tetrapeptide-50 with Heptapeptide-15 Palmitate. Lip Line Corrector visibly improves the appearance of vertical lip lines by up to 30% after six weeks of twice-daily use in an independent clinical study of 35 women ages 40–70, measured by expert grading against baseline. Beauty Book 2026 (p. 18). For the exact two-peptide material containing Palmitoyl Tetrapeptide-50 and Heptapeptide-15 Palmitate, the manufacturer reports up to 70% lower image-analyzed appearance of deep folds beside the mouth, visible by day 14, in a 28-day study of five adults using 1% material. See the deep-fold evidence.
• For denser, fuller-looking lashes, Myristoyl Pentapeptide-17 appears in LashExtend. For Myristoyl Pentapeptide-17, the manufacturer reports lash density rising through day 42 (33.67% at day 14, 46.71% at day 28 and 60.60% at day 42) in a four-person study, without a placebo group, of eyeliner serums made with 5% or 10% of the peptide material, applied once nightly. See the lash study.
• For longer-, fuller-, stronger-looking lash support, Biotinoyl Tripeptide-1 appears in UnderSense® 3-in-1 Maximizing Lash Primer; the manufacturer material combines it with Panthenol. For longer-, fuller-, stronger-looking lashes, the peptide’s manufacturer builds Biotinoyl Tripeptide-1 into a full ingredient combination with Glycerin, Water and Panthenol, according to its current summary. See the lash-support role. Apply UnderSense, let it dry fully, then finish with one VolumeIntense Mascara or VolumeIntense Waterproof Mascara.
• Oligopeptide-10 also appears in UnderSense® 3-in-1 Maximizing Lash Primer, with skin-clarity research of its own. For Oligopeptide-10, a manufacturer reports C. acnes activity and improved appearance of blemishes and red blotchy spots in an ingredient-research summary based on data on file. See the separate ingredient research.
• For firming and line care with daytime moisture, Bis(Tripeptide-1) Copper Acetate appears in DayTime Moisturizer – Dry, DayTime Moisturizer – Normal to Dry, and DayTime Moisturizer – Normal to Oily. The ingredient manufacturer makes Bis(Tripeptide-1) Copper Acetate for firmer-looking skin and wrinkle care and points to several controlled facial studies. See the copper-peptide source.
• For a soft-focus makeup step, Acetyl Hexapeptide-8 appears in Translucent Loose Powder. For Acetyl Hexapeptide-8, a manufacturer reports 20.6% lower wrinkle volume and 15.9% lower wrinkle length at day 7 in a randomized split-face placebo study of 22 women using a leave-on test cream containing 2% of the peptide solution twice daily. Read the ingredient studies.

How do I build a peptide routine?

Start with cleansing, then follow each chosen product’s directions and add only the treatment steps your skin calls for before moisturizer and eye care. In the morning choose DayTime Moisturizer – Dry, Normal to Dry or Normal to Oily; in the evening choose Read the official ingredients and directions, Normal to Dry or Normal to Oily. Explore SeneGence’s peptide guide to compare every peptide ingredient and its original sources.