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clinical finding

Dipeptide Diaminobutyroyl Benzylamide Diacetate — expression-line study

in the study

Manufacturer studies of Dipeptide Diaminobutyroyl Benzylamide Diacetate

what it showed

The ingredient’s maker reports statistically significant improvement in forehead wrinkles at day 28 and in mouth-frown lines, upper-lip vertical lines, and forehead gloss at day 7; day-28 self-assessment separately included 83% average confidence agreement among 75 users.

You will find this exact peptide in NeoTight® Rejuvenating Anti-Wrinkle Serum.

In NeoTight® Rejuvenating Anti-Wrinkle Serum, this peptide contributes care for softer-looking expression lines, smoother-looking skin, and less visible shine.

By SeneGence · Alan Kante, publisher · Updated

What supports Dipeptide Diaminobutyroyl Benzylamide Diacetate?

5 details
How it was evaluated
In vitro gene-expression and biochemical assays; randomized 28-day parallel-group facial study; and active-cohort self-assessment
Who took part
Human study: 150 women ages 40–64 across three skin-tone groups; active self-assessment subset: 75 participants
Statistical context
The manufacturer reports statistically significant improvement in forehead wrinkles at day 28 and in mouth-frown lines, upper-lip vertical lines, and forehead gloss at day 7.
Information checked
2026-09-14

Measured results · day 7 for mouth-frown lines, upper-lip vertical lines, and forehead gloss; day 28 for forehead wrinkles

Forehead wrinkles, mouth-frown lines, upper-lip vertical lines, and forehead gloss

statistically significant improvement in selected wrinkle and gloss endpoints

For Dipeptide Diaminobutyroyl Benzylamide Diacetate, the ingredient’s maker reports statistically significant improvement in forehead wrinkles at day 28 and in mouth-frown lines, upper-lip vertical lines, and forehead gloss at day 7 in a 150-woman placebo-controlled facial study across three skin-tone groups using 4% material twice daily.

When it was measured
day 7 for mouth-frown lines, upper-lip vertical lines, and forehead gloss; day 28 for forehead wrinkles

Participant feedback · day 28

Smoothness, shine, beauty, and confidence

smoother, less shiny, and more beautiful-looking skin

For Dipeptide Diaminobutyroyl Benzylamide Diacetate, the ingredient’s maker reports day-28 active-cohort agreement for smoother, less shiny, and more beautiful-looking skin across the three skin-tone groups, plus 83% average confidence agreement among 75 users.

What was measured
visible smoothness, shine, beauty, and confidence
When it was measured
day 28

Measured results · 24 hours

PLOD3 gene expression

up to 3.5-fold PLOD3 gene-expression induction

For Dipeptide Diaminobutyroyl Benzylamide Diacetate, the ingredient’s maker reports up to 3.5-fold PLOD3 gene-expression induction after 24 hours in fibroblasts from a 63-year-old donor exposed to the exact peptide; this is an in vitro mechanism endpoint.

When it was measured
24 hours

Measured results · assay time not disclosed

DPP4 inhibition

dose-dependent DPP4 inhibition

For Dipeptide Diaminobutyroyl Benzylamide Diacetate, the ingredient’s maker reports dose-dependent DPP4 inhibition from 0.8 to 100 ppm in a cell-free biochemical assay.

When it was measured
assay time not disclosed

In the formula

Dipeptide Diaminobutyroyl Benzylamide Diacetate — expression-line study

NeoTight® Rejuvenating Anti-Wrinkle Serum contains Dipeptide Diaminobutyroyl Benzylamide Diacetate, a synthetic peptide studied for expression-line appearance and reduced forehead shine. Beside it are Porphyridium Cruentum Extract and the Methylglucoside Phosphate and Copper Lysinate/Prolinate combination.