Does serum or moisturizer go on first?

1. Cleanse with the 3 in 1 Cleanser for your skin type.
2. Climate Control®. Pump a nickel-size amount or more as desired onto the back of your hand and palette the gel essence over your face, neck, around the eyes and décolletage. See what Climate Control does or Climate Control.
3. GLP Complex™ with SenePlex+® and Exosomes visibly restores lost facial volume. On clean, dry skin, press two to three pumps of GLP Complex into areas that may look hollow or sagging, like the cheeks, under-eyes, smile lines and jawline, then smooth over face and neck. See what GLP Complex does or GLP Complex.
4. SeneCell™ SenePlex+® StemCell Concentrate is the hydration-rich final treatment. Smooth two pumps of SeneCell over face and neck, morning and night. See what SeneCell does or SeneCell.
5. NeoTight™ Eye Serum, then EyeCrème, around the eyes. Use your ring finger to stipple a small amount around the eye area, morning and evening, after cleansing and before moisturizer. See the EyeCrème directions.
6. Nangai Oil, when skin feels dry, tight or depleted. Use three to five drops of Nangai Oil after treatments and before DayTime or Evening Moisturizer.
7. DayTime or Evening Moisturizer for your skin type.
8. Morning sun protection. Microbiome Defense Daytime Moisturizer SPF 15 gives broad-spectrum UVA/UVB protection with Zinc Oxide 6% and Octisalate 5%. See the sunscreen label. Apply Microbiome Defense Daytime Moisturizer SPF 15 generously and evenly as the last skincare step, 15 minutes before sun exposure, and reapply at least every 2 hours; use a water-resistant sunscreen if swimming or sweating. See where SPF goes in your routine.

Let each layer settle before the next. Using other SeneGence treatments? C-Bright Dark Spot Corrector goes on cleansed skin before your serums, and NeoTight® Rejuvenating Anti-Wrinkle Serum goes on targeted expression lines before moisturizer.

Why does Climate Control go on before your serums?

Climate Control® deeply hydrates and prepares skin for treatment actives. Its gel essence mimics the skin’s Natural Moisturizing Factor, supports the barrier and helps optimize delivery and absorption of the beneficial ingredients that follow. Beauty Book 2026 (p. 14).

Where does Nangai Oil fit, and why?

When skin feels dry, tight or depleted, add three to five drops of Nangai Oil after your serums and before moisturizer. Nangai Oil is a triglyceride-rich facial oil led by Canarium Indicum (Nangai) Seed Oil, with Jojoba Oil/Macadamia Seed Oil Esters, Squalene, Phytosteryl Macadamiate, Phytosterols, Limnanthes Alba (Meadowfoam) Seed Oil, and Squalane helping support the skin barrier, moisture retention, softness, and a youthful-looking glow. Its blend mirrors the skin’s own lipids. Nangai Oil is a biomimetic^* facial oil. Open the skin-lipid evidence or Nangai Oil.

Which moisturizer comes next?

After Nangai Oil, finish with the moisturizer for the time of day from the family that suits your skin.

For skin that often feels tight or short on comfort after cleansing, the Dry routine pairs DayTime Moisturizer – Dry, the lighter morning finish, with Evening Moisturizer – Dry, the richer night cream. Shop in the Beauty Book, DayTime Moisturizer – Dry or Evening Moisturizer – Dry.

If Dry feels too rich, compare the Normal-to-Dry day and evening pair. DayTime Moisturizer – Normal to Dry gives Normal-to-Dry skin a lightweight, luminous morning finish, and Evening Moisturizer – Normal to Dry is the richer night cream. Shop DayTime Moisturizer – Normal to Dry in the Beauty Book · p. 12 · PDF, Evening Moisturizer – Normal to Dry or Normal-Dry SkinCare Regimen Set.

For combination or oily skin, finish with DayTime Moisturizer – Normal to Oily in the morning and Evening Moisturizer – Normal to Oily at night. Shop DayTime Moisturizer – Normal to Oily in the Beauty Book · p. 13 · PDF, Evening Moisturizer – Normal to Oily or Normal-Oily SkinCare Regimen Set, or compare every SeneGence moisturizer.

What if the layers pill?

Keep the same order. Notice where the rolling begins, during skincare or only when primer and foundation follow, then use the step-by-step pilling check to find the first layer that rolls.