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Science & Ingredients

What Peptides Are in SeneGence Products? Exact INCI Guide

SeneGence formulas use exact peptides for distinct cosmetic jobs: Caprooyl Tetrapeptide-3 and Palmitoyl Tripeptide-1 for smoother-looking skin, Acetyl Tetrapeptide-3 for fuller-looking brows and lashes, Myristoyl Pentapeptide-17 for the lash line, and copper and Nicotiana peptides in facial care. See the exact current formula beside each INCI before choosing a product.

  • Peptides

Caprooyl Tetrapeptide-3 with Dextran

For smoother-looking lines and firmer-looking skin, look for Caprooyl Tetrapeptide-3 with Dextran in GLP Complex™ with SenePlex+® and Exosomes, SeneCell™ SenePlex+® StemCell Concentrate, and MakeSense® Silk Primer & Pore Minimizer.

how to use it

Choose by routine job: GLP Complex for targeted care of deep wrinkles and the look of facial volume, SeneCell for concentrated hydration, or Silk Primer for a smoother-looking base before complexion makeup.

the science

Human serum studies used the full Glycerin, Water, Dextran, and Caprooyl Tetrapeptide-3 material; separate cell and explant studies tested Caprooyl Tetrapeptide-3.

The ingredient’s maker reports 16% average improvement in fine-line and wrinkle appearance at day 28 in a randomized split-temple serum study of Glycerin, Water, Dextran, and Caprooyl Tetrapeptide-3.

The evidence page also covers longer-term ultrasound, consumer, cell, and skin-explant findings. Read the complete Caprooyl Tetrapeptide-3 evidence.

Acetyl Tetrapeptide-3 with Clover and Dextran

For fuller-looking brows, lashes, and hair, look for Acetyl Tetrapeptide-3 with Trifolium Pratense (Clover) Flower Extract and Dextran in BrowSense® Volumizing Brow Gel, HairCovery® Strengthening & Thickening Hair Serum, LashSense® VolumeIntense® Mascara, LashSense® VolumeIntense® Waterproof Mascara, and UnderSense® 3-in-1 Maximizing Lash Primer.

how to use it

Match the format to the beauty goal: BrowSense shapes and holds, HairCovery is the leave-on scalp-serum step, UnderSense primes and builds lashes, and one regular or waterproof VolumeIntense mascara supplies the color finish.

the science

The ingredient’s maker reports fuller-looking lash and hair findings across distinct human studies, with supportive follicle and scalp-microbiome work.

For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, the ingredient’s maker reports up to 27% lash-density improvement with a 93% responder rate at week 8 in a 17-woman split-eye study of a 2.5% material gel versus opposite-eye placebo, used morning and evening.

Open the complete hair, lash, follicle, and scalp evidence.

The Two-Peptide Tone Pair

For more even-looking tone and lighter-looking dark spots, look for Palmitoyl sh-Octapeptide-24 Amide with Palmitoyl sh-Tripeptide-5 Norisoleucyl sh-Nonapeptide-1.

how to use it

You will find the pair in DayTime Moisturizer - Dry, DayTime Moisturizer - Normal to Dry, DayTime Moisturizer - Normal to Oily, Evening Moisturizer - Dry, Evening Moisturizer - Normal to Dry, and Evening Moisturizer - Normal to Oily. Choose among these six US formulas by your skin type, the texture you enjoy and the time of day.

the science

The ingredient manufacturer designed this two-peptide system, Palmitoyl sh-Octapeptide-24 Amide with Palmitoyl sh-Tripeptide-5 Norisoleucyl sh-Nonapeptide-1, for more even-looking tone and lighter-looking dark spots. It also reports a 56-day study of the pair.

See the two-peptide tone role.

Plant-Produced Peptide Night Care

For smoother, firmer, more radiant-looking night care, look for Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76 in the current US formulas of Evening Moisturizer - Dry, Evening Moisturizer - Normal to Dry and Evening Moisturizer - Normal to Oily.

how to use it

This fusion peptide begins in plants: the ingredient manufacturer produces it through Nicotiana benthamiana biotechnology and vertical farming. You will find it in three US night creams—Evening Moisturizer - Dry, Evening Moisturizer - Normal to Dry and Evening Moisturizer - Normal to Oily—so choose the texture for your skin type.

the science

In a 20-woman, placebo-controlled split-face study of Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer used a preparation containing 2% material, applied twice daily. At day 28, it reported 16% lower wrinkle count, 11% lower wrinkle volume and 14% lower wrinkle depth across the full study group. Within the separate 85% responder group, wrinkle depth was 19.4% lower on average.

The research also examines firmness, elasticity, radiance, hydration, pores, roughness, skin thickness, barrier-associated genes, collagen and skin explants. Read the fusion-peptide evidence.

Five Recombinant Factors in Advanced Renewal

A blue bottle with a blue cap, gold band and gold base, Advanced SenePlex+® Renewal Serum with Retinol.
Advanced SenePlex+® Renewal Serum with Retinol — the product example for this ingredient.

For multi-factor smoothing and visible renewal, Advanced SenePlex+® Renewal Serum with Retinol combines sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-9, and sh-Polypeptide-11.

how to use it

Choose this evening facial treatment when you want retinol, the five-factor complex, and a separate Palmitoyl peptide pair in one visible-renewal formula.

the science

Using PRIMOS Lite 3D to measure crow’s-feet after use of a cosmetic formula containing sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-9, and sh-Polypeptide-11, the ingredient’s maker reports appearance improvement of 10% at two weeks and 21% at four weeks.

For the material containing sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-9, and sh-Polypeptide-11, the ingredient’s maker reports a below-eye wrinkle image-analysis measure improved 38% at two weeks and 46% at four weeks.

See the five-factor findings.

Expression-Line Peptide in NeoTight Rejuvenating

NeoTight® Rejuvenating Anti-Wrinkle Serum by SeneGence: a pale blue-and-white serum bottle with a blue orchid-decorated cap.
NeoTight® Rejuvenating Anti-Wrinkle Serum — the product example for this ingredient.

For softer-looking expression lines and smoother, less shiny-looking skin, NeoTight® Rejuvenating Anti-Wrinkle Serum contains Dipeptide Diaminobutyroyl Benzylamide Diacetate.

the science

For Dipeptide Diaminobutyroyl Benzylamide Diacetate, the ingredient’s maker reports statistically significant improvement in forehead wrinkles at day 28 and in mouth-frown lines, upper-lip vertical lines, and forehead gloss at day 7 in a 150-woman placebo-controlled facial study across three skin-tone groups using 4% material twice daily.

The evidence page also covers user-reported smoothness and shine plus the manufacturer’s cell and biochemical work. Read the dipeptide evidence.

Palmitoyl Tripeptide-1 in Skin and Lip Care

For smoother-looking renewal, Advanced SenePlex+® Renewal Serum with Retinol pairs Palmitoyl Tripeptide-1 with Palmitoyl Tetrapeptide-7.

For hydrated, smoother, fuller-looking lips, LipSense® Long-Lasting Lip Liner Pencil carries Palmitoyl Tripeptide-1 in a separate lip-care context.

how to use it

Choose by zone and finish: Advanced Renewal is a facial treatment serum, while Lip Liner gives precise definition with conditioning lip care.

the science

The maker of this peptide pair combines Palmitoyl Tripeptide-1 with Palmitoyl Tetrapeptide-7 for smoother-looking skin and visible repair; each peptide carries palmitic acid, the palmitoyl in its name.

See the smoothing pair.

For the full Ethylhexyl Palmitate, Tribehenin, Sorbitan Isostearate, and Palmitoyl Tripeptide-1 material, the ingredient’s maker reports hydration 60% higher, superficial wrinkles 29% lower, and 40.7% higher average lip volume at day 29 in an uncontrolled 10-woman study of a colorless lipstick containing 1% material, used three times daily.

For the full Ethylhexyl Palmitate, Tribehenin, Sorbitan Isostearate, and Palmitoyl Tripeptide-1 material, the ingredient’s maker reports that the 10 participants noticed improved lip condition and smoothness with less flaking at day 29 after using the 1% material colorless lipstick three times daily.

Read the lip-care study.

The Lip Line Corrector Peptide Pair

Lip Line Corrector by SeneGence: a white pump bottle of lip care.
Lip Line Corrector — the product example for this ingredient.

For smoother-looking deep lip-area folds and plumper-looking contours, Lip Line Corrector pairs Palmitoyl Tetrapeptide-50 with Heptapeptide-15 Palmitate.

how to use it

Use it as the targeted lip-area step when the look of vertical lines and deeper folds beside the mouth leads your choice.

the science

For the exact two-peptide material containing Palmitoyl Tetrapeptide-50 and Heptapeptide-15 Palmitate, the ingredient’s maker reports up to 70% lower image-analyzed appearance of deep folds beside the mouth, visible by day 14, in a 28-day study of five adults using 1% material.

See the deep-fold evidence.

Myristoyl Pentapeptide-17 in LashExtend

LashExtend by SeneGence: a small clear lash-treatment tube with a gold cap.
LashExtend — the product example for this ingredient.

For denser, fuller-looking lashes, LashExtend contains Myristoyl Pentapeptide-17.

how to use it

Choose LashExtend as the dedicated lash-serum format, applied at the lash base morning and evening as directed until the desired result.

the science

For Myristoyl Pentapeptide-17, the ingredient’s maker reports induction of hair-specific keratin genes after 48 hours in an in vitro human keratinocyte assay using 0.001% neat material.

For Myristoyl Pentapeptide-17, the ingredient maker’s conclusion slide reports increasing lash density through day 42, with values of 33.67% at day 14, 46.71% at day 28, and 60.60% at day 42 in a four-person uncontrolled lash-root study testing 5% and 10% supplier-material eyeliner serums once nightly; allocation between strengths and whether or how the conclusion series combines them are not disclosed.

For Myristoyl Pentapeptide-17, the ingredient’s maker labels a single right-eyelash image series for its 10% supplier-material eyeliner-serum example with increases of 46.26% at day 14, 66.3% at day 28, and 72.29% at day 42.

See the lash-peptide evidence.

Biotinoyl Tripeptide-1 with Panthenol in UnderSense

UnderSense® 3-in-1 Maximizing Lash Primer by SeneGence: a pale blue lash-primer tube with a gold cap.
UnderSense® 3-in-1 Maximizing Lash Primer — the product example for this ingredient.

For longer-, fuller-, stronger-looking lash support, UnderSense® 3-in-1 Maximizing Lash Primer contains Biotinoyl Tripeptide-1.

how to use it

Apply UnderSense to top and bottom lashes, add coats for more buildable length and volume, and let it fully dry before finishing with one VolumeIntense mascara.

the science

The manufacturer material combines Glycerin, Water, Panthenol, and Biotinoyl Tripeptide-1.

For longer-, fuller-, stronger-looking lashes, the ingredient’s maker builds Biotinoyl Tripeptide-1 into a full ingredient combination with Glycerin, Water and Panthenol, according to its current summary.

See the lash-support role.

Oligopeptide-10 and Skin-Clarity Research

UnderSense® 3-in-1 Maximizing Lash Primer also carries Oligopeptide-10, and its ingredient maker reports cosmetic skin-clarity research for this exact peptide.

how to use it

In your routine, UnderSense supplies a light-beige preparation layer, buildable volume and length, and a base for mascara. Let it fully dry before the color finish.

the science

For Oligopeptide-10, the ingredient’s maker reports C. acnes activity and improved appearance of blemishes and red blotchy spots in an ingredient-research summary based on data on file.

Read the Oligopeptide-10 research.

Copper Peptide in DayTime Moisturizers

For firming and line care in daytime moisture, look for Bis(Tripeptide-1) Copper Acetate in DayTime Moisturizer - Dry, DayTime Moisturizer - Normal to Dry, and DayTime Moisturizer - Normal to Oily.

how to use it

Choose one DayTime texture for your skin: richer comfort for Dry, balanced hydration for Normal to Dry, or hydration with a more matte T-zone for Normal to Oily.

the science

The ingredient manufacturer makes Bis(Tripeptide-1) Copper Acetate for firmer-looking skin and wrinkle care and points to several controlled facial studies.

See the copper-peptide source.

Acetyl Hexapeptide-8 in Translucent Loose Powder

Translucent Loose Powder by SeneGence: an open loose-powder jar beside a gold lid bearing the SeneGence emblem.
Translucent Loose Powder — the product example for this ingredient.

Translucent Loose Powder creates a soft-focus setting finish. Its formula also includes Acetyl Hexapeptide-8.

how to use it

Pick up the loose powder with a brush and apply where you want a soft-focus finish.

the science

The manufacturer studies used leave-on cream test articles, while Translucent Loose Powder is the current SeneGence formula where this exact INCI appears.

For Acetyl Hexapeptide-8, the ingredient’s maker reports 20.6% lower wrinkle volume and 15.9% lower wrinkle length at day 7 in a randomized split-face placebo study of 22 women using a leave-on cream with 2% supplier solution twice daily.

For Acetyl Hexapeptide-8, the ingredient’s maker reports wrinkle roughness 20.4% lower at day 28 in an uncontrolled instrumental study of 18 women using a leave-on cream with 5% supplier solution twice daily.

For Acetyl Hexapeptide-8, the ingredient’s maker reports up to 32% lower glutamate release at 2 mM in an in vitro assay.

Read the Acetyl Hexapeptide-8 studies.

Choose a Peptide Routine by Goal

Start with the change you want to see, then find the formula that carries the matching peptide.

Lines and firmness
GLP Complex™ with SenePlex+® and Exosomes, SeneCell™ SenePlex+® StemCell Concentrate and MakeSense® Silk Primer & Pore Minimizer carry Caprooyl Tetrapeptide-3; NeoTight® Rejuvenating Anti-Wrinkle Serum targets expression lines with Dipeptide Diaminobutyroyl Benzylamide Diacetate; each DayTime Moisturizer adds copper-peptide firming care.
Even tone
The six DayTime and Evening Moisturizers carry the two-peptide tone pair.
Night care
Evening Moisturizer - Dry, Normal to Dry or Normal to Oily brings the plant-produced fusion peptide; Advanced SenePlex+® Renewal Serum with Retinol adds multi-factor renewal.
Lips
LipSense® Long-Lasting Lip Liner Pencil carries Palmitoyl Tripeptide-1 for hydrated, smoother, fuller-looking lips.
Lip-line folds
Lip Line Corrector pairs Palmitoyl Tetrapeptide-50 with Heptapeptide-15 Palmitate.
Brows and hair
BrowSense® Volumizing Brow Gel and HairCovery® Strengthening & Thickening Hair Serum carry Acetyl Tetrapeptide-3 with clover.
Lashes
LashExtend carries Myristoyl Pentapeptide-17 for denser, fuller-looking lashes. UnderSense® 3-in-1 Maximizing Lash Primer brings Biotinoyl Tripeptide-1 and Acetyl Tetrapeptide-3 with clover; once it dries, finish with LashSense® VolumeIntense® Mascara for humidity- and smudge-resistant color or LashSense® VolumeIntense® Waterproof Mascara when sweat, tears or water resistance matters.
how to use it

Choose one product for each goal and follow its own directions. See the complete skincare order for where each facial step goes.

the science

Study results at a glance

Caprooyl Tetrapeptide-3 with Dextran — wrinkle and skin-support studies8 results
Caprooyl Tetrapeptide-3 with Dextran — wrinkle and skin-support studies
ResultKind of resultWhen it was measured
In an in vitro fibroblast assay of Caprooyl Tetrapeptide-3, the ingredient’s maker reports laminin 26% higher and fibronectin 60% higher after 48 hours.Ingredient study48 hours
In a corticoid-stressed four-donor human-skin explant model of Caprooyl Tetrapeptide-3, the ingredient’s maker reports collagen VII staining 34% higher and laminin-5 staining 49% higher versus corticoid alone at day 3.Ingredient studyday 3
In the corticoid-stressed four-donor human-skin explant model, the ingredient’s maker reports that Caprooyl Tetrapeptide-3 helped prevent the dermal-epidermal-junction flattening seen with corticoid alone at day 3.Ingredient studyday 3
The ingredient’s maker reports 16% average improvement in fine-line and wrinkle appearance at day 28 in a randomized split-temple serum study of Glycerin, Water, Dextran, and Caprooyl Tetrapeptide-3.Ingredient studyday 28
In the same randomized split-temple serum study, the ingredient’s maker reports that the full Glycerin, Water, Dextran, and Caprooyl Tetrapeptide-3 material improved fine-line and wrinkle appearance by up to 29% at day 28.Ingredient studyday 28
Show 3 more results
Caprooyl Tetrapeptide-3 with Dextran — wrinkle and skin-support studies, more results
ResultKind of resultWhen it was measured
In the age-defined 50–65 subgroup of the same 27-woman randomized split-temple serum study of the full Glycerin, Water, Dextran, and Caprooyl Tetrapeptide-3 material, the ingredient’s maker reports 27% average and up to 35% improvement in fine-line and wrinkle appearance at day 56.Ingredient studyday 56
In a separate 30-woman self-assessment of a serum with 2.5% of the full Glycerin, Water, Dextran, and Caprooyl Tetrapeptide-3 material used twice daily, the ingredient’s maker reports favorable perceptions of smoothness, firmness, evenness, and a rested look at day 56, plus favorable eye-area tolerability.Participant feedbackday 56
In a 27-woman split-temple ultrasound study of a serum with 2.5% of the full Glycerin, Water, Dextran, and Caprooyl Tetrapeptide-3 material used twice daily, the ingredient’s maker reports improvement versus placebo in 78% of participants on the upper-dermis entropy measure at day 168.Ingredient studyday 168
Who took part
Human instrumental study: 27 women ages 40–65; self-assessment: 30 women ages 40–65; explant work: four human skin specimens
How it was evaluated
In vitro fibroblast work; four-donor stressed skin-explant work; randomized split-temple serum comparisons measured by silicone-replica profilometry and ultrasound; and a 30-woman self-assessment
Statistical context
The manufacturer-authored article reports day-28 wrinkle-appearance improvement in its randomized split-temple serum study.

See the full finding: Caprooyl Tetrapeptide-3 with Dextran — wrinkle and skin-support studies

Acetyl Tetrapeptide-3 with Clover and Dextran — hair and lash studies8 results
Acetyl Tetrapeptide-3 with Clover and Dextran — hair and lash studies
ResultKind of resultWhen it was measured
For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, the ingredient’s maker reports follicle elongation 58%, 51%, and 87% higher than untreated follicles at days 4, 7, and 11 in an ex vivo assay of 22 treated and 34 untreated follicles from one donor using 1% material.Measured resultday 4; day 7; day 11
For exact Acetyl Tetrapeptide-3, the ingredient’s maker reports 47% greater elongation than untreated follicles at day 7 in an ex vivo assay of 15 peptide-treated, 27 minoxidil-reference, and 27 untreated follicles; its stated reference comparison belongs only to that assay.Measured resultday 7
For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, the ingredient’s maker reports mean anagen density 9% higher, mean telogen density 42% lower, and anagen-to-telogen ratio 88% higher at day 90 in a 23-person baseline-controlled rinse-off scalp study using 1.5% material in shampoo and conditioner every two days.Measured resultday 90
For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, the ingredient’s maker reports the two specified Cutibacterium acnes scalp-microbiome ratios 36% and 62% lower at day 90 in 21 people using the rinse-off regimen.Measured resultday 90
For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, the ingredient’s maker reports a 15% favorable anagen-density delta, 52% favorable telogen-density delta, and 79-point between-group anagen-to-telogen-ratio delta after four months in a randomized 29-person leave-on scalp study using 5% material nightly.Measured resultfour months
Show 3 more results
Acetyl Tetrapeptide-3 with Clover and Dextran — hair and lash studies, more results
ResultKind of resultWhen it was measured
For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, the ingredient’s maker reports up to 27% lash-density improvement with a 93% responder rate at week 8 in a 17-woman split-eye study of a 2.5% material gel versus opposite-eye placebo, used morning and evening.Measured resultweek 8
For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, the ingredient’s maker reports 45.5% more new lashes on the active side at week 8 while the placebo side recorded no new lashes in the same 17-woman split-eye study.Measured resultweek 8
For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, the ingredient’s maker reports lash length increased by up to 0.70 mm at week 4 in the same 17-woman split-eye study and puts the active-side improvement at three times placebo at week 4 and five times placebo at week 8.Measured resultweek 4; week 8
Who took part
Human studies included 29 leave-on participants, 23 rinse-off participants, 21 microbiome participants, and 17 split-eye lash participants
How it was evaluated
Randomized leave-on scalp study, baseline-controlled rinse-off scalp work, scalp-microbiome analysis, split-eye lash imaging, and ex vivo human-hair-follicle assays
Statistical context
Across distinct studies, the ingredient’s maker reports fuller-looking hair and lashes, scalp-microbiome changes, and follicle elongation.

See the full finding: Acetyl Tetrapeptide-3 with Clover and Dextran — hair and lash studies · Open the source document (PDF)

Nicotiana fusion peptide — 28-day skin-appearance study10 results
Nicotiana fusion peptide — 28-day skin-appearance study
ResultKind of resultWhen it was measured
For Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer reports increased expression of selected genes associated with epidermal lipids and barrier function after 24 and 48 hours in primary human keratinocytes exposed to 20 ng/mL active, stated as 2% material.Ingredient study24 hours; 48 hours
For Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer reports dose-responsive collagen I after 48 hours in adult human dermal fibroblasts and describes its assay-specific potency as four times the retinol reference.Ingredient study48 hours
For Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer reports qualitative increases in epidermal thickness and lipid staining at day 8 in an exploratory human-skin explant from one 52-year-old donor treated with a cream containing 1.5% material.Ingredient studyday 8
In a 20-woman, placebo-controlled split-face study of Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer used a preparation containing 2% material, applied twice daily. At day 28, it reported 16% lower wrinkle count, 11% lower wrinkle volume and 14% lower wrinkle depth across the full study group. Within the separate 85% responder group, wrinkle depth was 19.4% lower on average.Measured resultday 28
For Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer reports whole-cohort firmness 11% higher and elasticity 6% higher at day 28 in the 20-woman placebo-controlled split-face study using 2% material twice daily; the 95% responder subsets averaged 12.6% and 6.1% higher.Measured resultday 28
Show 5 more results
Nicotiana fusion peptide — 28-day skin-appearance study, more results
ResultKind of resultWhen it was measured
For Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer reports whole-cohort pore diameter 11.6% lower at day 28 in the 20-woman placebo-controlled split-face study; the 80% responder subset averaged 16.2% lower, with improvement up to 44%.Measured resultday 28
For Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer reports whole-cohort radiance 12.5% higher at day 28 in the 20-woman placebo-controlled split-face study; the 90% responder subset averaged 14.4% higher, with improvement up to 42%.Measured resultday 28
For Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer reports whole-cohort hydration 12.4% higher and transepidermal water loss 9.5% lower at day 28 in the 20-woman placebo-controlled split-face study; hydration had 100% responders, while the 90% water-loss responder subset averaged 11.2% lower.Measured resultday 28
For Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer reports whole-cohort skin roughness 6.9% lower at day 28 in the 20-woman placebo-controlled split-face study; the 75% responder subset averaged 12.6% lower, with improvement up to 26%.Measured resultday 28
For Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer reports skin thickness 8.0% higher among the 85% responder subset at day 28 in the 20-woman placebo-controlled split-face ultrasound study, with improvement up to 16%.Measured resultday 28
Who took part
Human study: 20 women ages 45–65 using 2% supplier material twice daily for 28 days
How it was evaluated
Keratinocyte and fibroblast assays, a human skin-explant model, and a 20-woman placebo-controlled split-face study using instrumental wrinkle, firmness, pore, radiance, hydration, and water-loss measures
Statistical context
Across the human study, the ingredient manufacturer reports improvements in wrinkles, firmness, radiance, pores, hydration, and water loss at day 28.

See the full finding: Nicotiana fusion peptide — 28-day skin-appearance study · Open the source document (PDF)

Five sh-Oligopeptide and sh-Polypeptide factors in Advanced SenePlex+ Renewal Serum2 results
Five sh-Oligopeptide and sh-Polypeptide factors in Advanced SenePlex+ Renewal Serum
ResultKind of resultWhen it was measured
Using PRIMOS Lite 3D to measure crow’s-feet after use of a cosmetic formula containing sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-9, and sh-Polypeptide-11, the ingredient’s maker reports appearance improvement of 10% at two weeks and 21% at four weeks.Measured resulttwo weeks; four weeks
For the material containing sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-9, and sh-Polypeptide-11, the ingredient’s maker reports a below-eye wrinkle image-analysis measure improved 38% at two weeks and 46% at four weeks.Measured resulttwo weeks; four weeks
Who took part
The public brochure does not disclose sample size, material concentration, comparator, or cadence
How it was evaluated
PRIMOS Lite 3D crow’s-feet measurement and a separate below-eye wrinkle image-analysis measure; public protocol is incomplete
Statistical context
The ingredient’s maker reports improvement in crow’s-feet and a separate below-eye wrinkle measure over four weeks.

See the full finding: Five sh-Oligopeptide and sh-Polypeptide factors in Advanced SenePlex+ Renewal Serum · Open the source document (PDF)

Dipeptide Diaminobutyroyl Benzylamide Diacetate — expression-line study4 results
Dipeptide Diaminobutyroyl Benzylamide Diacetate — expression-line study
ResultKind of resultWhen it was measured
For Dipeptide Diaminobutyroyl Benzylamide Diacetate, the ingredient’s maker reports up to 3.5-fold PLOD3 gene-expression induction after 24 hours in fibroblasts from a 63-year-old donor exposed to the exact peptide; this is an in vitro mechanism endpoint.Measured result24 hours
For Dipeptide Diaminobutyroyl Benzylamide Diacetate, the ingredient’s maker reports statistically significant improvement in forehead wrinkles at day 28 and in mouth-frown lines, upper-lip vertical lines, and forehead gloss at day 7 in a 150-woman placebo-controlled facial study across three skin-tone groups using 4% material twice daily.Ingredient studyday 7 for mouth-frown lines, upper-lip vertical lines, and forehead gloss; day 28 for forehead wrinkles
For Dipeptide Diaminobutyroyl Benzylamide Diacetate, the ingredient’s maker reports day-28 active-cohort agreement for smoother, less shiny, and more beautiful-looking skin across the three skin-tone groups, plus 83% average confidence agreement among 75 users.Participant feedbackday 28
For Dipeptide Diaminobutyroyl Benzylamide Diacetate, the ingredient’s maker reports dose-dependent DPP4 inhibition from 0.8 to 100 ppm in a cell-free biochemical assay.Measured resultassay time not disclosed
Who took part
Human study: 150 women ages 40–64 across three skin-tone groups; active self-assessment subset: 75 participants
How it was evaluated
In vitro gene-expression and biochemical assays; randomized 28-day parallel-group facial study; and active-cohort self-assessment
Statistical context
The manufacturer reports statistically significant improvement in forehead wrinkles at day 28 and in mouth-frown lines, upper-lip vertical lines, and forehead gloss at day 7.

See the full finding: Dipeptide Diaminobutyroyl Benzylamide Diacetate — expression-line study · Open the source document (PDF)

Palmitoyl Tripeptide-1 — 29-day lip-care study2 results
Palmitoyl Tripeptide-1 — 29-day lip-care study
ResultKind of resultWhen it was measured
For the full Ethylhexyl Palmitate, Tribehenin, Sorbitan Isostearate, and Palmitoyl Tripeptide-1 material, the ingredient’s maker reports hydration 60% higher, superficial wrinkles 29% lower, and 40.7% higher average lip volume at day 29 in an uncontrolled 10-woman study of a colorless lipstick containing 1% material, used three times daily.Measured resultday 29
For the full Ethylhexyl Palmitate, Tribehenin, Sorbitan Isostearate, and Palmitoyl Tripeptide-1 material, the ingredient’s maker reports that the 10 participants noticed improved lip condition and smoothness with less flaking at day 29 after using the 1% material colorless lipstick three times daily.Ingredient studyday 29
Who took part
10 women ages 20–40 with thin, small, dry lips
How it was evaluated
Human instrumental measures, dermatologist assessment, and participant observation without a separate placebo
Statistical context
The ingredient’s maker reports changes in hydration, superficial lip wrinkles, average lip volume, smoothness, and flaking after 29 days.

See the full finding: Palmitoyl Tripeptide-1 — 29-day lip-care study

Lip Line Corrector Peptide Pair: What the Palmitoyl Tetrapeptide-50 and Heptapeptide-15 Palmitate Deep-Fold Study Found1 result
Lip Line Corrector Peptide Pair: What the Palmitoyl Tetrapeptide-50 and Heptapeptide-15 Palmitate Deep-Fold Study Found
ResultKind of resultWhen it was measured
For the exact two-peptide material containing Palmitoyl Tetrapeptide-50 and Heptapeptide-15 Palmitate, the ingredient’s maker reports up to 70% lower image-analyzed appearance of deep folds beside the mouth, visible by day 14, in a 28-day study of five adults using 1% material.Measured resultday 14; day 28
Who took part
Five adults ages 49–60
How it was evaluated
Human instrumental image analysis at days 14 and 28
Statistical context
The ingredient’s maker reports visible change by day 14 in its five-adult deep-fold study.

See the full finding: Lip Line Corrector Peptide Pair: What the Palmitoyl Tetrapeptide-50 and Heptapeptide-15 Palmitate Deep-Fold Study Found · Open the source document (PDF)

Myristoyl Pentapeptide-17 — lash-density and keratin-gene studies3 results
Myristoyl Pentapeptide-17 — lash-density and keratin-gene studies
ResultKind of resultWhen it was measured
For Myristoyl Pentapeptide-17, the ingredient’s maker reports induction of hair-specific keratin genes after 48 hours in an in vitro human keratinocyte assay using 0.001% neat material.Ingredient study48 hours
For Myristoyl Pentapeptide-17, the ingredient maker’s conclusion slide reports increasing lash density through day 42, with values of 33.67% at day 14, 46.71% at day 28, and 60.60% at day 42 in a four-person uncontrolled lash-root study testing 5% and 10% supplier-material eyeliner serums once nightly; allocation between strengths and whether or how the conclusion series combines them are not disclosed.Measured resultday 14; day 28; day 42
For Myristoyl Pentapeptide-17, the ingredient’s maker labels a single right-eyelash image series for its 10% supplier-material eyeliner-serum example with increases of 46.26% at day 14, 66.3% at day 28, and 72.29% at day 42.Measured resultday 14; day 28; day 42
Who took part
Human study: four people across 5% and 10% supplier-material conditions; the conclusion slide does not assign its result series to either strength. A separate 10% image sequence is labeled as one example.
How it was evaluated
In vitro human keratinocyte gene-expression assay; uncontrolled four-person lash-root image study; and one separately labeled 10% example image series
Statistical context
The ingredient’s maker reports increasing lash density through day 42 in its four-person study and provides one separately labeled 10% example image series.

See the full finding: Myristoyl Pentapeptide-17 — lash-density and keratin-gene studies · Open the source document (PDF)

Acetyl Hexapeptide-8 — split-face wrinkle studies3 results
Acetyl Hexapeptide-8 — split-face wrinkle studies
ResultKind of resultWhen it was measured
For Acetyl Hexapeptide-8, the ingredient’s maker reports 20.6% lower wrinkle volume and 15.9% lower wrinkle length at day 7 in a randomized split-face placebo study of 22 women using a leave-on cream with 2% supplier solution twice daily.Measured resultday 7
For Acetyl Hexapeptide-8, the ingredient’s maker reports wrinkle roughness 20.4% lower at day 28 in an uncontrolled instrumental study of 18 women using a leave-on cream with 5% supplier solution twice daily.Measured resultday 28
For Acetyl Hexapeptide-8, the ingredient’s maker reports up to 32% lower glutamate release at 2 mM in an in vitro assay.Measured resultassay duration not disclosed
Who took part
Human studies: 22 women in the seven-day split-face study and 18 women in the 28-day study
How it was evaluated
In vitro glutamate-release assay; seven-day randomized split-face placebo comparison; and 28-day uncontrolled instrumental roughness study
Statistical context
The ingredient’s maker reports wrinkle-volume and wrinkle-length changes by day 7 and wrinkle-roughness change by day 28 in its ingredient studies.

See the full finding: Acetyl Hexapeptide-8 — split-face wrinkle studies · Open the source document (PDF)

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