What does retinol do for skin, and how do I start SeneGence retinol?
Quick answer
Retinol helps skin look brighter and firmer, with less noticeable fine lines over time, and SeneGence Advanced SenePlex+® Renewal Serum with Retinol pairs Retinol and Retinyl Palmitate with Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7. In a six-week independent consumer study, 88% of women agreed their face looked more youthful after using Advanced SenePlex+® Renewal Serum with Retinol. Start SeneGence Advanced SenePlex+® Renewal Serum with Retinol every other night on a clean face, follow with Evening Moisturizer, and move to nightly use as your skin tolerates it.
- 3 min read
- SenePlex+®
- Peptides
What does the serum do for my skin?
Advanced SenePlex+® Renewal Serum with Retinol smooths the look of lines, texture and discoloration overnight with encapsulated Retinyl Palmitate, targeted peptides and growth factors. Over time, Advanced SenePlex+® Renewal Serum with Retinol supports a visible reduction in fine lines and wrinkles, smooths texture and refines tone overnight, and helps support firmness and hydration. Beauty Book 2026 (p. 16). In the same consumer study, women felt the difference too. In a six-week independent consumer study, 85% of women agreed that Advanced SenePlex+® Renewal Serum with Retinol helped their skin feel firmer.
How do I start during the first week?
Apply 1-2 pumps of the product onto clean face, concentrating on areas of concern. Follow with SeneGence Evening Moisturizer. Start using every other night and increase to nightly use as tolerated. Use a broad-spectrum sunscreen with a minimum of SPF 15 and avoid sun exposure while using retinol. For external use only. Avoid contact with eyes. If contact occurs, rinse thoroughly with water. Discontinue use if signs of irritation or rash appear. Keep out of the reach of children. In practice, that means an evening with retinol, then an evening without, until your skin is comfortable with nightly use. Advanced SenePlex+® Renewal Serum with Retinol suits all skin types, especially visible signs of aging. Read the official ingredients and directions.
What should I use by day while I use retinol?
For daytime sun protection while you use retinol, finish your morning skincare before primer and foundation with this step: Microbiome Defense Daytime Moisturizer SPF 15 gives broad-spectrum UVA/UVB protection with Zinc Oxide 6% and Octisalate 5%. See its sunscreen label. Apply Microbiome Defense Daytime Moisturizer SPF 15 generously and evenly as the last skincare step, 15 minutes before sun exposure, and reapply at least every 2 hours; use a water-resistant sunscreen if swimming or sweating. Microbiome Defense Daytime Moisturizer SPF 15 or see where SPF goes.
Which forms of vitamin A does it carry?
The serum carries two forms of vitamin A: micro-encapsulated Retinol for sustained release, and encapsulated Retinyl Palmitate. Retinyl Palmitate at 0.5% provides encapsulated vitamin A care for lines, tone and texture overnight, with Retinol beside it as a second form of vitamin A for brighter, firmer-looking skin and less noticeable fine lines. The serum’s retinol is micro-encapsulated for sustained release. Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 help support elasticity for firmer-looking skin, and their maker pairs them for smoother-looking skin and visible repair; each peptide carries palmitic acid, the palmitoyl in its name. The five growth factors—sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-11 and sh-Polypeptide-9—targets the appearance of lines, wrinkles and sagging. Nephelium Lappaceum (Rambutan) Leaf Extract complements that renewal care, Limnanthes Alba (Meadowfoam) Seed Oil, Aloe Barbadensis (Aloe Vera) Leaf Juice and a hyaluronate complex bring hydrating, calming care, and SenePlex+® completes the formula. Explore Retinol, the rambutan leaf and the smoothing peptide pair. Using vitamin C too? See whether you can use retinol and vitamin C together.
Benefits, formula & use
Advanced SenePlex+® Renewal Serum with Retinol
- Benefits
- Choose Advanced SenePlex+® Renewal Serum with Retinol, our nighttime retinol serum, to minimize the appearance of fine lines and wrinkles, smooth texture and refine tone overnight for brighter, firmer-looking, more youthful skin.
- Application
- Apply 1-2 pumps of the product onto clean face, concentrating on areas of concern. Follow with SeneGence Evening Moisturizer. Start using every other night and increase to nightly use as tolerated. Use a broad-spectrum sunscreen with a minimum of SPF 15 and avoid sun exposure while using retinol. Caution: For external use only. Avoid contact with eyes. If contact occurs, rinse thoroughly with water. Discontinue use if signs of irritation or rash appear. Keep out of the reach of children.
SeneGence Beauty Book 2026, p. 16 · Current formula and directions: official SeneGence product page · View Advanced SenePlex+® Renewal Serum with Retinol on SeneGence
Advanced SenePlex+® Renewal Serum with Retinol
Choose Advanced SenePlex+® Renewal Serum with Retinol, our nighttime retinol serum, to minimize the appearance of fine lines and wrinkles, smooth texture and refine tone overnight for brighter, firmer-looking, more youthful skin.
SenePlex+®How to use Advanced SenePlex+® Renewal Serum with Retinol
Apply 1-2 pumps of the product onto clean face, concentrating on areas of concern. Follow with SeneGence Evening Moisturizer. Start using every other night and increase to nightly use as tolerated. Use a broad-spectrum sunscreen with a minimum of SPF 15 and avoid sun exposure while using retinol. Caution: For external use only. Avoid contact with eyes. If contact occurs, rinse thoroughly with water. Discontinue use if signs of irritation or rash appear. Keep out of the reach of children.
Read the ingredients
Aqua/Water/Eau Caprylic/Capric Triglyceride Propanediol Glycerin Hydrogenated Vegetable Glyceride C12-15 Alkyl Benzoate Limnanthes Alba (Meadowfoam) Seed Oil Myristyl Myristate Behenyl Alcohol Cetyl Alcohol Retinol Oryza Sativa (Rice) Bran Extract Aloe Barbadensis (Aloe Vera) Leaf Juice Helianthus Annuus (Sunflower) Extract Nephelium Lappaceum (Rambutan) Leaf Extract Rosmarinus Officinalis (Rosemary) Leaf Extract Bacillus/Folic Acid Ferment Filtrate Extract Laminaria Digitata (Kelp) Extract Saccharomyces Cerevisiae (Yeast) Extract Orchis Mascula (Orchid) Flower Extract Sh-Oligopeptide-1 Sh-Oligopeptide-2 Sh-Polypeptide-1 Sh-Polypeptide-11 Sh-Polypeptide-9 Palmitoyl Tripeptide-1 Palmitoyl Tetrapeptide-7 Hydrolyzed Sodium Hyaluronate Sodium Hyaluronate Sodium Acetylated Hyaluronate Sodium Hyaluronate Crosspolymer-2 Glucosamine HCl Retinyl Palmitate Galactoarabinan Tocopherol Tocopheryl Acetate Panthenol Sodium Stearoyl Glutamate Sodium Polyacrylate Linoleic Acid Oleic Acid Steareth-2 Glyceryl Stearate Acetyl Glutamine Lecithin Stearyl Alcohol Ethylhexylglycerin Sorbitan Laurate Dimethicone/Vinyl Dimethicone Crosspolymer Maltodextrin C18-36 Acid Glycol Ester C18-36 Acid Triglyceride Pentylene Glycol Trisodium Ethylenediamine Disuccinate Butylene Glycol Caprylyl Glycol Urea* Citric Acid Cyclopentasiloxane Polysorbate 20 Polysorbate 80 Polyglyceryl-2 Stearate PPG-15 Stearyl Ether Phenoxyethanol Parfum/Fragrance Benzyl Salicylate Linalool Geraniol Hydroxycitronellal Citronellol Limonene Titanium Dioxide (CI 77891). *Synthetic
Full ingredient list
Advanced SenePlex+® Renewal Serum with RetinolIngredient guide
Aqua/Water/Eau Caprylic/Capric Triglyceride Propanediol Glycerin Hydrogenated Vegetable Glyceride C12-15 Alkyl Benzoate Limnanthes Alba (Meadowfoam) Seed Oil Myristyl Myristate Behenyl Alcohol Cetyl Alcohol Retinol Oryza Sativa (Rice) Bran Extract Aloe Barbadensis (Aloe Vera) Leaf Juice Helianthus Annuus (Sunflower) Extract Nephelium Lappaceum (Rambutan) Leaf Extract Rosmarinus Officinalis (Rosemary) Leaf Extract Bacillus/Folic Acid Ferment Filtrate Extract Laminaria Digitata (Kelp) Extract Saccharomyces Cerevisiae (Yeast) Extract Orchis Mascula (Orchid) Flower Extract Sh-Oligopeptide-1 Sh-Oligopeptide-2 Sh-Polypeptide-1 Sh-Polypeptide-11 Sh-Polypeptide-9 Palmitoyl Tripeptide-1 Palmitoyl Tetrapeptide-7 Hydrolyzed Sodium Hyaluronate Sodium Hyaluronate Sodium Acetylated Hyaluronate Sodium Hyaluronate Crosspolymer-2 Glucosamine HCl Retinyl Palmitate Galactoarabinan Tocopherol Tocopheryl Acetate Panthenol Sodium Stearoyl Glutamate Sodium Polyacrylate Linoleic Acid Oleic Acid Steareth-2 Glyceryl Stearate Acetyl Glutamine Lecithin Stearyl Alcohol Ethylhexylglycerin Sorbitan Laurate Dimethicone/Vinyl Dimethicone Crosspolymer Maltodextrin C18-36 Acid Glycol Ester C18-36 Acid Triglyceride Pentylene Glycol Trisodium Ethylenediamine Disuccinate Butylene Glycol Caprylyl Glycol Urea* Citric Acid Cyclopentasiloxane Polysorbate 20 Polysorbate 80 Polyglyceryl-2 Stearate PPG-15 Stearyl Ether Phenoxyethanol Parfum/Fragrance Benzyl Salicylate Linalool Geraniol Hydroxycitronellal Citronellol Limonene Titanium Dioxide (CI 77891).
*Synthetic
Official product reference checked September 18, 2026. View Advanced SenePlex+® Renewal Serum with Retinol on SeneGence