What is the SeneGence Microbiome Collection?

What does each Microbiome formula bring?

Four formulas, each with its own step; Microbiome Boosting Serum is sold separately from the set.

Formula	When to use it	What it does for you	Explore
Microbiome Correcting Cleanser	Morning and evening cleanse	Probiotic cleansing that needs no separate toner, gently clearing congestion and refining texture; Niacinamide, Gluconolactone, Salicylic Acid, Sodium Hyaluronate and Hamamelis Virginiana Water give an oil-aware, soothing, comfortable rinse.	Cleanser formula
Microbiome Boosting Serum	After cleansing, before moisturizer	Helps strengthen the skin’s natural barrier for smoother, healthier-looking skin; Sodium Hyaluronate, Hyaluronic Acid, Sodium Hyaluronate Crosspolymer and Sodium Polyglutamate bind water, and Caulerpa Lentillifera Extract adds antioxidant care.	Boosting Serum formula
Microbiome Defense Daytime Moisturizer SPF 15	Morning, as the last skincare step	Microbiome Defense Daytime Moisturizer SPF 15 gives broad-spectrum UVA/UVB protection with Zinc Oxide 6% and Octisalate 5%. Its antioxidants also help defend against blue light.	Daytime formula · Its sunscreen label
Microbiome Restorative Evening Moisturizer	Evening, as the richer last step	Deep overnight hydration for calmer, clearer-looking skin.	Evening barrier lipids

What does each Microbiome formula do?

Microbiome Correcting Cleanser balances the microbiome with probiotic care, without a separate toner. Gentle exfoliation clears congestion and refines texture while calming sensitive, blemish-prone skin. Two probiotic ferments do the balancing. Microbiome Correcting Cleanser helps balance skin and strengthen its barrier with Streptococcus Thermophilus Ferment, which supports natural Hyaluronic Acid. Niacinamide (Vitamin B3) regulates excess oil for balanced-looking skin. Lactobacillus/Punica Granatum Fruit Ferment Extract brightens, soothes and supports elasticity. Beauty Book 2026 (p. 13). Its mild cleansers give a clean, comfortable rinse rather than a tight one; Niacinamide, Gluconolactone, Salicylic Acid, Sodium Hyaluronate and Hamamelis Virginiana Water bring oil-aware, soothing care; and in cosmetic science the pomegranate ferment supplies enzyme-led exfoliation that helps dead surface cells come away. See the cleanser formula, the Streptococcus thermophilus ferment or Microbiome Correcting Cleanser.

Microbiome Boosting Serum helps strengthen the skin’s natural barrier, helps protect skin from environmental hazards and promotes smoother, more resilient, healthier-looking skin. Beauty Book 2026 (p. 11). Microbiome Boosting Serum carries SenePlex+® with orchid stem cells: Calanthe Discolor (Ebine) Extract and Orchis Mascula (Orchid) Flower Extract join yeast-and-kelp bioferments in its prebiotic formula. Lactobacillus Ferment gives dry-looking skin a supple feel, and Sodium Hyaluronate, Hyaluronic Acid and Sodium Hyaluronate Crosspolymer join Sodium Polyglutamate to bind water without the weight of a rich cream, Caulerpa Lentillifera Extract adds antioxidant care, Sphingomonas Ferment Extract can lend a formula a silky texture. After cleansing your face, dispense 2 to 4(+) pumps into hand. Apply the Microbiome Boosting Serum to your face, neck, and décolletage. Gently massage it into your skin until it is fully absorbed. Microbiome Boosting Serum.

By day, Microbiome Defense Daytime Moisturizer SPF 15 provides broad-spectrum UVA/UVB protection with Zinc Oxide and Octisalate. Antioxidants defend against blue light and environmental stressors, while probiotic care supports microbiome resilience and clearer-looking skin. Beauty Book 2026 (p. 13). It pairs Lactobacillus Ferment with Saccharomyces Ferment Filtrate, a filtered yeast ferment that helps the formula hold water. Apply Microbiome Defense Daytime Moisturizer SPF 15 generously and evenly as the last skincare step, 15 minutes before sun exposure, and reapply at least every 2 hours; use a water-resistant sunscreen if swimming or sweating. See its sunscreen directions or Microbiome Defense Daytime Moisturizer SPF 15.

At bedtime, Microbiome Restorative Evening Moisturizer helps restore microbiome balance overnight. Deep hydration improves the look of tone and texture, while barrier support helps skin look calmer and clearer. It pairs Lactobacillus Ferment with Ceramide NP, Cholesterol and Squalane for richer overnight comfort, and Lactobacillus/Punica Granatum Fruit Ferment Extract, a fermented pomegranate, helps brighten, soothe and support the look of elasticity. Beauty Book 2026 (p. 13). Microbiome Restorative Evening Moisturizer.

Microbiome Boosting Serum, Microbiome Correcting Cleanser, Microbiome Defense Daytime Moisturizer SPF 15 and Microbiome Restorative Evening Moisturizer all carry SenePlex+®: Calanthe Discolor (Ebine) Extract orchid stem cells and Orchis Mascula (Orchid) Flower Extract with yeast-and-kelp bioferments, alongside each formula’s own ferments. What SenePlex+ is.

What is a ferment?

Ferments run through all four formulas, each with its own job. A ferment is made when microorganisms transform a plant or other raw material; what matters is the job it does in the bottle. See ferments in skincare.

Should I buy the Microbiome set?

When skin feels oily, sensitive or stressed, start with the whole routine in one set. The Microbiome SkinCare Regimen Set brings together Microbiome Correcting Cleanser, Microbiome Defense Daytime Moisturizer SPF 15, Microbiome Restorative Evening Moisturizer and EyeCrème, with Microbiome Boosting Serum sold separately. EyeCrème gives the set its eye-area moisture step, and Boosting Serum adds hydration to both routines. Happy with your routine? Start with Boosting Serum alone. See the morning and evening order, step by step.