What are the benefits of NeoTight Rejuvenating Anti-Wrinkle Serum?
Quick answer
SeneGence NeoTight® Rejuvenating Anti-Wrinkle Serum is a targeted facial treatment for firmness, lift and visibly softened lines, with Copper Lysinate/Prolinate and Methylglucoside Phosphate, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Porphyridium Cruentum (Red Algae) Extract and SenePlex+®. In an independent study, Rejuvenating Anti-Wrinkle Serum improved measured net skin elasticity by 7.65% one hour after a single application. See the elasticity study. After six weeks of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 24.53% average improvement in the appearance of crow’s feet.
By SeneGence · 
Alan Kante, publisher · Updated
- 2 min read
- SenePlex+®
- Peptides
How fast does NeoTight Rejuvenating Anti-Wrinkle Serum work?
Within an hour, and it keeps building. NeoTight® Rejuvenating Anti-Wrinkle Serum improved measured elasticity and firmer-looking skin within an hour of one application; after six weeks, expression lines looked improved and participants reported firmer-feeling skin. See the NeoTight Rejuvenating clinical report. One hour after a single application of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 12.05% average improvement in firmer-looking skin. See every result. At week 6, 84.38% of participants agreed that NeoTight® Rejuvenating Anti-Wrinkle Serum reduced the appearance of fine lines and wrinkles. The Beauty Book reports its own one-hour result separately. NeoTight® Rejuvenating Anti-Wrinkle Serum gives a firmer-looking, visibly lifted appearance within one hour after a single application, measured by expert graded observation compared with baseline in 33 women ages 30–70. It reduces the look of fine lines and wrinkles around the eyes, mouth and forehead and supports a smooth, hydrated, rejuvenated-looking complexion. Beauty Book 2026 (p. 18).
What is inside NeoTight Rejuvenating Anti-Wrinkle Serum?
For a plumper, more youthful appearance, Methylglucoside Phosphate with Copper Lysinate/Prolinate, proline and lysine supports collagen and elastin in NeoTight® Rejuvenating Anti-Wrinkle Serum. Dipeptide Diaminobutyroyl Benzylamide Diacetate smooths the look of fine lines and wrinkles and reduces shine. Porphyridium Cruentum (Red Algae) Extract gives an instant tightening effect. See the expression-line peptide study. It also carries SenePlex+®.
How do I use it?
Apply AM and PM to targeted expression lines. Follow with moisturizer. After cleansing, smooth it over the mouth, eye and forehead areas morning and evening, then follow with DayTime or Evening Moisturizer. For dedicated under-eye and eyelid care, add NeoTight™ Eye Serum, and for overnight renewal, see Advanced SenePlex+® Renewal Serum with Retinol. NeoTight Rejuvenating Anti-Wrinkle Serum.
Benefits, formula & use
NeoTight® Rejuvenating Anti-Wrinkle Serum
- Benefits
- Choose NeoTight® Rejuvenating Anti-Wrinkle Serum to reduce the appearance of fine lines and wrinkles around the eyes, mouth and forehead for a firmer-looking, visibly lifted, smoother complexion.
- Application
- Following cleansing, apply 1-2 pumps twice a day concentrating on the mouth, eye, and forehead areas. Follow with DayTime or Evening Moisturizer. Caution: For external use only. Avoid contact with eyes.
- Good For
- NeoTight® Rejuvenating Anti-Wrinkle Serum suits all skin types with fine lines, wrinkles, crepey skin & loss of firmness.
SeneGence Beauty Book 2026, p. 18 · Current formula and directions: official SeneGence product page · View NeoTight® Rejuvenating Anti-Wrinkle Serum on SeneGence
NeoTight® Rejuvenating Anti-Wrinkle Serum
Choose NeoTight® Rejuvenating Anti-Wrinkle Serum to reduce the appearance of fine lines and wrinkles around the eyes, mouth and forehead for a firmer-looking, visibly lifted, smoother complexion.
SenePlex+®NeoTight® Rejuvenating Anti-Wrinkle Serum suits all skin types with fine lines, wrinkles, crepey skin & loss of firmness.
How to use NeoTight® Rejuvenating Anti-Wrinkle Serum
Following cleansing, apply 1-2 pumps twice a day concentrating on the mouth, eye, and forehead areas. Follow with DayTime or Evening Moisturizer. Caution: For external use only. Avoid contact with eyes.
Read the ingredients
Aqua/Water/Eau Glycerin Dimethicone Coconut Alkanes Butylene Glycol Cetyl PEG/PPG-10/1 Dimethicone Hydroxypropyl Methylcellulose Dimethicone/Vinyl Dimethicone Crosspolymer PEG/PPG-18/18 Dimethicone Coco-Caprylate Sodium Chloride Persea Gratissima (Avocado) Oil Porphyridium Cruentum (Red Algae) Extract Raphanus Sativus (Radish) Leaf Extract Aloe Barbadensis (Aloe Vera) Leaf Juice Laminaria Digitata (Kelp) Extract Saccharomyces Cerevisiae (Yeast) Extract Orchis Mascula (Orchid) Flower Extract Hydrogenated Vegetable Oil Sodium Hyaluronate Tocopherol Panthenol Tocopheryl Acetate Dimethicone/PEG-10/15 Crosspolymer Pullulan Squalane Ethylhexylglycerin Phospholipids Methylglucoside Phosphate Citric Acid Copper Lysinate/Prolinate Gluconolactone Dipeptide Diaminobutyroyl Benzylamide Diacetate Trisodium Ethylenediamine Disuccinate Dipropylene Glycol Sodium Citrate Urea* Glucosamine HCl Sodium Benzoate Potassium Sorbate Phenoxyethanol Parfum/Fragrance Benzyl Alcohol Benzyl Salicylate Alpha-Isomethyl Ionone Citronellol. *Synthetic
Study results at a glance
NeoTight® Rejuvenating Anti-Wrinkle Serum — one-hour and six-week study20 results
| Result | Kind of result | When it was measured |
|---|---|---|
| In an independent study, Rejuvenating Anti-Wrinkle Serum improved measured net skin elasticity by 7.65% one hour after a single application. | Measured result | baseline to 1 hour after a single application |
| One hour after a single application of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 12.05% average improvement in firmer-looking skin. | Expert assessment | 1 hour after a single application |
| At week 6, 84.38% of participants agreed that they liked how their skin felt immediately after applying Rejuvenating Anti-Wrinkle Serum. | Participant feedback | week-6 questionnaire about immediate application feel |
| After six weeks of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 24.53% average improvement in the appearance of crow’s feet. | Expert assessment | 6 weeks |
| After six weeks of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 13.64% average improvement in the appearance of upper-lip lines. | Expert assessment | 6 weeks |
Show 15 more results
| Result | Kind of result | When it was measured |
|---|---|---|
| After six weeks of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 7.14% average improvement in the appearance of nasolabial folds. | Expert assessment | 6 weeks |
| At week 6, 96.88% of participants agreed that Rejuvenating Anti-Wrinkle Serum hydrated their skin well. | Participant feedback | 6 weeks |
| At week 6, 87.50% of participants agreed that Rejuvenating Anti-Wrinkle Serum improved their skin's overall appearance. | Participant feedback | 6 weeks |
| At week 6, 84.38% of participants agreed that NeoTight® Rejuvenating Anti-Wrinkle Serum reduced the appearance of fine lines and wrinkles. | Participant feedback | 6 weeks |
| At week 6, 78.13% of participants agreed that NeoTight® Rejuvenating Anti-Wrinkle Serum reduced the appearance of crow's feet around the eyes. | Participant feedback | 6 weeks |
| At week 6, 62.50% of participants agreed that NeoTight® Rejuvenating Anti-Wrinkle Serum reduced the appearance of nasolabial folds. | Participant feedback | 6 weeks |
| At week 6, 71.88% of participants agreed that NeoTight® Rejuvenating Anti-Wrinkle Serum reduced the appearance of upper-lip lines. | Participant feedback | 6 weeks |
| At week 6, 75.00% of participants agreed that their face appeared more youthful after using Rejuvenating Anti-Wrinkle Serum. | Participant feedback | 6 weeks |
| At week 6, 75.00% of participants agreed that their skin felt firmer after using Rejuvenating Anti-Wrinkle Serum. | Participant feedback | 6 weeks |
| At week 6, 71.88% of participants agreed that their skin appeared tighter after using Rejuvenating Anti-Wrinkle Serum. | Participant feedback | 6 weeks |
| At week 6, 96.88% of participants agreed that their skin tolerated Rejuvenating Anti-Wrinkle Serum well without sensitivities. | Participant feedback | 6 weeks |
| At week 6, 84.38% of participants agreed that they liked the color, texture, smell, and feel of Rejuvenating Anti-Wrinkle Serum. | Participant feedback | 6 weeks |
| At week 6, 71.88% of participants agreed that Rejuvenating Anti-Wrinkle Serum absorbed well and did not feel greasy or tacky. | Participant feedback | 6 weeks |
| At week 6, 87.50% of participants agreed that they liked Rejuvenating Anti-Wrinkle Serum overall. | Participant feedback | 6 weeks |
| At week 6, 71.88% of participants agreed that they noticed a firmer-looking, more lifted appearance after applying Rejuvenating Anti-Wrinkle Serum. | Participant feedback | week-6 questionnaire about appearance after application |
See the full finding: NeoTight® Rejuvenating Anti-Wrinkle Serum — one-hour and six-week study · Open the study PDF
Dipeptide Diaminobutyroyl Benzylamide Diacetate — expression-line study4 results
| Result | Kind of result | When it was measured |
|---|---|---|
| For Dipeptide Diaminobutyroyl Benzylamide Diacetate, the ingredient’s maker reports up to 3.5-fold PLOD3 gene-expression induction after 24 hours in fibroblasts from a 63-year-old donor exposed to the exact peptide; this is an in vitro mechanism endpoint. | Measured result | 24 hours |
| For Dipeptide Diaminobutyroyl Benzylamide Diacetate, the ingredient’s maker reports statistically significant improvement in forehead wrinkles at day 28 and in mouth-frown lines, upper-lip vertical lines, and forehead gloss at day 7 in a 150-woman placebo-controlled facial study across three skin-tone groups using 4% material twice daily. | Ingredient study | day 7 for mouth-frown lines, upper-lip vertical lines, and forehead gloss; day 28 for forehead wrinkles |
| For Dipeptide Diaminobutyroyl Benzylamide Diacetate, the ingredient’s maker reports day-28 active-cohort agreement for smoother, less shiny, and more beautiful-looking skin across the three skin-tone groups, plus 83% average confidence agreement among 75 users. | Participant feedback | day 28 |
| For Dipeptide Diaminobutyroyl Benzylamide Diacetate, the ingredient’s maker reports dose-dependent DPP4 inhibition from 0.8 to 100 ppm in a cell-free biochemical assay. | Measured result | assay time not disclosed |
See the full finding: Dipeptide Diaminobutyroyl Benzylamide Diacetate — expression-line study · Open the source document (PDF)
Full ingredient list
NeoTight® Rejuvenating Anti-Wrinkle SerumIngredient guide
Aqua/Water/Eau Glycerin Dimethicone Coconut Alkanes Butylene Glycol Cetyl PEG/PPG-10/1 Dimethicone Hydroxypropyl Methylcellulose Dimethicone/Vinyl Dimethicone Crosspolymer PEG/PPG-18/18 Dimethicone Coco-Caprylate Sodium Chloride Persea Gratissima (Avocado) Oil Porphyridium Cruentum (Red Algae) Extract Raphanus Sativus (Radish) Leaf Extract Aloe Barbadensis (Aloe Vera) Leaf Juice Laminaria Digitata (Kelp) Extract Saccharomyces Cerevisiae (Yeast) Extract Orchis Mascula (Orchid) Flower Extract Hydrogenated Vegetable Oil Sodium Hyaluronate Tocopherol Panthenol Tocopheryl Acetate Dimethicone/PEG-10/15 Crosspolymer Pullulan Squalane Ethylhexylglycerin Phospholipids Methylglucoside Phosphate Citric Acid Copper Lysinate/Prolinate Gluconolactone Dipeptide Diaminobutyroyl Benzylamide Diacetate Trisodium Ethylenediamine Disuccinate Dipropylene Glycol Sodium Citrate Urea* Glucosamine HCl Sodium Benzoate Potassium Sorbate Phenoxyethanol Parfum/Fragrance Benzyl Alcohol Benzyl Salicylate Alpha-Isomethyl Ionone Citronellol.
*Synthetic
Official product reference checked September 18, 2026. View NeoTight® Rejuvenating Anti-Wrinkle Serum on SeneGence