Science & Ingredients
What Peptides Are in SeneGence Products? Exact INCI Guide
SeneGence formulas use exact peptides for distinct cosmetic jobs: Caprooyl Tetrapeptide-3 and Palmitoyl Tripeptide-1 for smoother-looking skin, Acetyl Tetrapeptide-3 for fuller-looking brows and lashes, Myristoyl Pentapeptide-17 for the lash line, and copper and Nicotiana peptides in facial care. See the exact current formula beside each INCI before choosing a product.
- Peptides
Caprooyl Tetrapeptide-3 with Dextran
For smoother-looking lines and firmer-looking skin, look for Caprooyl Tetrapeptide-3 with Dextran in GLP Complex™ with SenePlex+® and Exosomes, SeneCell™ SenePlex+® StemCell Concentrate, and MakeSense® Silk Primer & Pore Minimizer.
how to use it
Choose by routine job: GLP Complex for targeted care of deep wrinkles and the look of facial volume, SeneCell for concentrated hydration, or Silk Primer for a smoother-looking base before complexion makeup.
the science
Human serum studies used the full Glycerin, Water, Dextran, and Caprooyl Tetrapeptide-3 material; separate cell and explant studies tested Caprooyl Tetrapeptide-3.
The ingredient’s maker reports 16% average improvement in fine-line and wrinkle appearance at day 28 in a randomized split-temple serum study of Glycerin, Water, Dextran, and Caprooyl Tetrapeptide-3.
The evidence page also covers longer-term ultrasound, consumer, cell, and skin-explant findings. Read the complete Caprooyl Tetrapeptide-3 evidence.
Acetyl Tetrapeptide-3 with Clover and Dextran
For fuller-looking brows, lashes, and hair, look for Acetyl Tetrapeptide-3 with Trifolium Pratense (Clover) Flower Extract and Dextran in BrowSense® Volumizing Brow Gel, HairCovery® Strengthening & Thickening Hair Serum, LashSense® VolumeIntense® Mascara, LashSense® VolumeIntense® Waterproof Mascara, and UnderSense® 3-in-1 Maximizing Lash Primer.
how to use it
Match the format to the beauty goal: BrowSense shapes and holds, HairCovery is the leave-on scalp-serum step, UnderSense primes and builds lashes, and one regular or waterproof VolumeIntense mascara supplies the color finish.
the science
The ingredient’s maker reports fuller-looking lash and hair findings across distinct human studies, with supportive follicle and scalp-microbiome work.
For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, the ingredient’s maker reports up to 27% lash-density improvement with a 93% responder rate at week 8 in a 17-woman split-eye study of a 2.5% material gel versus opposite-eye placebo, used morning and evening.
The Two-Peptide Tone Pair
For more even-looking tone and lighter-looking dark spots, look for Palmitoyl sh-Octapeptide-24 Amide with Palmitoyl sh-Tripeptide-5 Norisoleucyl sh-Nonapeptide-1.
how to use it
You will find the pair in DayTime Moisturizer - Dry, DayTime Moisturizer - Normal to Dry, DayTime Moisturizer - Normal to Oily, Evening Moisturizer - Dry, Evening Moisturizer - Normal to Dry, and Evening Moisturizer - Normal to Oily. Choose among these six US formulas by your skin type, the texture you enjoy and the time of day.
the science
The ingredient manufacturer designed this two-peptide system, Palmitoyl sh-Octapeptide-24 Amide with Palmitoyl sh-Tripeptide-5 Norisoleucyl sh-Nonapeptide-1, for more even-looking tone and lighter-looking dark spots. It also reports a 56-day study of the pair.
Plant-Produced Peptide Night Care
For smoother, firmer, more radiant-looking night care, look for Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76 in the current US formulas of Evening Moisturizer - Dry, Evening Moisturizer - Normal to Dry and Evening Moisturizer - Normal to Oily.
how to use it
This fusion peptide begins in plants: the ingredient manufacturer produces it through Nicotiana benthamiana biotechnology and vertical farming. You will find it in three US night creams—Evening Moisturizer - Dry, Evening Moisturizer - Normal to Dry and Evening Moisturizer - Normal to Oily—so choose the texture for your skin type.
the science
In a 20-woman, placebo-controlled split-face study of Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer used a preparation containing 2% material, applied twice daily. At day 28, it reported 16% lower wrinkle count, 11% lower wrinkle volume and 14% lower wrinkle depth across the full study group. Within the separate 85% responder group, wrinkle depth was 19.4% lower on average.
The research also examines firmness, elasticity, radiance, hydration, pores, roughness, skin thickness, barrier-associated genes, collagen and skin explants. Read the fusion-peptide evidence.
Five Recombinant Factors in Advanced Renewal

For multi-factor smoothing and visible renewal, Advanced SenePlex+® Renewal Serum with Retinol combines sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-9, and sh-Polypeptide-11.
how to use it
Choose this evening facial treatment when you want retinol, the five-factor complex, and a separate Palmitoyl peptide pair in one visible-renewal formula.
the science
Using PRIMOS Lite 3D to measure crow’s-feet after use of a cosmetic formula containing sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-9, and sh-Polypeptide-11, the ingredient’s maker reports appearance improvement of 10% at two weeks and 21% at four weeks.
For the material containing sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-9, and sh-Polypeptide-11, the ingredient’s maker reports a below-eye wrinkle image-analysis measure improved 38% at two weeks and 46% at four weeks.
Expression-Line Peptide in NeoTight Rejuvenating

For softer-looking expression lines and smoother, less shiny-looking skin, NeoTight® Rejuvenating Anti-Wrinkle Serum contains Dipeptide Diaminobutyroyl Benzylamide Diacetate.
the science
For Dipeptide Diaminobutyroyl Benzylamide Diacetate, the ingredient’s maker reports statistically significant improvement in forehead wrinkles at day 28 and in mouth-frown lines, upper-lip vertical lines, and forehead gloss at day 7 in a 150-woman placebo-controlled facial study across three skin-tone groups using 4% material twice daily.
The evidence page also covers user-reported smoothness and shine plus the manufacturer’s cell and biochemical work. Read the dipeptide evidence.
Palmitoyl Tripeptide-1 in Skin and Lip Care
For smoother-looking renewal, Advanced SenePlex+® Renewal Serum with Retinol pairs Palmitoyl Tripeptide-1 with Palmitoyl Tetrapeptide-7.
For hydrated, smoother, fuller-looking lips, LipSense® Long-Lasting Lip Liner Pencil carries Palmitoyl Tripeptide-1 in a separate lip-care context.
how to use it
Choose by zone and finish: Advanced Renewal is a facial treatment serum, while Lip Liner gives precise definition with conditioning lip care.
the science
The maker of this peptide pair combines Palmitoyl Tripeptide-1 with Palmitoyl Tetrapeptide-7 for smoother-looking skin and visible repair; each peptide carries palmitic acid, the palmitoyl in its name.
For the full Ethylhexyl Palmitate, Tribehenin, Sorbitan Isostearate, and Palmitoyl Tripeptide-1 material, the ingredient’s maker reports hydration 60% higher, superficial wrinkles 29% lower, and 40.7% higher average lip volume at day 29 in an uncontrolled 10-woman study of a colorless lipstick containing 1% material, used three times daily.
For the full Ethylhexyl Palmitate, Tribehenin, Sorbitan Isostearate, and Palmitoyl Tripeptide-1 material, the ingredient’s maker reports that the 10 participants noticed improved lip condition and smoothness with less flaking at day 29 after using the 1% material colorless lipstick three times daily.
The Lip Line Corrector Peptide Pair

For smoother-looking deep lip-area folds and plumper-looking contours, Lip Line Corrector pairs Palmitoyl Tetrapeptide-50 with Heptapeptide-15 Palmitate.
how to use it
Use it as the targeted lip-area step when the look of vertical lines and deeper folds beside the mouth leads your choice.
the science
For the exact two-peptide material containing Palmitoyl Tetrapeptide-50 and Heptapeptide-15 Palmitate, the ingredient’s maker reports up to 70% lower image-analyzed appearance of deep folds beside the mouth, visible by day 14, in a 28-day study of five adults using 1% material.
Myristoyl Pentapeptide-17 in LashExtend

For denser, fuller-looking lashes, LashExtend contains Myristoyl Pentapeptide-17.
how to use it
Choose LashExtend as the dedicated lash-serum format, applied at the lash base morning and evening as directed until the desired result.
the science
For Myristoyl Pentapeptide-17, the ingredient’s maker reports induction of hair-specific keratin genes after 48 hours in an in vitro human keratinocyte assay using 0.001% neat material.
For Myristoyl Pentapeptide-17, the ingredient maker’s conclusion slide reports increasing lash density through day 42, with values of 33.67% at day 14, 46.71% at day 28, and 60.60% at day 42 in a four-person uncontrolled lash-root study testing 5% and 10% supplier-material eyeliner serums once nightly; allocation between strengths and whether or how the conclusion series combines them are not disclosed.
For Myristoyl Pentapeptide-17, the ingredient’s maker labels a single right-eyelash image series for its 10% supplier-material eyeliner-serum example with increases of 46.26% at day 14, 66.3% at day 28, and 72.29% at day 42.
Biotinoyl Tripeptide-1 with Panthenol in UnderSense

For longer-, fuller-, stronger-looking lash support, UnderSense® 3-in-1 Maximizing Lash Primer contains Biotinoyl Tripeptide-1.
how to use it
Apply UnderSense to top and bottom lashes, add coats for more buildable length and volume, and let it fully dry before finishing with one VolumeIntense mascara.
the science
The manufacturer material combines Glycerin, Water, Panthenol, and Biotinoyl Tripeptide-1.
For longer-, fuller-, stronger-looking lashes, the ingredient’s maker builds Biotinoyl Tripeptide-1 into a full ingredient combination with Glycerin, Water and Panthenol, according to its current summary.
Oligopeptide-10 and Skin-Clarity Research
UnderSense® 3-in-1 Maximizing Lash Primer also carries Oligopeptide-10, and its ingredient maker reports cosmetic skin-clarity research for this exact peptide.
how to use it
In your routine, UnderSense supplies a light-beige preparation layer, buildable volume and length, and a base for mascara. Let it fully dry before the color finish.
the science
For Oligopeptide-10, the ingredient’s maker reports C. acnes activity and improved appearance of blemishes and red blotchy spots in an ingredient-research summary based on data on file.
Copper Peptide in DayTime Moisturizers
For firming and line care in daytime moisture, look for Bis(Tripeptide-1) Copper Acetate in DayTime Moisturizer - Dry, DayTime Moisturizer - Normal to Dry, and DayTime Moisturizer - Normal to Oily.
how to use it
Choose one DayTime texture for your skin: richer comfort for Dry, balanced hydration for Normal to Dry, or hydration with a more matte T-zone for Normal to Oily.
the science
The ingredient manufacturer makes Bis(Tripeptide-1) Copper Acetate for firmer-looking skin and wrinkle care and points to several controlled facial studies.
Acetyl Hexapeptide-8 in Translucent Loose Powder

Translucent Loose Powder creates a soft-focus setting finish. Its formula also includes Acetyl Hexapeptide-8.
how to use it
Pick up the loose powder with a brush and apply where you want a soft-focus finish.
the science
The manufacturer studies used leave-on cream test articles, while Translucent Loose Powder is the current SeneGence formula where this exact INCI appears.
For Acetyl Hexapeptide-8, the ingredient’s maker reports 20.6% lower wrinkle volume and 15.9% lower wrinkle length at day 7 in a randomized split-face placebo study of 22 women using a leave-on cream with 2% supplier solution twice daily.
For Acetyl Hexapeptide-8, the ingredient’s maker reports wrinkle roughness 20.4% lower at day 28 in an uncontrolled instrumental study of 18 women using a leave-on cream with 5% supplier solution twice daily.
For Acetyl Hexapeptide-8, the ingredient’s maker reports up to 32% lower glutamate release at 2 mM in an in vitro assay.
Choose a Peptide Routine by Goal
Start with the change you want to see, then find the formula that carries the matching peptide.
- Lines and firmness
- GLP Complex™ with SenePlex+® and Exosomes, SeneCell™ SenePlex+® StemCell Concentrate and MakeSense® Silk Primer & Pore Minimizer carry Caprooyl Tetrapeptide-3; NeoTight® Rejuvenating Anti-Wrinkle Serum targets expression lines with Dipeptide Diaminobutyroyl Benzylamide Diacetate; each DayTime Moisturizer adds copper-peptide firming care.
- Even tone
- The six DayTime and Evening Moisturizers carry the two-peptide tone pair.
- Night care
- Evening Moisturizer - Dry, Normal to Dry or Normal to Oily brings the plant-produced fusion peptide; Advanced SenePlex+® Renewal Serum with Retinol adds multi-factor renewal.
- Lips
- LipSense® Long-Lasting Lip Liner Pencil carries Palmitoyl Tripeptide-1 for hydrated, smoother, fuller-looking lips.
- Lip-line folds
- Lip Line Corrector pairs Palmitoyl Tetrapeptide-50 with Heptapeptide-15 Palmitate.
- Brows and hair
- BrowSense® Volumizing Brow Gel and HairCovery® Strengthening & Thickening Hair Serum carry Acetyl Tetrapeptide-3 with clover.
- Lashes
- LashExtend carries Myristoyl Pentapeptide-17 for denser, fuller-looking lashes. UnderSense® 3-in-1 Maximizing Lash Primer brings Biotinoyl Tripeptide-1 and Acetyl Tetrapeptide-3 with clover; once it dries, finish with LashSense® VolumeIntense® Mascara for humidity- and smudge-resistant color or LashSense® VolumeIntense® Waterproof Mascara when sweat, tears or water resistance matters.
how to use it
Choose one product for each goal and follow its own directions. See the complete skincare order for where each facial step goes.
the science
Study results at a glance
Caprooyl Tetrapeptide-3 with Dextran — wrinkle and skin-support studies8 results
| Result | Kind of result | When it was measured |
|---|---|---|
| In an in vitro fibroblast assay of Caprooyl Tetrapeptide-3, the ingredient’s maker reports laminin 26% higher and fibronectin 60% higher after 48 hours. | Ingredient study | 48 hours |
| In a corticoid-stressed four-donor human-skin explant model of Caprooyl Tetrapeptide-3, the ingredient’s maker reports collagen VII staining 34% higher and laminin-5 staining 49% higher versus corticoid alone at day 3. | Ingredient study | day 3 |
| In the corticoid-stressed four-donor human-skin explant model, the ingredient’s maker reports that Caprooyl Tetrapeptide-3 helped prevent the dermal-epidermal-junction flattening seen with corticoid alone at day 3. | Ingredient study | day 3 |
| The ingredient’s maker reports 16% average improvement in fine-line and wrinkle appearance at day 28 in a randomized split-temple serum study of Glycerin, Water, Dextran, and Caprooyl Tetrapeptide-3. | Ingredient study | day 28 |
| In the same randomized split-temple serum study, the ingredient’s maker reports that the full Glycerin, Water, Dextran, and Caprooyl Tetrapeptide-3 material improved fine-line and wrinkle appearance by up to 29% at day 28. | Ingredient study | day 28 |
Show 3 more results
| Result | Kind of result | When it was measured |
|---|---|---|
| In the age-defined 50–65 subgroup of the same 27-woman randomized split-temple serum study of the full Glycerin, Water, Dextran, and Caprooyl Tetrapeptide-3 material, the ingredient’s maker reports 27% average and up to 35% improvement in fine-line and wrinkle appearance at day 56. | Ingredient study | day 56 |
| In a separate 30-woman self-assessment of a serum with 2.5% of the full Glycerin, Water, Dextran, and Caprooyl Tetrapeptide-3 material used twice daily, the ingredient’s maker reports favorable perceptions of smoothness, firmness, evenness, and a rested look at day 56, plus favorable eye-area tolerability. | Participant feedback | day 56 |
| In a 27-woman split-temple ultrasound study of a serum with 2.5% of the full Glycerin, Water, Dextran, and Caprooyl Tetrapeptide-3 material used twice daily, the ingredient’s maker reports improvement versus placebo in 78% of participants on the upper-dermis entropy measure at day 168. | Ingredient study | day 168 |
See the full finding: Caprooyl Tetrapeptide-3 with Dextran — wrinkle and skin-support studies
Acetyl Tetrapeptide-3 with Clover and Dextran — hair and lash studies8 results
| Result | Kind of result | When it was measured |
|---|---|---|
| For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, the ingredient’s maker reports follicle elongation 58%, 51%, and 87% higher than untreated follicles at days 4, 7, and 11 in an ex vivo assay of 22 treated and 34 untreated follicles from one donor using 1% material. | Measured result | day 4; day 7; day 11 |
| For exact Acetyl Tetrapeptide-3, the ingredient’s maker reports 47% greater elongation than untreated follicles at day 7 in an ex vivo assay of 15 peptide-treated, 27 minoxidil-reference, and 27 untreated follicles; its stated reference comparison belongs only to that assay. | Measured result | day 7 |
| For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, the ingredient’s maker reports mean anagen density 9% higher, mean telogen density 42% lower, and anagen-to-telogen ratio 88% higher at day 90 in a 23-person baseline-controlled rinse-off scalp study using 1.5% material in shampoo and conditioner every two days. | Measured result | day 90 |
| For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, the ingredient’s maker reports the two specified Cutibacterium acnes scalp-microbiome ratios 36% and 62% lower at day 90 in 21 people using the rinse-off regimen. | Measured result | day 90 |
| For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, the ingredient’s maker reports a 15% favorable anagen-density delta, 52% favorable telogen-density delta, and 79-point between-group anagen-to-telogen-ratio delta after four months in a randomized 29-person leave-on scalp study using 5% material nightly. | Measured result | four months |
Show 3 more results
| Result | Kind of result | When it was measured |
|---|---|---|
| For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, the ingredient’s maker reports up to 27% lash-density improvement with a 93% responder rate at week 8 in a 17-woman split-eye study of a 2.5% material gel versus opposite-eye placebo, used morning and evening. | Measured result | week 8 |
| For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, the ingredient’s maker reports 45.5% more new lashes on the active side at week 8 while the placebo side recorded no new lashes in the same 17-woman split-eye study. | Measured result | week 8 |
| For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, the ingredient’s maker reports lash length increased by up to 0.70 mm at week 4 in the same 17-woman split-eye study and puts the active-side improvement at three times placebo at week 4 and five times placebo at week 8. | Measured result | week 4; week 8 |
See the full finding: Acetyl Tetrapeptide-3 with Clover and Dextran — hair and lash studies · Open the source document (PDF)
Nicotiana fusion peptide — 28-day skin-appearance study10 results
| Result | Kind of result | When it was measured |
|---|---|---|
| For Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer reports increased expression of selected genes associated with epidermal lipids and barrier function after 24 and 48 hours in primary human keratinocytes exposed to 20 ng/mL active, stated as 2% material. | Ingredient study | 24 hours; 48 hours |
| For Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer reports dose-responsive collagen I after 48 hours in adult human dermal fibroblasts and describes its assay-specific potency as four times the retinol reference. | Ingredient study | 48 hours |
| For Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer reports qualitative increases in epidermal thickness and lipid staining at day 8 in an exploratory human-skin explant from one 52-year-old donor treated with a cream containing 1.5% material. | Ingredient study | day 8 |
| In a 20-woman, placebo-controlled split-face study of Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer used a preparation containing 2% material, applied twice daily. At day 28, it reported 16% lower wrinkle count, 11% lower wrinkle volume and 14% lower wrinkle depth across the full study group. Within the separate 85% responder group, wrinkle depth was 19.4% lower on average. | Measured result | day 28 |
| For Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer reports whole-cohort firmness 11% higher and elasticity 6% higher at day 28 in the 20-woman placebo-controlled split-face study using 2% material twice daily; the 95% responder subsets averaged 12.6% and 6.1% higher. | Measured result | day 28 |
Show 5 more results
| Result | Kind of result | When it was measured |
|---|---|---|
| For Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer reports whole-cohort pore diameter 11.6% lower at day 28 in the 20-woman placebo-controlled split-face study; the 80% responder subset averaged 16.2% lower, with improvement up to 44%. | Measured result | day 28 |
| For Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer reports whole-cohort radiance 12.5% higher at day 28 in the 20-woman placebo-controlled split-face study; the 90% responder subset averaged 14.4% higher, with improvement up to 42%. | Measured result | day 28 |
| For Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer reports whole-cohort hydration 12.4% higher and transepidermal water loss 9.5% lower at day 28 in the 20-woman placebo-controlled split-face study; hydration had 100% responders, while the 90% water-loss responder subset averaged 11.2% lower. | Measured result | day 28 |
| For Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer reports whole-cohort skin roughness 6.9% lower at day 28 in the 20-woman placebo-controlled split-face study; the 75% responder subset averaged 12.6% lower, with improvement up to 26%. | Measured result | day 28 |
| For Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer reports skin thickness 8.0% higher among the 85% responder subset at day 28 in the 20-woman placebo-controlled split-face ultrasound study, with improvement up to 16%. | Measured result | day 28 |
See the full finding: Nicotiana fusion peptide — 28-day skin-appearance study · Open the source document (PDF)
Five sh-Oligopeptide and sh-Polypeptide factors in Advanced SenePlex+ Renewal Serum2 results
| Result | Kind of result | When it was measured |
|---|---|---|
| Using PRIMOS Lite 3D to measure crow’s-feet after use of a cosmetic formula containing sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-9, and sh-Polypeptide-11, the ingredient’s maker reports appearance improvement of 10% at two weeks and 21% at four weeks. | Measured result | two weeks; four weeks |
| For the material containing sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-9, and sh-Polypeptide-11, the ingredient’s maker reports a below-eye wrinkle image-analysis measure improved 38% at two weeks and 46% at four weeks. | Measured result | two weeks; four weeks |
See the full finding: Five sh-Oligopeptide and sh-Polypeptide factors in Advanced SenePlex+ Renewal Serum · Open the source document (PDF)
Dipeptide Diaminobutyroyl Benzylamide Diacetate — expression-line study4 results
| Result | Kind of result | When it was measured |
|---|---|---|
| For Dipeptide Diaminobutyroyl Benzylamide Diacetate, the ingredient’s maker reports up to 3.5-fold PLOD3 gene-expression induction after 24 hours in fibroblasts from a 63-year-old donor exposed to the exact peptide; this is an in vitro mechanism endpoint. | Measured result | 24 hours |
| For Dipeptide Diaminobutyroyl Benzylamide Diacetate, the ingredient’s maker reports statistically significant improvement in forehead wrinkles at day 28 and in mouth-frown lines, upper-lip vertical lines, and forehead gloss at day 7 in a 150-woman placebo-controlled facial study across three skin-tone groups using 4% material twice daily. | Ingredient study | day 7 for mouth-frown lines, upper-lip vertical lines, and forehead gloss; day 28 for forehead wrinkles |
| For Dipeptide Diaminobutyroyl Benzylamide Diacetate, the ingredient’s maker reports day-28 active-cohort agreement for smoother, less shiny, and more beautiful-looking skin across the three skin-tone groups, plus 83% average confidence agreement among 75 users. | Participant feedback | day 28 |
| For Dipeptide Diaminobutyroyl Benzylamide Diacetate, the ingredient’s maker reports dose-dependent DPP4 inhibition from 0.8 to 100 ppm in a cell-free biochemical assay. | Measured result | assay time not disclosed |
See the full finding: Dipeptide Diaminobutyroyl Benzylamide Diacetate — expression-line study · Open the source document (PDF)
Palmitoyl Tripeptide-1 — 29-day lip-care study2 results
| Result | Kind of result | When it was measured |
|---|---|---|
| For the full Ethylhexyl Palmitate, Tribehenin, Sorbitan Isostearate, and Palmitoyl Tripeptide-1 material, the ingredient’s maker reports hydration 60% higher, superficial wrinkles 29% lower, and 40.7% higher average lip volume at day 29 in an uncontrolled 10-woman study of a colorless lipstick containing 1% material, used three times daily. | Measured result | day 29 |
| For the full Ethylhexyl Palmitate, Tribehenin, Sorbitan Isostearate, and Palmitoyl Tripeptide-1 material, the ingredient’s maker reports that the 10 participants noticed improved lip condition and smoothness with less flaking at day 29 after using the 1% material colorless lipstick three times daily. | Ingredient study | day 29 |
See the full finding: Palmitoyl Tripeptide-1 — 29-day lip-care study
Lip Line Corrector Peptide Pair: What the Palmitoyl Tetrapeptide-50 and Heptapeptide-15 Palmitate Deep-Fold Study Found1 result
| Result | Kind of result | When it was measured |
|---|---|---|
| For the exact two-peptide material containing Palmitoyl Tetrapeptide-50 and Heptapeptide-15 Palmitate, the ingredient’s maker reports up to 70% lower image-analyzed appearance of deep folds beside the mouth, visible by day 14, in a 28-day study of five adults using 1% material. | Measured result | day 14; day 28 |
See the full finding: Lip Line Corrector Peptide Pair: What the Palmitoyl Tetrapeptide-50 and Heptapeptide-15 Palmitate Deep-Fold Study Found · Open the source document (PDF)
Myristoyl Pentapeptide-17 — lash-density and keratin-gene studies3 results
| Result | Kind of result | When it was measured |
|---|---|---|
| For Myristoyl Pentapeptide-17, the ingredient’s maker reports induction of hair-specific keratin genes after 48 hours in an in vitro human keratinocyte assay using 0.001% neat material. | Ingredient study | 48 hours |
| For Myristoyl Pentapeptide-17, the ingredient maker’s conclusion slide reports increasing lash density through day 42, with values of 33.67% at day 14, 46.71% at day 28, and 60.60% at day 42 in a four-person uncontrolled lash-root study testing 5% and 10% supplier-material eyeliner serums once nightly; allocation between strengths and whether or how the conclusion series combines them are not disclosed. | Measured result | day 14; day 28; day 42 |
| For Myristoyl Pentapeptide-17, the ingredient’s maker labels a single right-eyelash image series for its 10% supplier-material eyeliner-serum example with increases of 46.26% at day 14, 66.3% at day 28, and 72.29% at day 42. | Measured result | day 14; day 28; day 42 |
See the full finding: Myristoyl Pentapeptide-17 — lash-density and keratin-gene studies · Open the source document (PDF)
Acetyl Hexapeptide-8 — split-face wrinkle studies3 results
| Result | Kind of result | When it was measured |
|---|---|---|
| For Acetyl Hexapeptide-8, the ingredient’s maker reports 20.6% lower wrinkle volume and 15.9% lower wrinkle length at day 7 in a randomized split-face placebo study of 22 women using a leave-on cream with 2% supplier solution twice daily. | Measured result | day 7 |
| For Acetyl Hexapeptide-8, the ingredient’s maker reports wrinkle roughness 20.4% lower at day 28 in an uncontrolled instrumental study of 18 women using a leave-on cream with 5% supplier solution twice daily. | Measured result | day 28 |
| For Acetyl Hexapeptide-8, the ingredient’s maker reports up to 32% lower glutamate release at 2 mM in an in vitro assay. | Measured result | assay duration not disclosed |
See the full finding: Acetyl Hexapeptide-8 — split-face wrinkle studies · Open the source document (PDF)