Does anti-aging skincare actually work?
Quick answer
Yes. Tested SeneGence formulas show visible results on their own study timelines. In an independent eight-week study, the Normal-to-Dry 3 in 1 Cleanser, DayTime Moisturizer and Evening Moisturizer, used together as a regimen, improved measured hydration by 49.99% immediately after application. See the SenePlex+ regimen study. In an independent eight-week study of 32 women using the SenePlex+® Normal-to-Dry regimen (3 in 1 Cleanser – Normal to Dry, DayTime Moisturizer – Normal to Dry and Evening Moisturizer – Normal to Dry), expert grading at week 8 found improved visible brightness, radiance, or luminosity in 96.88% of subjects.
By SeneGence · 
Alan Kante, publisher · Updated
- 3 min read
Which SeneGence treatment fits my concern?
| Concern | Treatment | Its own result | Learn more |
|---|---|---|---|
| Hydration | SeneCell™ SenePlex+® StemCell Concentrate | In an independent eight-week study of 31 women ages 38–75, SeneCell™ SenePlex+® StemCell Concentrate improved measured skin hydration by a mean 56.4% at eight weeks, assessed by a skin-moisture meter compared with baseline. | What SeneCell does · The study |
| Deep wrinkles and volume | GLP Complex™ with SenePlex+® and Exosomes | In an independent study, GLP Complex™ with SenePlex+® and Exosomes reduced the appearance of deep wrinkles by 23.4% at eight weeks. | What GLP Complex does · The study |
| Dark spots and brightness | C-Bright Dark Spot Corrector | In a clinical study of 34 women using C-Bright Dark Spot Corrector, 88% showed measured improvement in skin brightness after eight weeks, assessed by expert observation and image analysis compared with baseline. | What C-Bright does · Beauty Book 2026 |
| Crow’s feet and lines | NeoTight® Rejuvenating Anti-Wrinkle Serum | After six weeks of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 24.53% average improvement in the appearance of crow’s feet. | What the serum does · The study |
What did the SenePlex+ regimen study show?
The SenePlex+® Normal-to-Dry skincare regimen increased hydration after the first use and, by Week 8, improved firmness, radiance, smoothness, tone evenness and line appearance. See the SenePlex+ regimen study or its full findings.
How do I build an anti-aging routine?
Begin with the cleanser, DayTime and Evening Moisturizers for your skin type, and EyeCrème for daily eye-area moisture. Then add one treatment for the concern that matters most and use it consistently: SeneCell™ for concentrated hydration, GLP Complex™ for deep-wrinkle care and the look of facial volume, C-Bright Dark Spot Corrector for brightness and visible discoloration, or NeoTight® Rejuvenating Anti-Wrinkle Serum for firmness and lines. By day, finish skincare with Microbiome Defense Daytime Moisturizer SPF 15; see where SPF goes.
Curious about timing or ingredients? See how long SeneGence skincare takes to work, whether peptides work and what retinol does. SeneCell, GLP Complex, C-Bright or NeoTight.
Study results at a glance
SenePlex+ Normal-to-Dry regimen — eight-week skin quality17 results
| Result | Kind of result | When it was measured |
|---|---|---|
| The tested SenePlex+ regimen improved measured hydration by 49.99% immediately after application. | Measured result | immediate |
| The tested SenePlex+ regimen improved measured hydration by 12.5% at week 2. | Measured result | 2 weeks |
| The tested SenePlex+ regimen improved measured firmness by 7.06% at week 2 on the Cutometer R0 parameter, where a lower value indicates firmer skin. | Measured result | 2 weeks |
| The tested SenePlex+ regimen improved measured hydration by 12.0% at week 4. | Measured result | 4 weeks |
| The tested SenePlex+ regimen improved measured hydration by 28.62% at 8 weeks. | Measured result | 8 weeks |
Show 12 more results
| Result | Kind of result | When it was measured |
|---|---|---|
| The tested SenePlex+ regimen improved measured firmness by 6.59% at week 8 on the Cutometer R0 parameter, where a lower value indicates firmer skin. | Measured result | 8 weeks |
| In an independent eight-week study of 32 women using the SenePlex+® Normal-to-Dry regimen (3 in 1 Cleanser – Normal to Dry, DayTime Moisturizer – Normal to Dry and Evening Moisturizer – Normal to Dry), expert grading at week 8 found improved visible brightness, radiance, or luminosity in 96.88% of subjects. | Expert assessment | 8 weeks |
| At week 8, expert grading found improved visible firmness in 80.65% of subjects using the tested regimen. | Expert assessment | 8 weeks |
| At week 8, expert grading found improved visible texture or smoothness in 71.88% of subjects using the tested regimen. | Expert assessment | 8 weeks |
| At week 8, expert grading found improved visible tone evenness in 56.25% of subjects using the tested regimen. | Expert assessment | 8 weeks |
| At week 8, expert grading found improvement in the appearance of fine lines or wrinkles in 31.25% of subjects using the tested regimen. | Expert assessment | 8 weeks |
| At week 8, 100% of subjects agreed that skin felt more moisturized. | Participant feedback | 8 weeks |
| At week 8, 100% of subjects agreed that skin tone looked more supple. | Participant feedback | 8 weeks |
| At week 8, 100% of subjects agreed that skin texture felt smoother. | Participant feedback | 8 weeks |
| In an independent eight-week study of 32 women using the SenePlex+® Normal-to-Dry regimen (3 in 1 Cleanser – Normal to Dry, DayTime Moisturizer – Normal to Dry and Evening Moisturizer – Normal to Dry), 96.88% agreed at week 8 that their skin looked more luminous, radiant, or bright. | Participant feedback | 8 weeks |
| At week eight, 96.88% of participants said they would buy the Normal-to-Dry 3-in-1 Cleanser, DayTime Moisturizer, and Evening Moisturizer regimen. | Participant feedback | 8 weeks |
| At week 8, expert grading found a 23.60% mean improvement in visible radiance in the tested Normal-to-Dry three-product regimen. | Expert assessment | 8 weeks |
See the full finding: SenePlex+ Normal-to-Dry regimen — eight-week skin quality · Open the study PDF
SeneCell™ SenePlex+® StemCell Concentrate — hydration study11 results
| Result | Kind of result | When it was measured |
|---|---|---|
| In an independent eight-week study of 31 women ages 38–75, SeneCell™ SenePlex+® StemCell Concentrate improved measured skin hydration by a mean 73.9% immediately after application, assessed by a skin-moisture meter compared with baseline. | Measured result | immediate |
| All 31 participants showed measured improvement in skin hydration immediately after applying SeneCell. | Measured result | immediate |
| In an independent eight-week study of 31 women ages 38–75, SeneCell™ SenePlex+® StemCell Concentrate improved measured skin hydration by a mean 42.5% at 24 hours, assessed by a skin-moisture meter compared with baseline. | Measured result | 24 hours |
| At 24 hours, 81% of participants showed measured improvement in skin hydration after using SeneCell. | Measured result | 24 hours |
| In an independent eight-week study of 31 women ages 38–75, SeneCell™ SenePlex+® StemCell Concentrate improved measured skin hydration by a mean 32.5% at 48 hours, assessed by a skin-moisture meter compared with baseline. | Measured result | 48 hours |
Show 6 more results
| Result | Kind of result | When it was measured |
|---|---|---|
| At 48 hours, 81% of participants showed measured improvement in skin hydration after using SeneCell. | Measured result | 48 hours |
| In an independent eight-week study of 31 women ages 38–75, SeneCell™ SenePlex+® StemCell Concentrate improved measured skin hydration by a mean 22.1% at four weeks, assessed by a skin-moisture meter compared with baseline. | Measured result | 4 weeks |
| At 4 weeks, 74% of participants showed measured improvement in skin hydration after using SeneCell. | Measured result | 4 weeks |
| In an independent eight-week study of 31 women ages 38–75, SeneCell™ SenePlex+® StemCell Concentrate improved measured skin hydration by a mean 56.4% at eight weeks, assessed by a skin-moisture meter compared with baseline. | Measured result | 8 weeks |
| All 31 participants showed measured improvement in skin hydration after 8 weeks of using SeneCell. | Measured result | 8 weeks |
| No irritation was observed among the 31 participants during the eight-week SeneCell study. | Safety testing | 8-week study |
See the full finding: SeneCell™ SenePlex+® StemCell Concentrate — hydration study · Open the study PDF
GLP Complex™ with SenePlex+® and Exosomes — wrinkles and facial-volume study5 results
| Result | Kind of result | When it was measured |
|---|---|---|
| In an independent study of 31 participants measured by image analysis, GLP Complex™ with SenePlex+® and Exosomes reduced the appearance of deep wrinkles by 11.2% at four weeks. | Measured result | 4 weeks |
| All 31 participants showed image-analyzed improvement in deep-wrinkle appearance after four and eight weeks of using GLP Complex™ with SenePlex+® and Exosomes. | Measured result | 4 and 8 weeks |
| In an independent study, GLP Complex™ with SenePlex+® and Exosomes reduced the appearance of deep wrinkles by 23.4% at eight weeks. | Measured result | 8 weeks |
| In an independent study, GLP Complex™ with SenePlex+® and Exosomes improved the look of facial volume by 8.4% at eight weeks. | Measured result | 8 weeks |
| At eight weeks, 81% of participants showed image-analyzed improvement in the look of facial volume after using GLP Complex™ with SenePlex+® and Exosomes. | Measured result | 8 weeks |
See the full finding: GLP Complex™ with SenePlex+® and Exosomes — wrinkles and facial-volume study · Open the study PDF
NeoTight® Rejuvenating Anti-Wrinkle Serum — one-hour and six-week study20 results
| Result | Kind of result | When it was measured |
|---|---|---|
| In an independent study, Rejuvenating Anti-Wrinkle Serum improved measured net skin elasticity by 7.65% one hour after a single application. | Measured result | baseline to 1 hour after a single application |
| One hour after a single application of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 12.05% average improvement in firmer-looking skin. | Expert assessment | 1 hour after a single application |
| At week 6, 84.38% of participants agreed that they liked how their skin felt immediately after applying Rejuvenating Anti-Wrinkle Serum. | Participant feedback | week-6 questionnaire about immediate application feel |
| After six weeks of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 24.53% average improvement in the appearance of crow’s feet. | Expert assessment | 6 weeks |
| After six weeks of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 13.64% average improvement in the appearance of upper-lip lines. | Expert assessment | 6 weeks |
Show 15 more results
| Result | Kind of result | When it was measured |
|---|---|---|
| After six weeks of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 7.14% average improvement in the appearance of nasolabial folds. | Expert assessment | 6 weeks |
| At week 6, 96.88% of participants agreed that Rejuvenating Anti-Wrinkle Serum hydrated their skin well. | Participant feedback | 6 weeks |
| At week 6, 87.50% of participants agreed that Rejuvenating Anti-Wrinkle Serum improved their skin's overall appearance. | Participant feedback | 6 weeks |
| At week 6, 84.38% of participants agreed that NeoTight® Rejuvenating Anti-Wrinkle Serum reduced the appearance of fine lines and wrinkles. | Participant feedback | 6 weeks |
| At week 6, 78.13% of participants agreed that NeoTight® Rejuvenating Anti-Wrinkle Serum reduced the appearance of crow's feet around the eyes. | Participant feedback | 6 weeks |
| At week 6, 62.50% of participants agreed that NeoTight® Rejuvenating Anti-Wrinkle Serum reduced the appearance of nasolabial folds. | Participant feedback | 6 weeks |
| At week 6, 71.88% of participants agreed that NeoTight® Rejuvenating Anti-Wrinkle Serum reduced the appearance of upper-lip lines. | Participant feedback | 6 weeks |
| At week 6, 75.00% of participants agreed that their face appeared more youthful after using Rejuvenating Anti-Wrinkle Serum. | Participant feedback | 6 weeks |
| At week 6, 75.00% of participants agreed that their skin felt firmer after using Rejuvenating Anti-Wrinkle Serum. | Participant feedback | 6 weeks |
| At week 6, 71.88% of participants agreed that their skin appeared tighter after using Rejuvenating Anti-Wrinkle Serum. | Participant feedback | 6 weeks |
| At week 6, 96.88% of participants agreed that their skin tolerated Rejuvenating Anti-Wrinkle Serum well without sensitivities. | Participant feedback | 6 weeks |
| At week 6, 84.38% of participants agreed that they liked the color, texture, smell, and feel of Rejuvenating Anti-Wrinkle Serum. | Participant feedback | 6 weeks |
| At week 6, 71.88% of participants agreed that Rejuvenating Anti-Wrinkle Serum absorbed well and did not feel greasy or tacky. | Participant feedback | 6 weeks |
| At week 6, 87.50% of participants agreed that they liked Rejuvenating Anti-Wrinkle Serum overall. | Participant feedback | 6 weeks |
| At week 6, 71.88% of participants agreed that they noticed a firmer-looking, more lifted appearance after applying Rejuvenating Anti-Wrinkle Serum. | Participant feedback | week-6 questionnaire about appearance after application |
See the full finding: NeoTight® Rejuvenating Anti-Wrinkle Serum — one-hour and six-week study · Open the study PDF