49.99%
immediate increase in hydration
After first use
Normal-to-Dry regimen
SeneGenceReviewTwo Independent SenePlex+ Skincare Studies
Hydration, radiance, firmness, and visible surface renewal
SenePlex+ Clinical Results
By SeneGence · Updated
Two independent studies measured SenePlex+ skincare: the Normal-to-Dry regimen from first use through Week 8, and Evening Moisturizer – Normal to Dry in a 20-day surface-renewal study.
Normal-to-Dry regimen · first use to Week 8Evening Moisturizer · 20 daysTwo independent studies
23.60%
improvement in visible radiance
Week 8
Normal-to-Dry regimen
Up to 100%
greater visible surface-cell turnover
Day 18
Evening Moisturizer Normal to Dry
Study design and limits
How these two studies were built, and what that means for reading their numbers.
- The eight-week regimen study was single-arm: 34 women enrolled, 32 completed, and everyone used 3 in 1 Cleanser, DayTime Moisturizer and Evening Moisturizer together. Each result compares skin with its own baseline rather than with an untreated group, and it belongs to the three-product regimen, not to one product alone.
- What participants noticed at Week 8 is self-reported agreement from 32 participants, kept apart from the instrument readings and expert grading.
- The 20-day Evening Moisturizer study compared a treated site with an untreated site on the same participants (34 enrolled, 33 completed). Its stain scoring reads visible turnover at the skin’s surface.
- The surface-renewal laboratory summary is marked as preliminarily reviewed by Quality Assurance, and slight data changes may follow final review.
Results at a glance
Three SenePlex+ results worth knowing first.
SeneGenceReviewNormal-to-Dry Regimen Results
Normal-to-Dry Regimen: First-Use and 8-Week Results
Hydration increased 49.99% after the first use and remained 28.62% above baseline at Week 8. Visible radiance improved 23.60% at Week 8.
Immediate hydration49.99%
Measured after the first use
Week 8 hydration28.62%
Measured at Week 8
Week 8 expert-graded radiance23.60%
96.88% of participants improved
Week 8 R0 firmness6.59%
Measured at Week 8
What participants noticed at Week 8
100%said skin felt more moisturized.
100%said skin texture felt smoother.
100%said skin tone looked redefined and more supple.
96.88%said skin appeared more luminous, radiant, and bright.
What the eight-week study tested
The study tested 3 in 1 Cleanser, DayTime Moisturizer, and Evening Moisturizer together. The results apply to that three-product Normal-to-Dry regimen, not to one product alone.
SeneGenceReviewEvening Moisturizer Results
Evening Moisturizer Normal to Dry: 20-Day Surface-Renewal Results
In an independent 20-day study, Evening Moisturizer Normal to Dry with SenePlex+ showed up to 100% greater visible surface-cell turnover than untreated skin by Day 18.
Mean time to full visible surface turnover was 15.5 days at treated sites versus 18.0 days at untreated sites. By Day 18, the treated sites had reached complete visible clearance in the study measure.
15.5 vs 18.0
mean days to full visible surface turnover
Treated vs untreated
Evening Moisturizer Normal to Dry
0.00 vs 0.18
residual surface-stain intensity
Day 18 · treated vs untreated
Lower scores mean less residual surface stain.
33
participants completed
20-day study
Treated and untreated sites were compared on each participant.
Measured on the finished moisturizer
The study measured Evening Moisturizer Normal to Dry as a complete formula. It supports this moisturizer’s visible exfoliation result and should not be transferred to every SenePlex+ product.
SeneGenceReviewMethods and Sources
Study details and sources
The laboratory, products, timing, sample, measurements, and statistical detail for both studies.
Normal-to-Dry regimen laboratoryValidated Claim Support, LLC
Normal-to-Dry regimen products3 in 1 Cleanser; DayTime Moisturizer; Evening Moisturizer
Normal-to-Dry regimen design8-week single-arm regimen study; 34 enrolled / 32 completed
Evening Moisturizer laboratoryEssex Testing Clinic
Evening Moisturizer tested productEvening Moisturizer Normal to Dry
Evening Moisturizer study design20-day treated-site vs untreated-site comparison; 33 completed
Detailed regimen results
| Measured outcome | Immediate | Week 2 | Week 4 | Week 8 |
|---|---|---|---|---|
| Corneometer hydration | +49.99%; p<0.001 | +12.54%; p=0.005 | +11.98%; p=0.003 | +28.62%; p<0.001 |
| Cutometer R0 firmness | - | +7.06%; p=0.016 | - | +6.59%; p=0.033 |
| Expert-graded radiance | - | - | - | +23.60%; p<0.001 |
Hydration increase, firmer R0 readings and expert-graded radiance provide the central regimen results.
Participant experience
| Week 8 participant perception | Agreement |
|---|---|
| Skin feels more moisturized | 100% |
| Skin texture feels smoother | 100% |
| Skin tone looks redefined and more supple | 100% |
| Skin appears more luminous, radiant and bright | 96.88% |
Self-reported agreement, n=32.
Download the complete study reports
Original source pages follow.
Original reports and evidence records
The complete two-page Essex laboratory summary follows the regimen’s aggregate results.
Open the combined report package or inspect either study in its focused evidence record.
Download the combined clinical report (PDF) See the eight-week regimen evidence record See the 20-day surface-renewal evidence record Clinical resultsLaboratoryEssex Testing Clinic
Tested productEvening Moisturizer Normal to Dry
Study design20-day treated-site comparison
The complete PDF includes the Essex laboratory pages. One participant code was removed; aggregate findings are unchanged.