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Choosing products

Which SeneGence skincare should I buy first?

Quick answer

Start with the SeneGence Core 4 for your skin type: a cleanser, a daytime moisturizer, an evening moisturizer and EyeCrème, in Dry, Normal to Dry or Normal to Oily, or the Microbiome Collection for oily-to-sensitive skin. It is the daily base every treatment builds on, and it is tested. In an independent eight-week study, the Normal-to-Dry 3 in 1 Cleanser, DayTime Moisturizer and Evening Moisturizer, used together as a regimen, improved measured hydration by 49.99% immediately after application. See the regimen study.

By SeneGence · Alan Kante, publisher · Updated

The Core 4 in the Normal to Oily formulas: 3 in 1 Cleanser, DayTime Moisturizer and Evening Moisturizer on white marble, with an open jar of EyeCrème beside them.
The Core 4, shown in the Normal to Oily formulas: cleanse, DayTime and Evening Moisturizer, plus EyeCrème.
Hydration gains with the three-product Normal-to-Dry regimen at four timepoints.
In an independent eight-week study of the Normal-to-Dry 3 in 1 Cleanser, DayTime Moisturizer and Evening Moisturizer used together, mean hydration measured by Corneometer improved 49.99% immediately, 12.5% at two weeks, 12.0% at four weeks and 28.62% at eight weeks versus baseline (34 women enrolled, 32 completed; n=32 immediately and at weeks two and four, n=31 at week eight).

How do the four Core 4 routines compare?

Each Core 4 is a cleanser, DayTime Moisturizer, Evening Moisturizer and EyeCrème for one skin type.
Your skinChooseWhat it does for youExplore
DryThe Dry Core 4Choose Dry for lipid replenishment and a lasting hydration cascade when skin needs help holding moisture.Dry SkinCare Regimen Set · Beauty Book 2026
Normal to dryThe Normal to Dry Core 4Choose Normal to Dry for balanced hydration through seasonal changes, with multi-weight moisture support for smooth, resilient-looking skin.Normal-Dry SkinCare Regimen Set · Beauty Book 2026
Normal to oilyThe Normal to Oily Core 4Choose Normal to Oily for lightweight, peptide-infused hydration and oil balance without clogging pores.Normal-Oily SkinCare Regimen Set · Beauty Book 2026
Oily to sensitiveThe Microbiome Collection, with Microbiome Correcting Cleanser in the cleanser’s placeChoose the Oily to Sensitive Microbiome Collection for microbiome-first care that helps calm sensitivity, fight blemishes and strengthen the barrier, and a daytime moisturizer with broad-spectrum SPF 15.Microbiome SkinCare Regimen Set · Beauty Book 2026

The 3-in-1 Cleanser, DayTime Moisturizer, Evening Moisturizer, and EyeCrème form the Core 4. In the Microbiome Collection, Microbiome Correcting Cleanser takes the cleanser’s place. Use DayTime Moisturizer in the morning and Evening Moisturizer at night; that simple rhythm makes it easier to judge fit. EyeCrème, the fourth step, has its own study. After eight weeks with EyeCrème, 87.10% of participants showed measured improvement in skin radiance in the eye area. See the EyeCrème results or the regimen’s hydration findings.

Which Core 4 fits your skin?

The Beauty Book 2026 (pp. 10–13) matches each Core 4 to the skin it suits.

The Core 4 cleanser, daytime and evening moisturizers and EyeCrème, followed by targeted care.
Start with the Core 4 for your skin type: 3 in 1 Cleanser, DayTime Moisturizer, Evening Moisturizer and EyeCrème, then add a targeted serum. In an independent eight-week clinical study of EyeCrème, 87.10% of participants showed improvement in eye-area radiance and 64.52% showed improvement in eye-area wrinkle appearance (n=31, expert grading versus baseline). In an independent eight-week clinical study of 31 participants using EyeCrème, 87.10% showed measured improvement in eye-area skin radiance and 64.52% showed a measured decrease in eye-area wrinkle appearance, assessed by expert grading and Visioscan analysis compared with baseline.
  • Dry skin needs help to add and retain the moisture it can’t hold onto. Choose Dry for lipid replenishment and a lasting hydration cascade when skin needs help holding moisture. Explore the Dry routine.
  • Normal-to-dry skin needs hydration normalized and balanced through every season. Choose Normal to Dry for balanced hydration through seasonal changes, with multi-weight moisture support for smooth, resilient-looking skin. Compare the Normal-to-Dry moisturizers.
  • Normal-to-oily skin wants hydration without heaviness. Choose Normal to Oily for lightweight, peptide-infused hydration and oil balance without clogging pores. Explore the Normal-to-Oily routine.
  • Oily or sensitive skin needs its barrier balanced and protected. Choose the Oily to Sensitive Microbiome Collection for microbiome-first care that helps calm sensitivity, fight blemishes and strengthen the barrier, and a daytime moisturizer with broad-spectrum SPF 15. Explore the Microbiome Collection.

Not sure of your skin type? See which SeneGence skincare is right for your skin type.

When skin feels dry, tight or depleted, make Nangai Oil the lipid-optimization step after treatment and before moisturizer. Use three to five drops of Nangai Oil after treatments and before DayTime or Evening Moisturizer. See the Nangai Oil record. Once the Core 4 feels right, add one treatment for the visible concern that matters most, such as the Triple Cell Renewal Trio. Shop the Dry SkinCare Regimen Set, Normal-Dry SkinCare Regimen Set, Normal-Oily SkinCare Regimen Set, or Microbiome SkinCare Regimen Set, or shop the Triple Cell Renewal Trio.

Study results at a glance

SenePlex+ Normal-to-Dry regimen — eight-week skin quality17 results
SenePlex+ Normal-to-Dry regimen — eight-week skin quality
ResultKind of resultWhen it was measured
The tested SenePlex+ regimen improved measured hydration by 49.99% immediately after application.Measured resultimmediate
The tested SenePlex+ regimen improved measured hydration by 12.5% at week 2.Measured result2 weeks
The tested SenePlex+ regimen improved measured firmness by 7.06% at week 2 on the Cutometer R0 parameter, where a lower value indicates firmer skin.Measured result2 weeks
The tested SenePlex+ regimen improved measured hydration by 12.0% at week 4.Measured result4 weeks
The tested SenePlex+ regimen improved measured hydration by 28.62% at 8 weeks.Measured result8 weeks
Show 12 more results
SenePlex+ Normal-to-Dry regimen — eight-week skin quality, more results
ResultKind of resultWhen it was measured
The tested SenePlex+ regimen improved measured firmness by 6.59% at week 8 on the Cutometer R0 parameter, where a lower value indicates firmer skin.Measured result8 weeks
In an independent eight-week study of 32 women using the SenePlex+® Normal-to-Dry regimen (3 in 1 Cleanser – Normal to Dry, DayTime Moisturizer – Normal to Dry and Evening Moisturizer – Normal to Dry), expert grading at week 8 found improved visible brightness, radiance, or luminosity in 96.88% of subjects.Expert assessment8 weeks
At week 8, expert grading found improved visible firmness in 80.65% of subjects using the tested regimen.Expert assessment8 weeks
At week 8, expert grading found improved visible texture or smoothness in 71.88% of subjects using the tested regimen.Expert assessment8 weeks
At week 8, expert grading found improved visible tone evenness in 56.25% of subjects using the tested regimen.Expert assessment8 weeks
At week 8, expert grading found improvement in the appearance of fine lines or wrinkles in 31.25% of subjects using the tested regimen.Expert assessment8 weeks
At week 8, 100% of subjects agreed that skin felt more moisturized.Participant feedback8 weeks
At week 8, 100% of subjects agreed that skin tone looked more supple.Participant feedback8 weeks
At week 8, 100% of subjects agreed that skin texture felt smoother.Participant feedback8 weeks
In an independent eight-week study of 32 women using the SenePlex+® Normal-to-Dry regimen (3 in 1 Cleanser – Normal to Dry, DayTime Moisturizer – Normal to Dry and Evening Moisturizer – Normal to Dry), 96.88% agreed at week 8 that their skin looked more luminous, radiant, or bright.Participant feedback8 weeks
At week eight, 96.88% of participants said they would buy the Normal-to-Dry 3-in-1 Cleanser, DayTime Moisturizer, and Evening Moisturizer regimen.Participant feedback8 weeks
At week 8, expert grading found a 23.60% mean improvement in visible radiance in the tested Normal-to-Dry three-product regimen.Expert assessment8 weeks
Who took part
34 enrolled; 32 completed; women ages 25–70
How it was evaluated
Eight-week dermatologist-supervised monadic study; Corneometer and Cutometer measurements, expert grading, and consumer questionnaire
Statistical context
Hydration significant at every measured timepoint: p<0.001 immediately and at Week 8; p=0.005 at Week 2; p=0.003 at Week 4; expert-grading endpoints statistically significant as reported

See the full finding: SenePlex+ Normal-to-Dry regimen — eight-week skin quality · Open the study PDF

EyeCrème — eight-week clinical, consumer, and safety results9 results
EyeCrème — eight-week clinical, consumer, and safety results
ResultKind of resultWhen it was measured
In the separate eight-week consumer study of EyeCrème, 67.74% of participants agreed that the skin around their eyes immediately felt hydrated, and 64.52% agreed that their crow’s feet looked reduced.Participant feedbackeight-week consumer study; immediate-feel and crow's-feet statements
After eight weeks with EyeCrème, 87.10% of participants showed measured improvement in skin radiance in the eye area.Measured result8 weeks
After eight weeks with EyeCrème, 64.52% of participants showed a measured decrease in the appearance of wrinkles in the eye area.Measured result8 weeks
At week 8 of the separate EyeCrème consumer study of 31 participants, 83.87% agreed that their lines and wrinkles appear diminished.Participant feedback8 weeks
After eight weeks with EyeCrème, 80.65% of consumer-study participants agreed that their eye area looked more rested.Participant feedback8 weeks
Show 4 more results
EyeCrème — eight-week clinical, consumer, and safety results, more results
ResultKind of resultWhen it was measured
After eight weeks with EyeCrème, 77.42% of consumer-study participants agreed that their eye area looked smoother and more awake.Participant feedback8 weeks
After eight weeks with EyeCrème, 74.19% of consumer-study participants agreed that their eye area looked more radiant.Participant feedback8 weeks
After eight weeks with EyeCrème, 70.97% of consumer-study participants agreed that their eye area looked refreshed and less crepey.Participant feedback8 weeks
EyeCrème is ophthalmologist-tested and safe for contact-lens wearers.Safety testingduring daily EyeCrème use
Who took part
31 participants in the clinical study; 31 participants in the separate consumer study
How it was evaluated
Expert grading and Visioscan analysis compared with baseline; consumer agreement reported separately

See the full finding: EyeCrème — eight-week clinical, consumer, and safety results · Open the study PDF