Clinical Results

Moisture from the first use, and the light comes back over the weeks that follow. At Week 8, expert grading of the three-product Normal-to-Dry regimen measured a 23.60% mean improvement in visible radiance. Firmness, smoothness, tone evenness, and the appearance of fine lines improved too. An immediate moisture benefit, and firmer, smoother, more radiant-looking skin eight weeks in.

A fresher, smoother-looking surface, sooner. In an independent 20-day study, Evening Moisturizer – Normal to Dry with SenePlex+® showed up to 100% greater visible surface-cell turnover than untreated skin by day 18.

Lightweight hydration goes on, and skin keeps hold of it. In an independent study, SeneCell™ SenePlex+® StemCell Concentrate improved measured skin hydration by 32.5% at 48 hours and by 56.4% at eight weeks. Moisture that outlasts the day you put it on.

Deep lines soften first; visibly restored facial volume follows. In an independent study, GLP Complex™ with SenePlex+® and Exosomes reduced the appearance of deep wrinkles by 11.2% at four weeks and 23.4% at eight weeks, and improved the look of facial volume by 8.4% at eight weeks. Choose it when smoother-looking deep wrinkles and the look of facial volume are both the goal.

One application, and the change is already measurable. In an independent study, NeoTight® Rejuvenating Anti-Wrinkle Serum improved measured net skin elasticity by 7.65% one hour after a single application, when experts also graded skin firmer-looking; after six weeks, expression lines looked improved and 75% of participants said their skin felt firmer. An immediate result that keeps building.

Brighter, more even-looking skin, with less to cover. Over eight weeks, image analysis measured progressive gains in brightness, hyperpigmentation, dark-mark appearance, and skin tone, and 88% of participants improved on the brightness endpoint by week 8. When the spots are the thing you want gone, this is the one.

Daily moisture for the thinnest skin on your face, and a more rested-looking eye area. In an eight-week independent clinical study of EyeCrème, 87.10% of participants showed measured improvement in eye-area skin radiance and 64.52% showed a measured decrease in eye-area wrinkle appearance.

At four hours, mean LipSense® Cream (formerly HydraMatte) appearance scores were 3.2 by trained-technician assessment and 3.4 by participant assessment on the study's 0-to-4 scale. Both scores sit inside the study's good-appearance band, with low measured transfer and appearance preserved after brief water exposure. Current product directions separately call for one layer, about a minute to dry, with no Gloss required.

Calanthe discolor orchid stem cells and extracts, one of the two orchids in SenePlex+®, are chosen for lifting care. The ingredient maker reports a 7.6% eyelid-lift appearance result after 56 days with its Calanthe Discolor-derived material, in a study of 26 women aged 40–65. The material’s eyelid and jawline effects were assessed in two in-vivo studies in women, run separately from SeneGence’s own clinical studies. Because the orchid stem cells are part of SenePlex+®, you'll find them in many SenePlex+® formulas, among them SeneCell™ SenePlex+® StemCell Concentrate and, for the eye area, both NeoTight™ Eye Serum and EyeCrème.

SeneGence uses this plant-sugar complex, Xylitylglucoside, Anhydroxylitol and Xylitol, in Climate Control, the water-light gel essence that prepares skin before treatment. In the ingredient maker’s hand study, 20 volunteers used a 72% v/v alcohol gel containing 1.5% Xylitylglucoside, Anhydroxylitol, and Xylitol at least five times daily, and corneometry measured hydration 13.5% higher at 24 hours than the initial measurement. Separate cell assays reported 24% higher hyaluronic-acid production in keratinocytes at 0.01% complex and 20% higher production in fibroblasts at 0.1% complex. The percentages belong to the ingredient maker’s hand-gel and cell studies, not to the finished essence.