Skip to content

Product Basics

Complete SeneGence Skincare Routine

Morning should feel light enough for sunscreen and makeup; evening should end richer. This complete SeneGence routine starts with the skin-type Core 4, keeps the Triple Cell Renewal Trio in order, adds Nangai Oil only when skin feels dry, tight or depleted, and saves Collagen Firming Night Pak for the final evening finish.

Start with the Core 4

Start with the Core 4
Start with the Core 4

The four products that stay in the routine are the Core 4: 3-in-1 Cleanser, DayTime Moisturizer, Evening Moisturizer and EyeCrème. Together they cover cleansing, lighter morning moisture, richer evening moisture and dedicated eye-area care.

This complete example brings in the Triple Cell Renewal Trio, followed by Nangai Oil to condition skin after treatments and before moisturizer when skin feels dry, tight or depleted. In the morning, labeled sun protection such as Microbiome Defense Daytime Moisturizer SPF 15 goes on as directed, and evening care closes with Collagen Firming Night Pak. Each addition has a time and a job; those four remain the foundation.

Each skin type has its own Core 4, from the Normal-to-Oily set to the Normal-to-Dry formulas this routine follows.

how to use it

Begin with how your skin behaves now, then match the 3-in-1 Cleanser, DayTime Moisturizer and Evening Moisturizer to it; EyeCrème completes the four. The morning and evening cards show the exact Normal-to-Dry amounts and order. Keep the Trio in its one sequence. Add Nangai Oil only when the condition calls for it. Stipple EyeCrème after cleansing and before moisturizer, and let Night Pak end the evening routine.

the science

The Core 4 gives the day two different finishes from one consistent base. Cleanser clears the surface before leave-on care. The daytime emulsion supplies the lighter morning moisture layer; the evening emulsion supplies the richer overnight finish; EyeCrème goes on before facial moisturizer in its directed zone. Before those creams, the Trio moves through lightweight hydration, targeted care for visibly restored facial volume and concentrated hydration. Nangai Oil contributes a conditional lipid-rich step, and Night Pak supplies the final nourishing, occlusive finish. See the Core 4 record and the complete application-order answer.

Choose the right skin-type system

Choose the right skin-type system
Choose the right skin-type system

The worked routine follows Normal to Dry: 3 in 1 Cleanser - Normal to Dry, DayTime Moisturizer - Normal to Dry, and Evening Moisturizer - Normal to Dry. Its morning moisturizer leaves the lighter, radiant layer; its evening cream brings the richer moisture-and-renewal finish.

Together, these three Normal-to-Dry formulas brought a measurable moisture boost in an independent eight-week study.

The tested SenePlex+ regimen improved measured hydration by 49.99% immediately after application.

The tested SenePlex+ regimen improved measured hydration by 28.62% at 8 weeks.

See the Normal-to-Dry regimen results.

Persistent tightness with low oil points toward Dry. Skin that is generally comfortable but wants more reserve points toward Normal to Dry. T-zone shine or combination behavior points toward Normal to Oily. Sensitive, oily, troubled, or stressed-feeling skin may point toward the Microbiome Collection.

Switching skin types? Follow that system's own directions and amounts; the ones here are for the Normal-to-Dry trio.

how to use it

After cleansing, wait and look at what the surface does. Persistent tightness with low oil points to Dry; comfortable skin wanting more reserve to Normal to Dry; T-zone shine or combination behavior to Normal to Oily; sensitivity or barrier discomfort may point to Microbiome. Keep the cleanser and facial moisturizers in the same skin-type system, then reassess comfort and shine when conditions change. The one-to-two-pump DayTime amount and quarter-size Evening amount belong only to these Normal-to-Dry formulas.

the science

Skin type is a reading of present surface behavior, not a permanent identity. A Normal to Oily 3-in-1 Cleanser begins the oil-prone system; Dry and Normal to Dry change the emollient and occlusive emphasis; Microbiome follows a separate collection structure. In DayTime Moisturizer - Normal to Dry, knotgrass (Polygonum Aviculare Extract) helps soften the visible signs of photo-aging, while Squalane leaves skin feeling soft and smooth. The lightweight morning cream boosts hydration and radiance. Evening Moisturizer - Normal to Dry brings richer moisture and supports natural renewal overnight. Compare the exact Normal-to-Dry pair.

Build the morning routine

Build the morning routine
Build the morning routine

A Normal-to-Dry morning builds toward a light, protected finish.

1. On moist face and neck, gently massage 3 in 1 Cleanser - Normal to Dry, then rinse thoroughly. 2. Pump a nickel-size amount of Climate Control onto the back of your hand and palette the gel essence over your face, neck, around the eyes and décolletage. It is the hydration primer that helps prepare the skin barrier for the serum benefits that follow. 3. Press two to three pumps of GLP Complex™ into cheeks, under-eyes, smile lines and jawline, then smooth over face and neck. 4. Apply two pumps of SeneCell™ to face and neck. Use this Trio order: Climate Control → GLP Complex™ → SeneCell™. 5. When skin feels dry, tight or depleted, gently shake Nangai Oil, dispense three to five drops into a clean palm, and pat it onto the face or target area after treatments and before moisturizer. If the oil has solidified, warm it between your hands until it liquefies. 6. Use the ring finger to stipple EyeCrème around the eye area, after cleansing and before moisturizer. 7. Apply one to two pumps of DayTime Moisturizer - Normal to Dry evenly to face and neck. 8. Finish with labeled sun protection, such as Microbiome Defense Daytime Moisturizer SPF 15. Apply Microbiome Defense Daytime Moisturizer SPF 15 generously and evenly as the last skincare step, 15 minutes before sun exposure, and reapply at least every 2 hours; use a water-resistant sunscreen if swimming or sweating.

If makeup follows, continue with the directed primer and foundation steps. Together, DayTime Moisturizer, MakeSense Silk Primer & Pore Minimizer, and MakeSense Foundation form the Mechanical Shield.

how to use it

The morning textures tell the order. Climate Control begins with light hydration; GLP Complex™ follows for the look of facial volume and deep-wrinkle appearance; SeneCell™ completes the fixed Trio sequence with concentrated hydration. Nangai Oil remains a condition-led lipid step after treatment and before moisturizer, never a fourth Trio product. EyeCrème, DayTime Moisturizer - Normal to Dry and Microbiome Defense Daytime Moisturizer SPF 15 close morning care in that order; primer and foundation follow by their current directions. Open MakeSense Silk Primer & Pore Minimizer and its current official page, then MakeSense Original Foundation and its current official page.

the science

Morning moves from a freshly cleansed surface into water-light hydration, targeted treatment, conditional lipid support, cream moisture and outer protection. Climate Control wets the surface; GLP Complex™ supplies the volume-support formula; SeneCell™ adds concentrated hydration and resilience-focused care. Nangai Oil contributes emollient comfort only when the skin condition calls for it. Eye-area moisture comes next, then the Normal-to-Dry daytime emulsion adds humectant, emollient and film-forming structure before sunscreen. Open the Trio evidence, Nangai Oil identity, or the complete order answer.

Complete the evening routine

Complete the evening routine
Complete the evening routine

At night, remove the day's color first and let the routine finish richer.

1. When face or eye makeup was worn, shake Fooops!® Dual Phase Color Remover, spread a small amount from the palm over the face, let it sit about 20 seconds, then remove with a warm, wet washcloth. When LipSense was worn, use Ooops!™ Lip Color Remover: dip the wand, gently work the applicator over the color and wipe clean with tissue. 2. Massage 3 in 1 Cleanser - Normal to Dry over moist face and neck, then rinse thoroughly. 3. Repeat the Trio in order: pump Climate Control onto the back of your hand and palette it over face and neck, then follow with two to three pumps of GLP Complex™, then two pumps of SeneCell™. 4. If skin feels dry, tight or depleted, gently shake Nangai Oil, dispense three to five drops into a clean palm, and pat it onto the face or target area after treatments and before moisturizer. If the oil has solidified, warm it between your hands until it liquefies. 5. Stipple EyeCrème around the eye area, after cleansing and before moisturizer. 6. Massage a quarter-size amount of Evening Moisturizer - Normal to Dry over face and neck, then press and roll with fingertips. 7. Every night or as desired, finish with Collagen Firming Night Pak. Dispense about a dime-size amount onto the back of the hand, then use clean fingertips or the contoured applicator brush (not included) to sweep a thin, even layer upward from décolletage through throat to face. Night Pak is the last layer your skin wears overnight.

how to use it

Start with the remover made for the color that was worn, then cleanse. Repeat the Trio in this order and use the directed amounts at night; add Nangai Oil after treatment only when skin feels dry, tight or depleted. EyeCrème goes on before Evening Moisturizer - Normal to Dry, which brings the richer cream. Collagen Firming Night Pak is a separate final treatment, never a moisturizer replacement, and may be used every night or as desired. See Night Pak directions.

the science

Removing long-wear pigment and film gives cleanser a clear surface to begin the evening sequence. The Trio restores the water-light-to-treatment progression. When the skin condition calls for it, Nangai Oil's triglyceride-rich formula, led by Canarium indicum seed oil, places emollient lipid comfort between treatments and cream. Evening Moisturizer - Normal to Dry follows with richer moisture and support for natural renewal overnight. Above it, Collagen Firming Night Pak combines seaweed and algae extracts, Nangai Oil and soothing botanicals in an occlusive, moisture-locking finish for a firmer, smoother-looking morning complexion. See the Normal-to-Dry moisturizer evidence and the removal guide.

Know what every added layer contributes

In the morning, the treatment layers stay light. Climate Control prepares with lightweight hydration; GLP Complex™ addresses the look of facial volume and deep-wrinkle appearance; SeneCell™ completes the Trio with concentrated hydration and firmer-, lifted-looking care.

Nangai Oil is a biomimetic* facial oil.

When skin feels dry, tight or depleted, reach for Nangai Oil for lipid comfort after treatments and before moisturizer. EyeCrème brings dedicated eye-area moisture before your facial moisturizer, and DayTime Moisturizer - Normal to Dry adds the lighter, radiant morning cream.

Evening ends differently. Evening Moisturizer - Normal to Dry brings the richer moisture-and-renewal cream. Collagen Firming Night Pak goes last as the nourishing, occlusive layer that helps lock in moisture and supports a firmer, smoother-looking complexion by morning.

Prepare, treat, condition when needed, moisturize, then give morning or night its proper finish.

how to use it

Keep the choices easy to explain at the mirror: the Trio always holds one order; Nangai Oil is conditional after treatment; the matched day and evening creams create different finishes; EyeCrème goes on before facial moisturizer; Night Pak remains separate and last. The Trio lesson gives the formula detail, while the skincare-order answer shows the complete sequence.

the science

The textures explain why the routine changes as it rises: water-light preparation, targeted treatment, conditional emollient oil, cream emulsion, then an occlusive final night layer. For a closer look at each choice, see Triple Cell Renewal Trio order and roles, Nangai Oil identity and barrier-support role, Normal-to-Dry day/night moisturizer comparison, and Collagen Firming Night Pak identity and directions. Why Skincare Application Order Matters shows why each texture takes its place in the sequence.

Study results at a glance

SenePlex+ Normal-to-Dry regimen — eight-week skin quality17 results
SenePlex+ Normal-to-Dry regimen — eight-week skin quality
ResultKind of resultWhen it was measured
The tested SenePlex+ regimen improved measured hydration by 49.99% immediately after application.Measured resultimmediate
The tested SenePlex+ regimen improved measured hydration by 12.5% at week 2.Measured result2 weeks
The tested SenePlex+ regimen improved measured firmness by 7.06% at week 2 on the Cutometer R0 parameter, where a lower value indicates firmer skin.Measured result2 weeks
The tested SenePlex+ regimen improved measured hydration by 12.0% at week 4.Measured result4 weeks
The tested SenePlex+ regimen improved measured hydration by 28.62% at 8 weeks.Measured result8 weeks
Show 12 more results
SenePlex+ Normal-to-Dry regimen — eight-week skin quality, more results
ResultKind of resultWhen it was measured
The tested SenePlex+ regimen improved measured firmness by 6.59% at week 8 on the Cutometer R0 parameter, where a lower value indicates firmer skin.Measured result8 weeks
In an independent eight-week study of 32 women using the SenePlex+® Normal-to-Dry regimen (3 in 1 Cleanser – Normal to Dry, DayTime Moisturizer – Normal to Dry and Evening Moisturizer – Normal to Dry), expert grading at week 8 found improved visible brightness, radiance, or luminosity in 96.88% of subjects.Expert assessment8 weeks
At week 8, expert grading found improved visible firmness in 80.65% of subjects using the tested regimen.Expert assessment8 weeks
At week 8, expert grading found improved visible texture or smoothness in 71.88% of subjects using the tested regimen.Expert assessment8 weeks
At week 8, expert grading found improved visible tone evenness in 56.25% of subjects using the tested regimen.Expert assessment8 weeks
At week 8, expert grading found improvement in the appearance of fine lines or wrinkles in 31.25% of subjects using the tested regimen.Expert assessment8 weeks
At week 8, 100% of subjects agreed that skin felt more moisturized.Participant feedback8 weeks
At week 8, 100% of subjects agreed that skin tone looked more supple.Participant feedback8 weeks
At week 8, 100% of subjects agreed that skin texture felt smoother.Participant feedback8 weeks
In an independent eight-week study of 32 women using the SenePlex+® Normal-to-Dry regimen (3 in 1 Cleanser – Normal to Dry, DayTime Moisturizer – Normal to Dry and Evening Moisturizer – Normal to Dry), 96.88% agreed at week 8 that their skin looked more luminous, radiant, or bright.Participant feedback8 weeks
At week eight, 96.88% of participants said they would buy the Normal-to-Dry 3-in-1 Cleanser, DayTime Moisturizer, and Evening Moisturizer regimen.Participant feedback8 weeks
At week 8, expert grading found a 23.60% mean improvement in visible radiance in the tested Normal-to-Dry three-product regimen.Expert assessment8 weeks
Who took part
34 enrolled; 32 completed; women ages 25–70
How it was evaluated
Eight-week dermatologist-supervised monadic study; Corneometer and Cutometer measurements, expert grading, and consumer questionnaire
Statistical context
Hydration significant at every measured timepoint: p<0.001 immediately and at Week 8; p=0.005 at Week 2; p=0.003 at Week 4; expert-grading endpoints statistically significant as reported

See the full finding: SenePlex+ Normal-to-Dry regimen — eight-week skin quality · Open the study PDF

Read another way and explore this topic
Read this guide card by card → Take it at your own pace.