Is SeneGence clinically tested?

Quick answer

Yes. SeneGence tests its finished formulas in independent clinical studies, and the results are specific. In an independent study of 31 participants measured by image analysis, GLP Complex™ with SenePlex+® and Exosomes reduced the appearance of deep wrinkles by 11.2% at four weeks and 23.4% at eight weeks, and improved the look of facial volume by 8.4% at eight weeks. See the GLP Complex study. In an independent study of 31 women ages 38–75, measured with a skin-moisture meter against baseline, SeneCell™ improved skin hydration by a mean 73.9% immediately after application and 56.4% at eight weeks. See the SeneCell hydration study.

By SeneGence · Alan Kante, publisher · Updated October 30, 2026

4 min read

Normal-to-Dry regimen week-eight expert grading and consumer agreement on separate scales. — At eight weeks in the independent study of the Normal-to-Dry 3 in 1 Cleanser, DayTime Moisturizer and Evening Moisturizer used together, expert grading found improved brightness, radiance or luminosity in 96.88%, visible firmness in 80.65%, texture or smoothness in 71.88%, tone evenness in 56.25% and fine lines or wrinkles in 31.25% of subjects. In the same Normal-to-Dry regimen study’s week-eight consumer questionnaire (n=32), 100% agreed their skin felt more moisturized, skin tone looked more supple and texture felt smoother; 96.88% agreed skin looked more luminous, radiant or bright, and 96.88% said they would buy the regimen. Visible firmness was assessed in 31 participants; the other displayed expert-grading endpoints retain n=32.

Hydration gains with the three-product Normal-to-Dry regimen at four timepoints. — In an independent eight-week study of the Normal-to-Dry 3 in 1 Cleanser, DayTime Moisturizer and Evening Moisturizer used together, mean hydration measured by Corneometer improved 49.99% immediately, 12.5% at two weeks, 12.0% at four weeks and 28.62% at eight weeks versus baseline (34 women enrolled, 32 completed; n=32 immediately and at weeks two and four, n=31 at week eight).

Which clinical result answers your question?

One headline result per study, each with its own evidence.
Beauty priority	Tested product or regimen	Published finding	Read the evidence
Immediate hydration	SenePlex+® Normal-to-Dry regimen, with its cleanser and both moisturizers used together.	The tested SenePlex+ regimen improved measured hydration by 49.99% immediately after application.	Regimen methods and results
Hydration that lasts	SeneCell™ SenePlex+® StemCell Concentrate	In an independent eight-week study of 31 women ages 38–75, SeneCell™ SenePlex+® StemCell Concentrate improved measured skin hydration by a mean 32.5% at 48 hours, assessed by a skin-moisture meter compared with baseline.	SeneCell hydration study
Facial volume	GLP Complex™ with SenePlex+® and Exosomes	In an independent study, GLP Complex™ with SenePlex+® and Exosomes improved the look of facial volume by 8.4% at eight weeks.	GLP Complex results
A fresher-looking surface	Evening Moisturizer – Normal to Dry with SenePlex+®	In an independent 20-day study, Evening Moisturizer – Normal to Dry with SenePlex+® showed up to 100% greater visible surface-cell turnover than untreated skin by day 18.	Surface-turnover study
Crow’s feet	NeoTight® Rejuvenating Anti-Wrinkle Serum	After six weeks of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 24.53% average improvement in the appearance of crow’s feet.	NeoTight Rejuvenating results
Eye-area radiance	EyeCrème	After eight weeks with EyeCrème, 87.10% of participants showed measured improvement in skin radiance in the eye area.	EyeCrème eight-week results
Under-eye dark circles	NeoTight™ Eye Serum	In an independent study, NeoTight™ Eye Serum improved the appearance of under-eye dark circles by 38.10% at 6 weeks.	NeoTight Eye Serum six-week results

Every SeneGence product is rigorously tested for safety, quality and proven performance before it reaches your skin, and our skincare is dermatologist tested. Beauty Book 2026 (p. 8). See what independent testing means.

What did the SenePlex+ regimen study show?

One independent eight-week study followed the SenePlex+® Normal-to-Dry 3-in-1 Cleanser, DayTime Moisturizer and Evening Moisturizer used together. The SenePlex+® Normal-to-Dry skincare regimen increased hydration after the first use and, by Week 8, improved firmness, radiance, smoothness, tone evenness and line appearance. See the SenePlex+ regimen study.

How do I find the result for my product?

Start with the visible change you want, then read the result for that product in SeneGence Clinicals. SeneCell™ has its own measured hydration study, GLP Complex™ has product studies of deep-wrinkle and facial-volume appearance, and NeoTight® Rejuvenating Anti-Wrinkle Serum has studies of elasticity, lines, hydration and the experience of use. See the GLP Complex study and GLP Complex, see the SeneCell hydration study and SeneCell, or see the NeoTight elasticity study and NeoTight Rejuvenating Anti-Wrinkle Serum.

Does SeneGence skincare work?

Yes. In independent studies, SeneGence finished products and whole regimens measurably improved the look of skin: read the GLP Complex report and the SeneCell hydration report. In an independent eight-week study, the Normal-to-Dry 3 in 1 Cleanser, DayTime Moisturizer and Evening Moisturizer, used together as a regimen, improved measured hydration by 49.99% immediately after application. SenePlex+ Normal-to-Dry regimen — eight-week skin quality. In an independent eight-week study of 32 women using the SenePlex+® Normal-to-Dry regimen (3 in 1 Cleanser – Normal to Dry, DayTime Moisturizer – Normal to Dry and Evening Moisturizer – Normal to Dry), expert grading at week 8 found improved visible brightness, radiance, or luminosity in 96.88% of subjects. Normal-to-Dry regimen evidence and full report.

Study results at a glance

SenePlex+ Normal-to-Dry regimen — eight-week skin quality17 results

SenePlex+ Normal-to-Dry regimen — eight-week skin quality
Result	Kind of result	When it was measured
The tested SenePlex+ regimen improved measured hydration by 49.99% immediately after application.	Measured result	immediate
The tested SenePlex+ regimen improved measured hydration by 12.5% at week 2.	Measured result	2 weeks
The tested SenePlex+ regimen improved measured firmness by 7.06% at week 2 on the Cutometer R0 parameter, where a lower value indicates firmer skin.	Measured result	2 weeks
The tested SenePlex+ regimen improved measured hydration by 12.0% at week 4.	Measured result	4 weeks
The tested SenePlex+ regimen improved measured hydration by 28.62% at 8 weeks.	Measured result	8 weeks

Show 12 more results

SenePlex+ Normal-to-Dry regimen — eight-week skin quality, more results
Result	Kind of result	When it was measured
The tested SenePlex+ regimen improved measured firmness by 6.59% at week 8 on the Cutometer R0 parameter, where a lower value indicates firmer skin.	Measured result	8 weeks
In an independent eight-week study of 32 women using the SenePlex+® Normal-to-Dry regimen (3 in 1 Cleanser – Normal to Dry, DayTime Moisturizer – Normal to Dry and Evening Moisturizer – Normal to Dry), expert grading at week 8 found improved visible brightness, radiance, or luminosity in 96.88% of subjects.	Expert assessment	8 weeks
At week 8, expert grading found improved visible firmness in 80.65% of subjects using the tested regimen.	Expert assessment	8 weeks
At week 8, expert grading found improved visible texture or smoothness in 71.88% of subjects using the tested regimen.	Expert assessment	8 weeks
At week 8, expert grading found improved visible tone evenness in 56.25% of subjects using the tested regimen.	Expert assessment	8 weeks
At week 8, expert grading found improvement in the appearance of fine lines or wrinkles in 31.25% of subjects using the tested regimen.	Expert assessment	8 weeks
At week 8, 100% of subjects agreed that skin felt more moisturized.	Participant feedback	8 weeks
At week 8, 100% of subjects agreed that skin tone looked more supple.	Participant feedback	8 weeks
At week 8, 100% of subjects agreed that skin texture felt smoother.	Participant feedback	8 weeks
In an independent eight-week study of 32 women using the SenePlex+® Normal-to-Dry regimen (3 in 1 Cleanser – Normal to Dry, DayTime Moisturizer – Normal to Dry and Evening Moisturizer – Normal to Dry), 96.88% agreed at week 8 that their skin looked more luminous, radiant, or bright.	Participant feedback	8 weeks
At week eight, 96.88% of participants said they would buy the Normal-to-Dry 3-in-1 Cleanser, DayTime Moisturizer, and Evening Moisturizer regimen.	Participant feedback	8 weeks
At week 8, expert grading found a 23.60% mean improvement in visible radiance in the tested Normal-to-Dry three-product regimen.	Expert assessment	8 weeks

Who took part: 34 enrolled; 32 completed; women ages 25–70
How it was evaluated: Eight-week dermatologist-supervised monadic study; Corneometer and Cutometer measurements, expert grading, and consumer questionnaire
Statistical context: Hydration significant at every measured timepoint: p<0.001 immediately and at Week 8; p=0.005 at Week 2; p=0.003 at Week 4; expert-grading endpoints statistically significant as reported

See the full finding: SenePlex+ Normal-to-Dry regimen — eight-week skin quality · Open the study PDF

GLP Complex™ with SenePlex+® and Exosomes — wrinkles and facial-volume study5 results

GLP Complex™ with SenePlex+® and Exosomes — wrinkles and facial-volume study
Result	Kind of result	When it was measured
In an independent study of 31 participants measured by image analysis, GLP Complex™ with SenePlex+® and Exosomes reduced the appearance of deep wrinkles by 11.2% at four weeks.	Measured result	4 weeks
All 31 participants showed image-analyzed improvement in deep-wrinkle appearance after four and eight weeks of using GLP Complex™ with SenePlex+® and Exosomes.	Measured result	4 and 8 weeks
In an independent study, GLP Complex™ with SenePlex+® and Exosomes reduced the appearance of deep wrinkles by 23.4% at eight weeks.	Measured result	8 weeks
In an independent study, GLP Complex™ with SenePlex+® and Exosomes improved the look of facial volume by 8.4% at eight weeks.	Measured result	8 weeks
At eight weeks, 81% of participants showed image-analyzed improvement in the look of facial volume after using GLP Complex™ with SenePlex+® and Exosomes.	Measured result	8 weeks

Who took part: 31 participants
How it was evaluated: Image analysis of the finished GLP Complex formula
Statistical context: Deep-wrinkle endpoints p<0.001; facial-volume endpoint at eight weeks p=0.044

See the full finding: GLP Complex™ with SenePlex+® and Exosomes — wrinkles and facial-volume study · Open the study PDF

SeneCell™ SenePlex+® StemCell Concentrate — hydration study11 results

SeneCell™ SenePlex+® StemCell Concentrate — hydration study
Result	Kind of result	When it was measured
In an independent eight-week study of 31 women ages 38–75, SeneCell™ SenePlex+® StemCell Concentrate improved measured skin hydration by a mean 73.9% immediately after application, assessed by a skin-moisture meter compared with baseline.	Measured result	immediate
All 31 participants showed measured improvement in skin hydration immediately after applying SeneCell.	Measured result	immediate
In an independent eight-week study of 31 women ages 38–75, SeneCell™ SenePlex+® StemCell Concentrate improved measured skin hydration by a mean 42.5% at 24 hours, assessed by a skin-moisture meter compared with baseline.	Measured result	24 hours
At 24 hours, 81% of participants showed measured improvement in skin hydration after using SeneCell.	Measured result	24 hours
In an independent eight-week study of 31 women ages 38–75, SeneCell™ SenePlex+® StemCell Concentrate improved measured skin hydration by a mean 32.5% at 48 hours, assessed by a skin-moisture meter compared with baseline.	Measured result	48 hours

Show 6 more results

SeneCell™ SenePlex+® StemCell Concentrate — hydration study, more results
Result	Kind of result	When it was measured
At 48 hours, 81% of participants showed measured improvement in skin hydration after using SeneCell.	Measured result	48 hours
In an independent eight-week study of 31 women ages 38–75, SeneCell™ SenePlex+® StemCell Concentrate improved measured skin hydration by a mean 22.1% at four weeks, assessed by a skin-moisture meter compared with baseline.	Measured result	4 weeks
At 4 weeks, 74% of participants showed measured improvement in skin hydration after using SeneCell.	Measured result	4 weeks
In an independent eight-week study of 31 women ages 38–75, SeneCell™ SenePlex+® StemCell Concentrate improved measured skin hydration by a mean 56.4% at eight weeks, assessed by a skin-moisture meter compared with baseline.	Measured result	8 weeks
All 31 participants showed measured improvement in skin hydration after 8 weeks of using SeneCell.	Measured result	8 weeks
No irritation was observed among the 31 participants during the eight-week SeneCell study.	Safety testing	8-week study

Who took part: 31 women, ages 38–75
How it was evaluated: Corneometer hydration measurement
Statistical context: Every reported hydration timepoint p<0.001; no irritation observed

See the full finding: SeneCell™ SenePlex+® StemCell Concentrate — hydration study · Open the study PDF

SenePlex+ Evening Moisturizer Normal to Dry — surface-renewal study8 results

SenePlex+ Evening Moisturizer Normal to Dry — surface-renewal study
Result	Kind of result	When it was measured
In a 20-day independent clinical study of 33 women ages 19–65, measured by expert clinical grading compared with baseline, Evening Moisturizer – Normal to Dry with SenePlex+® and orchid stem cells achieved 100% cell renewal in 18 days, against a typical skin-renewal cycle of 28 or more days.	Measured result	18 days; 20-day study
In a 20-day independent clinical study of 33 women ages 19–65, measured by expert clinical grading compared with baseline, Evening Moisturizer – Normal to Dry with SenePlex+® and orchid stem cells accelerated skin cell renewal by 35.7%.	Measured result	20-day study
The treated SenePlex+ formula site showed 49% greater visible surface-cell turnover than the untreated control site at day 13.	Measured result	20-day study; day-13 endpoint
The treated SenePlex+ formula site showed 80% greater visible surface-cell turnover than the untreated control site at day 16.	Measured result	20-day study; day-16 endpoint
The treated SenePlex+ formula site showed 94% greater visible surface-cell turnover than the untreated control site at day 17.	Measured result	20-day study; day-17 endpoint

Show 3 more results

SenePlex+ Evening Moisturizer Normal to Dry — surface-renewal study, more results
Result	Kind of result	When it was measured
In an independent 20-day study, Evening Moisturizer – Normal to Dry with SenePlex+® showed up to 100% greater visible surface-cell turnover than untreated skin by day 18.	Measured result	20-day study; day-18 endpoint
In the independent 20-day study of Evening Moisturizer – Normal to Dry with SenePlex+® in 33 women ages 19–65, assessed by dansyl-chloride scoring, mean time to full visible surface turnover was 15.5 ± 0.4 days at the treated site versus 18.0 ± 0.4 days at the untreated control site.	Measured result	20-day study
At day 18, mean residual surface-stain intensity was 0.00 at the treated site versus 0.18 at the untreated control site; lower values indicate faster clearance.	Measured result	20-day study; day-18 endpoint

Who took part: 34 enrolled; 33 completed
How it was evaluated: Dansyl-chloride visual scoring of treated and untreated sites on the same subjects
Statistical context: Significant versus control on days 2–18; headline and mean-time comparisons p<0.001

See the full finding: SenePlex+ Evening Moisturizer Normal to Dry — surface-renewal study · Open the study PDF

NeoTight® Rejuvenating Anti-Wrinkle Serum — one-hour and six-week study20 results

NeoTight® Rejuvenating Anti-Wrinkle Serum — one-hour and six-week study
Result	Kind of result	When it was measured
In an independent study, Rejuvenating Anti-Wrinkle Serum improved measured net skin elasticity by 7.65% one hour after a single application.	Measured result	baseline to 1 hour after a single application
One hour after a single application of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 12.05% average improvement in firmer-looking skin.	Expert assessment	1 hour after a single application
At week 6, 84.38% of participants agreed that they liked how their skin felt immediately after applying Rejuvenating Anti-Wrinkle Serum.	Participant feedback	week-6 questionnaire about immediate application feel
After six weeks of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 24.53% average improvement in the appearance of crow’s feet.	Expert assessment	6 weeks
After six weeks of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 13.64% average improvement in the appearance of upper-lip lines.	Expert assessment	6 weeks

Show 15 more results

NeoTight® Rejuvenating Anti-Wrinkle Serum — one-hour and six-week study, more results
Result	Kind of result	When it was measured
After six weeks of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 7.14% average improvement in the appearance of nasolabial folds.	Expert assessment	6 weeks
At week 6, 96.88% of participants agreed that Rejuvenating Anti-Wrinkle Serum hydrated their skin well.	Participant feedback	6 weeks
At week 6, 87.50% of participants agreed that Rejuvenating Anti-Wrinkle Serum improved their skin's overall appearance.	Participant feedback	6 weeks
At week 6, 84.38% of participants agreed that NeoTight® Rejuvenating Anti-Wrinkle Serum reduced the appearance of fine lines and wrinkles.	Participant feedback	6 weeks
At week 6, 78.13% of participants agreed that NeoTight® Rejuvenating Anti-Wrinkle Serum reduced the appearance of crow's feet around the eyes.	Participant feedback	6 weeks
At week 6, 62.50% of participants agreed that NeoTight® Rejuvenating Anti-Wrinkle Serum reduced the appearance of nasolabial folds.	Participant feedback	6 weeks
At week 6, 71.88% of participants agreed that NeoTight® Rejuvenating Anti-Wrinkle Serum reduced the appearance of upper-lip lines.	Participant feedback	6 weeks
At week 6, 75.00% of participants agreed that their face appeared more youthful after using Rejuvenating Anti-Wrinkle Serum.	Participant feedback	6 weeks
At week 6, 75.00% of participants agreed that their skin felt firmer after using Rejuvenating Anti-Wrinkle Serum.	Participant feedback	6 weeks
At week 6, 71.88% of participants agreed that their skin appeared tighter after using Rejuvenating Anti-Wrinkle Serum.	Participant feedback	6 weeks
At week 6, 96.88% of participants agreed that their skin tolerated Rejuvenating Anti-Wrinkle Serum well without sensitivities.	Participant feedback	6 weeks
At week 6, 84.38% of participants agreed that they liked the color, texture, smell, and feel of Rejuvenating Anti-Wrinkle Serum.	Participant feedback	6 weeks
At week 6, 71.88% of participants agreed that Rejuvenating Anti-Wrinkle Serum absorbed well and did not feel greasy or tacky.	Participant feedback	6 weeks
At week 6, 87.50% of participants agreed that they liked Rejuvenating Anti-Wrinkle Serum overall.	Participant feedback	6 weeks
At week 6, 71.88% of participants agreed that they noticed a firmer-looking, more lifted appearance after applying Rejuvenating Anti-Wrinkle Serum.	Participant feedback	week-6 questionnaire about appearance after application

Who took part: n=32 for Cutometer and participant questionnaire; n=31 for expert grading
How it was evaluated: Cutometer MPA 580 R5, expert grading, and participant questionnaire; each endpoint remains separately labeled
Statistical context: Baseline-to-1-hour Cutometer R5 change p=0.015; expert-grading and participant-agreement results are descriptive as reported

See the full finding: NeoTight® Rejuvenating Anti-Wrinkle Serum — one-hour and six-week study · Open the study PDF

EyeCrème — eight-week clinical, consumer, and safety results9 results

EyeCrème — eight-week clinical, consumer, and safety results
Result	Kind of result	When it was measured
In the separate eight-week consumer study of EyeCrème, 67.74% of participants agreed that the skin around their eyes immediately felt hydrated, and 64.52% agreed that their crow’s feet looked reduced.	Participant feedback	eight-week consumer study; immediate-feel and crow's-feet statements
After eight weeks with EyeCrème, 87.10% of participants showed measured improvement in skin radiance in the eye area.	Measured result	8 weeks
After eight weeks with EyeCrème, 64.52% of participants showed a measured decrease in the appearance of wrinkles in the eye area.	Measured result	8 weeks
At week 8 of the separate EyeCrème consumer study of 31 participants, 83.87% agreed that their lines and wrinkles appear diminished.	Participant feedback	8 weeks
After eight weeks with EyeCrème, 80.65% of consumer-study participants agreed that their eye area looked more rested.	Participant feedback	8 weeks

Show 4 more results

EyeCrème — eight-week clinical, consumer, and safety results, more results
Result	Kind of result	When it was measured
After eight weeks with EyeCrème, 77.42% of consumer-study participants agreed that their eye area looked smoother and more awake.	Participant feedback	8 weeks
After eight weeks with EyeCrème, 74.19% of consumer-study participants agreed that their eye area looked more radiant.	Participant feedback	8 weeks
After eight weeks with EyeCrème, 70.97% of consumer-study participants agreed that their eye area looked refreshed and less crepey.	Participant feedback	8 weeks
EyeCrème is ophthalmologist-tested and safe for contact-lens wearers.	Safety testing	during daily EyeCrème use

Who took part: 31 participants in the clinical study; 31 participants in the separate consumer study
How it was evaluated: Expert grading and Visioscan analysis compared with baseline; consumer agreement reported separately

See the full finding: EyeCrème — eight-week clinical, consumer, and safety results · Open the study PDF

NeoTight™ Eye Serum — six-week study3 results

NeoTight™ Eye Serum — six-week study
Result	Kind of result	When it was measured
In an independent study, NeoTight™ Eye Serum improved the appearance of under-eye dark circles by 38.10% at 6 weeks.	Expert assessment	6 weeks
In an independent study, NeoTight™ Eye Serum improved the appearance of under-eye puffiness or bags by 23.12% at 6 weeks.	Expert assessment	6 weeks
In an independent study, NeoTight™ Eye Serum improved the appearance of peri-orbital fine lines and wrinkles by 8.82% at 6 weeks.	Expert assessment	6 weeks

Who took part: 33 completed; endpoint-specific n=31–33
How it was evaluated: Expert clinical grading and Cutometer measurement
Statistical context: Registered expert-grading endpoints p<0.001

See the full finding: NeoTight™ Eye Serum — six-week study · Open the study PDF