What is SeneCell and what does it do?
Quick answer
Choose SeneCell™ SenePlex+® StemCell Concentrate, our anti-aging serum with orchid stem cells, peptides, hyaluronic acid and our highest dose of SenePlex+®, to deliver instant and lasting hydration, visibly lift and firm skin, and help reduce fine lines and wrinkles. In an independent eight-week study, its hydration was measured from the first application onward. Hydration increased by a mean 73.9% immediately, remained 42.5% higher at 24 hours and 32.5% higher at 48 hours, and reached 56.4% at eight weeks. See the SeneCell hydration study. All 31 participants showed measured improvement in skin hydration after 8 weeks of using SeneCell.
By SeneGence · 
Alan Kante, publisher · Updated
- 2 min read
- SenePlex+®
- Peptides
SenePlex+® is one of SeneCell’s five clinical-level actives. SenePlex+® accelerated skin cell renewal by 100% in 18 days at clinical levels in a 20-day independent clinical study of 33 women ages 19–65, measured by expert clinical grading compared with baseline. Beauty Book 2026 (p. 15).
What did the SeneCell study show?
All 31 participants showed measured improvement in skin hydration immediately after applying SeneCell. Read every timepoint. SenePlex+® was also tested across a whole routine. In an independent eight-week study, the Normal-to-Dry 3 in 1 Cleanser, DayTime Moisturizer and Evening Moisturizer, used together as a regimen, improved measured hydration by 49.99% immediately after application. See the regimen study or its findings.
What is inside SeneCell?
For a supple, resilient-looking finish, Calanthe Discolor (Ebine) Extract, the orchid stem cells, helps skin look lifted and less saggy, and Caprooyl Tetrapeptide-3 helps firm and smooth the look of fine lines. For its instant, lasting hydration, Chondrus Crispus (Carrageenan) Extract, a red-algae extract, works with Sodium Hyaluronate Crosspolymer and Sodium Hyaluronate (a form of hyaluronic acid), and SenePlex+® completes the formula. The orchid engraved on the bottle is the orchid of the legend that inspired SenePlex+®; follow the Vanuatu story.
How do I use SeneCell?
Smooth two pumps over clean face and neck, morning and night, before moisturizer; in the Triple Cell Renewal Trio it is the final treatment, after GLP Complex™. SeneCell.
Can I mix SeneCell into moisturizer or foundation?
Lightweight and layerable, SeneCell can be worn alone or mixed into moisturizer or foundation for a luminous finish. Mix it into one product at a time. Official SeneCell formula and use.
What do the orchid stem cell secretomes do?
An advanced anti-aging serum with 5 clinical-level actives, including plant-derived stem cell secretomes, growth factors & targeted peptides, to double skin cell renewal, visibly lift & firm skin, & support lasting hydration. Beauty Book 2026 (p. 15).
Calanthe discolor orchid stem cells supply the secretomes. Secretomes help visibly lift & improve the appearance of sagging, drooping skin Beauty Book 2026 (p. 15).
Benefits, formula & use
SeneCell™ SenePlex+® StemCell Concentrate
- Application
- Apply 2 pumps of SeneCell™ SenePlex+® StemCell Concentrate to clean face and neck, morning and night as your first skincare step after cleansing or exfoliating.
- Good For
- SeneCell™ SenePlex+® StemCell Concentrate suits all skin types, especially dry with fine lines, sagging, & dullness.
SeneGence Beauty Book 2026, p. 15 · Current formula and directions: official SeneGence product page · View SeneCell™ SenePlex+® StemCell Concentrate on SeneGence
Study results at a glance
SeneCell™ SenePlex+® StemCell Concentrate — hydration study11 results
| Result | Kind of result | When it was measured |
|---|---|---|
| In an independent eight-week study of 31 women ages 38–75, SeneCell™ SenePlex+® StemCell Concentrate improved measured skin hydration by a mean 73.9% immediately after application, assessed by a skin-moisture meter compared with baseline. | Measured result | immediate |
| All 31 participants showed measured improvement in skin hydration immediately after applying SeneCell. | Measured result | immediate |
| In an independent eight-week study of 31 women ages 38–75, SeneCell™ SenePlex+® StemCell Concentrate improved measured skin hydration by a mean 42.5% at 24 hours, assessed by a skin-moisture meter compared with baseline. | Measured result | 24 hours |
| At 24 hours, 81% of participants showed measured improvement in skin hydration after using SeneCell. | Measured result | 24 hours |
| In an independent eight-week study of 31 women ages 38–75, SeneCell™ SenePlex+® StemCell Concentrate improved measured skin hydration by a mean 32.5% at 48 hours, assessed by a skin-moisture meter compared with baseline. | Measured result | 48 hours |
Show 6 more results
| Result | Kind of result | When it was measured |
|---|---|---|
| At 48 hours, 81% of participants showed measured improvement in skin hydration after using SeneCell. | Measured result | 48 hours |
| In an independent eight-week study of 31 women ages 38–75, SeneCell™ SenePlex+® StemCell Concentrate improved measured skin hydration by a mean 22.1% at four weeks, assessed by a skin-moisture meter compared with baseline. | Measured result | 4 weeks |
| At 4 weeks, 74% of participants showed measured improvement in skin hydration after using SeneCell. | Measured result | 4 weeks |
| In an independent eight-week study of 31 women ages 38–75, SeneCell™ SenePlex+® StemCell Concentrate improved measured skin hydration by a mean 56.4% at eight weeks, assessed by a skin-moisture meter compared with baseline. | Measured result | 8 weeks |
| All 31 participants showed measured improvement in skin hydration after 8 weeks of using SeneCell. | Measured result | 8 weeks |
| No irritation was observed among the 31 participants during the eight-week SeneCell study. | Safety testing | 8-week study |
See the full finding: SeneCell™ SenePlex+® StemCell Concentrate — hydration study · Open the study PDF
SenePlex+ Normal-to-Dry regimen — eight-week skin quality17 results
| Result | Kind of result | When it was measured |
|---|---|---|
| The tested SenePlex+ regimen improved measured hydration by 49.99% immediately after application. | Measured result | immediate |
| The tested SenePlex+ regimen improved measured hydration by 12.5% at week 2. | Measured result | 2 weeks |
| The tested SenePlex+ regimen improved measured firmness by 7.06% at week 2 on the Cutometer R0 parameter, where a lower value indicates firmer skin. | Measured result | 2 weeks |
| The tested SenePlex+ regimen improved measured hydration by 12.0% at week 4. | Measured result | 4 weeks |
| The tested SenePlex+ regimen improved measured hydration by 28.62% at 8 weeks. | Measured result | 8 weeks |
Show 12 more results
| Result | Kind of result | When it was measured |
|---|---|---|
| The tested SenePlex+ regimen improved measured firmness by 6.59% at week 8 on the Cutometer R0 parameter, where a lower value indicates firmer skin. | Measured result | 8 weeks |
| In an independent eight-week study of 32 women using the SenePlex+® Normal-to-Dry regimen (3 in 1 Cleanser – Normal to Dry, DayTime Moisturizer – Normal to Dry and Evening Moisturizer – Normal to Dry), expert grading at week 8 found improved visible brightness, radiance, or luminosity in 96.88% of subjects. | Expert assessment | 8 weeks |
| At week 8, expert grading found improved visible firmness in 80.65% of subjects using the tested regimen. | Expert assessment | 8 weeks |
| At week 8, expert grading found improved visible texture or smoothness in 71.88% of subjects using the tested regimen. | Expert assessment | 8 weeks |
| At week 8, expert grading found improved visible tone evenness in 56.25% of subjects using the tested regimen. | Expert assessment | 8 weeks |
| At week 8, expert grading found improvement in the appearance of fine lines or wrinkles in 31.25% of subjects using the tested regimen. | Expert assessment | 8 weeks |
| At week 8, 100% of subjects agreed that skin felt more moisturized. | Participant feedback | 8 weeks |
| At week 8, 100% of subjects agreed that skin tone looked more supple. | Participant feedback | 8 weeks |
| At week 8, 100% of subjects agreed that skin texture felt smoother. | Participant feedback | 8 weeks |
| In an independent eight-week study of 32 women using the SenePlex+® Normal-to-Dry regimen (3 in 1 Cleanser – Normal to Dry, DayTime Moisturizer – Normal to Dry and Evening Moisturizer – Normal to Dry), 96.88% agreed at week 8 that their skin looked more luminous, radiant, or bright. | Participant feedback | 8 weeks |
| At week eight, 96.88% of participants said they would buy the Normal-to-Dry 3-in-1 Cleanser, DayTime Moisturizer, and Evening Moisturizer regimen. | Participant feedback | 8 weeks |
| At week 8, expert grading found a 23.60% mean improvement in visible radiance in the tested Normal-to-Dry three-product regimen. | Expert assessment | 8 weeks |
See the full finding: SenePlex+ Normal-to-Dry regimen — eight-week skin quality · Open the study PDF
Full ingredient list
SeneCell™ SenePlex+® StemCell ConcentrateIngredient guide
Aqua/Water/Eau, Glycerin, Sodium Polyacrylate, Lecithin, Chondrus Crispus (Carrageenan) Extract, Lauroyl Lysine, Potassium Sorbate, Parfum/Fragrance, Sodium Hyaluronate Crosspolymer, Citric Acid, Ethylhexylglycerin, Benzyl Benzoate, Aloe Barbadensis (Aloe Vera) Leaf Juice, Trisodium Ethylenediamine Disuccinate, Gluconolactone, Hexamethylindanopyran, Linalool, Sodium Benzoate, Hydroxycitronellal, Geraniol, Sodium Hyaluronate, Citronellol, Alpha-Isomethyl Ionone, Caprooyl Tetrapeptide-3, Dextran, Tocopheryl Acetate, Panthenol, Butylene Glycol, Calanthe Discolor (Ebine) Extract, Hydrolyzed Opuntia Ficus-Indica (Prickly Pear) Flower Extract, Xanthan Gum, 1, 2-Hexanediol, Caprylyl Glycol, Calcium Gluconate, Laminaria Digitata (Kelp) Extract, Saccharomyces Cerevisiae (Yeast) Extract, Orchis Mascula (Orchid) Flower Extract, Phenoxyethanol, Urea*, Glucosamine HCl. Synthetic*
Official product reference checked September 18, 2026. View SeneCell™ SenePlex+® StemCell Concentrate on SeneGence