What is the SeneGence Triple Cell Renewal Trio?
Quick answer
The SeneGence Triple Cell Renewal Trio pairs Climate Control, GLP Complex™ with SenePlex+® and Exosomes, and SeneCell™ SenePlex+® StemCell Concentrate for preparation, lost facial volume and deep-wrinkle care, and concentrated hydration.
By SeneGence · 
Alan Kante, publisher · Updated
- 1 min read
- SenePlex+®
What does each product do?
Climate Control is the water-light preparation layer. GLP Complex visibly restores lost facial volume and smooths deep wrinkles. SeneCell adds lightweight, layerable hydration. Explore the Trio’s formula roles.
In an independent study of 31 participants measured by image analysis, GLP Complex™ with SenePlex+® and Exosomes reduced the appearance of deep wrinkles by 11.2% at four weeks and 23.4% at eight weeks, and improved the look of facial volume by 8.4% at eight weeks. GLP Complex clinical report. GLP Complex™ with SenePlex+® and Exosomes — wrinkles and facial-volume study.
In an independent study of 31 women ages 38–75, measured with a skin-moisture meter against baseline, SeneCell™ improved skin hydration by a mean 73.9% immediately after application and 56.4% at eight weeks. SeneCell hydration report. SeneCell™ SenePlex+® StemCell Concentrate — hydration study.
What order do I use?
Apply the Triple Cell Renewal Trio in this order: Climate Control, GLP Complex™ with SenePlex+® and Exosomes, then SeneCell™ SenePlex+® StemCell Concentrate. Follow with EyeCrème, then moisturizer. When skin feels dry, apply Nangai Oil after treatments and before moisturizer. Learn the complete Trio method. the Triple Cell Renewal Trio.
Triple Cell Renewal Trio
Choose the Triple Cell Renewal Trio to layer Climate Control, GLP Complex™ and SeneCell™ in three steps that strengthen the barrier, visibly restore lost facial volume and deliver deep hydration.
Includes formulas with SenePlex+®Powered by stem cell secretomes & growth factor peptides to support cellular renewal and hydration.
Official Triple Cell Renewal Trio product page
How to use Triple Cell Renewal Trio
- STEP 1: DEFEND Apply Climate Control to clean skin to hydrate, strengthen the barrier, and prepare skin for optimal absorption.
- STEP 2: PLUMP Apply 2–3 pumps of GLP Complex™ to clean, dry skin. Gently press into areas prone to volume loss—cheeks, under-eyes, smile lines, and jawline—then smooth over face and neck.
- STEP 3: HYDRATE Apply 2 pumps of SeneCell™ to clean face and neck to deliver deep hydration and support long-term skin renewal. Use morning and evening for best results.
Study results at a glance
GLP Complex™ with SenePlex+® and Exosomes — wrinkles and facial-volume study5 results
| Result | Kind of result | When it was measured |
|---|---|---|
| In an independent study of 31 participants measured by image analysis, GLP Complex™ with SenePlex+® and Exosomes reduced the appearance of deep wrinkles by 11.2% at four weeks. | Measured result | 4 weeks |
| All 31 participants showed image-analyzed improvement in deep-wrinkle appearance after four and eight weeks of using GLP Complex™ with SenePlex+® and Exosomes. | Measured result | 4 and 8 weeks |
| In an independent study, GLP Complex™ with SenePlex+® and Exosomes reduced the appearance of deep wrinkles by 23.4% at eight weeks. | Measured result | 8 weeks |
| In an independent study, GLP Complex™ with SenePlex+® and Exosomes improved the look of facial volume by 8.4% at eight weeks. | Measured result | 8 weeks |
| At eight weeks, 81% of participants showed image-analyzed improvement in the look of facial volume after using GLP Complex™ with SenePlex+® and Exosomes. | Measured result | 8 weeks |
See the full finding: GLP Complex™ with SenePlex+® and Exosomes — wrinkles and facial-volume study · Open the study PDF
SeneCell™ SenePlex+® StemCell Concentrate — hydration study11 results
| Result | Kind of result | When it was measured |
|---|---|---|
| In an independent eight-week study of 31 women ages 38–75, SeneCell™ SenePlex+® StemCell Concentrate improved measured skin hydration by a mean 73.9% immediately after application, assessed by a skin-moisture meter compared with baseline. | Measured result | immediate |
| All 31 participants showed measured improvement in skin hydration immediately after applying SeneCell. | Measured result | immediate |
| In an independent eight-week study of 31 women ages 38–75, SeneCell™ SenePlex+® StemCell Concentrate improved measured skin hydration by a mean 42.5% at 24 hours, assessed by a skin-moisture meter compared with baseline. | Measured result | 24 hours |
| At 24 hours, 81% of participants showed measured improvement in skin hydration after using SeneCell. | Measured result | 24 hours |
| In an independent eight-week study of 31 women ages 38–75, SeneCell™ SenePlex+® StemCell Concentrate improved measured skin hydration by a mean 32.5% at 48 hours, assessed by a skin-moisture meter compared with baseline. | Measured result | 48 hours |
Show 6 more results
| Result | Kind of result | When it was measured |
|---|---|---|
| At 48 hours, 81% of participants showed measured improvement in skin hydration after using SeneCell. | Measured result | 48 hours |
| In an independent eight-week study of 31 women ages 38–75, SeneCell™ SenePlex+® StemCell Concentrate improved measured skin hydration by a mean 22.1% at four weeks, assessed by a skin-moisture meter compared with baseline. | Measured result | 4 weeks |
| At 4 weeks, 74% of participants showed measured improvement in skin hydration after using SeneCell. | Measured result | 4 weeks |
| In an independent eight-week study of 31 women ages 38–75, SeneCell™ SenePlex+® StemCell Concentrate improved measured skin hydration by a mean 56.4% at eight weeks, assessed by a skin-moisture meter compared with baseline. | Measured result | 8 weeks |
| All 31 participants showed measured improvement in skin hydration after 8 weeks of using SeneCell. | Measured result | 8 weeks |
| No irritation was observed among the 31 participants during the eight-week SeneCell study. | Safety testing | 8-week study |
See the full finding: SeneCell™ SenePlex+® StemCell Concentrate — hydration study · Open the study PDF
Full ingredient list
Triple Cell Renewal TrioIngredient guide
Climate Control Aqua/Water/Eau Butylene Glycol Caprylic/Capric Triglyceride Phenyl Trimethicone Lithium Magnesium Sodium Silicate Xylitylglucoside Oenothera Biennis (Evening Primrose) Oil Rosa Canina (Rose Hip) Seed Oil Orchis Mascula (Orchid) Flower Extract Simmondsia Chinensis (Jojoba) Seed Oil Santalum Austrocaledonicum (Sandalwood) Wood Oil Laminaria Digitata (Kelp) Extract Saccharomyces Cerevisiae (Yeast) Extract Calanthe Discolor (Ebine) Extract Aloe Barbadensis (Aloe Vera) Leaf Juice Hydrolyzed Opuntia Ficus-Indica (Prickly Pear) Flower Extract Sodium Hyaluronate Tocopheryl Acetate Anhydroxylitol Xylitol Glucose Urea Glucosamine HCl Panthenol Glycerin Citric Acid Xanthan Gum Gluconolactone 1 2- Hexanediol Caprylyl Glycol Sodium Benzoate Calcium Gluconate Phenoxyethanol Potassium Sorbate Parfum/Fragrance Benzyl Benzoate Linalool Hydroxycitronellal Benzyl Salicylate Hexyl Cinnamal Amyl Cinnamal Citronellol Geraniol Eugenol Cinnamyl Alcohol Limonene Blue 1 (CI 42090) Red 33 (CI 17200). GLP Complex™ with SenePlex+® & Exosomes Aqua/Water/Eau, Glycerin, Sodium Polyacrylate, Lauroyl Lysine, Propanediol, Chondrus Crispus (Carrageenan) Extract, Lecithin, Potassium Sorbate, Sodium Hyaluronate Crosspolymer, Ornithine Hcl, Citric Acid, Parfum/Fragrance, Ethylhexylglycerin, Phospholipids, Benzyl Benzoate, Glycolipids, Aloe Barbadensis (Aloe Vera) Leaf Juice, Trisodium Ethylenediamine Disuccinate, 1, 2-Hexanediol, Gluconolactone, Levulinic Acid, P-Anisic Acid, Sodium Hydroxide, Hexamethylindanopyran, Sodium Benzoate, Linalool, Hydroxycitronellal, Sodium Hyaluronate, Geraniol, Helianthus Annuus (Sunflower) Seed Oil, Tocopherol, Citronellol, Alpha-Isomethyl Ionone, Caprooyl Tetrapeptide-3, Dextran, Tocopheryl Acetate, Panthenol, Butylene Glycol, Calanthe Discolor (Ebine) Extract, Hydrolyzed Opuntia Ficus-Indica (Prickly Pear) Flower Extract, Xanthan Gum, Caprylyl Glycol, Calcium Gluconate, Laminaria Digitata (Kelp) Extract, Saccharomyces Cerevisiae (Yeast) Extract, Orchis Mascula (Orchid) Flower Extract, Centella Asiatica Leaf Vesicles, Phenoxyethanol, Urea*, Glucosamine HCl.
Official product reference checked September 18, 2026. View Triple Cell Renewal Trio on SeneGence