Science & Ingredients
SeneGence Before and After: The Clinical File
Pick the change you most want to see in your mirror and meet the SeneGence formula tested for it. Learn where it fits in your routine, then see what changed, when it changed and the study behind the result.
By SeneGence · 
Alan Kante, publisher · Updated
Choose a SeneGence Clinical Result by Skin Concern
Start with the change you most want to see in your own mirror.
NeoTight Rejuvenating Anti-Wrinkle Serum is the choice for first-use firmness. For dark circles or puffiness, NeoTight Eye Serum gives the eye area a lightweight treatment before richer moisture. C-Bright Dark Spot Corrector brings brighter-looking, more even tone; EyeCrème gives dry, tired-looking eyes richer comfort. For basics that work together from cleansing through day and night, begin with the SenePlex+ regimen.
Choose your concern, then read the report beside the product. SeneGence Clinicals
how to use it
Start with what you most want to see different—surface hydration, firmer-looking contours or smoother-looking deep wrinkles—then match it to one product and its place in your routine. Open that product’s clinical while you have it in hand, and note your starting concern, the formula you chose and when the study says a re-check becomes meaningful.
the science
The method follows the beauty question: a Cutometer for elasticity, expert grading for visible eye concerns, image analysis for brightness, and skin imaging or consumer feedback for EyeCrème. Each report keeps its product, endpoint, population, and timepoint together. SeneGence Clinicals
NeoTight Rejuvenating Anti-Wrinkle Serum: immediate elasticity
When skin feels less springy and the whole face looks tired, reach for NeoTight Rejuvenating Anti-Wrinkle Serum. Dipeptide Diaminobutyroyl Benzylamide Diacetate gives this firming treatment its peptide focus.
In an independent study, Rejuvenating Anti-Wrinkle Serum improved measured net skin elasticity by 7.65% one hour after a single application.
Apply it as directed on clean, prepared skin before moisturizer, then open the NeoTight Rejuvenating Clinical.
how to use it
When first-use firmness is your goal, place NeoTight Rejuvenating Anti-Wrinkle Serum in the directed treatment step before moisturizer. Note your starting look and feel, then use the one-hour result to frame the immediate checkpoint. Open the NeoTight Rejuvenating Clinical beside the product.
the science
A Cutometer measured net skin elasticity before and one hour after a single application. That method fits the immediate firmness question. The later six-week endpoints address visible appearance and participant experience on their own timeline. NeoTight Rejuvenating evidence record
NeoTight Eye Serum: six-week dark-circle result
When dark circles make even a rested face look tired, choose NeoTight Eye Serum. Its lightweight eye-area treatment goes on before richer moisture, morning and evening.
In an independent study, NeoTight™ Eye Serum improved the appearance of under-eye dark circles by 38.10% at 6 weeks.
how to use it
When dark circles or puffiness lead, use NeoTight Eye Serum as the lightweight treatment morning and evening, before moisturizer. Independent graders followed 33 participants for six weeks. Review the result and timing together in the NeoTight Eye Serum Clinical.
the science
Expert graders scored visible dark circles and other eye-area concerns across six weeks, so this is an appearance assessment rather than an instrument reading. The study evaluated NeoTight Revitalizing Eye Serum. NeoTight™ Eye Serum is a lightweight, targeted eye-area treatment with SenePlex+®, including its two orchids, Calanthe discolor orchid stem cells and Orchis Mascula (Orchid) Flower Extract, plus Sodium Hyaluronate, for morning-and-evening use. NeoTight Eye Serum evidence record
C-Bright Dark Spot Corrector: visible brightness
For dark spots and old breakout marks that interrupt an even-looking complexion, reach for C-Bright Dark Spot Corrector. Stabilized 3-O-Ethyl Ascorbic Acid with Ferulic Acid brings brightness care to your treatment step.
At 8 weeks, 88% of subjects improved on the image-analyzed skin-brightness endpoint.
Apply it as directed before moisturizer and open the C-Bright Clinical.
how to use it
Choose C-Bright when dark spots, acne-scar marks, dullness, or uneven-looking tone lead. Apply it in the directed treatment position before moisturizer. Photograph your starting point and follow-up under matched light, angle, and exposure, and review the C-Bright Clinical beside your photos.
the science
In an independent study, C-Bright improved the appearance of skin brightness by 5.0% at 8 weeks.
Digital image analysis compared standardized facial photographs from 34 participants across eight weeks. It measured the complete C-Bright formula on brightness and also followed hyperpigmentation, dark acne-scar appearance, and tone evenness. C-Bright evidence record
EyeCrème: radiance, wrinkle, and comfort proof
The eye area is where a tired week often shows first. EyeCrème gives that thin, expressive area a richer AM/PM moisture step, with a cream format suited to softness and comfort.
After 8 weeks with EyeCrème, 87.10% showed measured radiance improvement and 64.52% showed a measured decrease in wrinkle appearance.
Apply EyeCrème after cleansing and before facial moisturizer, then open the EyeCrème Clinicals.
how to use it
Use EyeCrème as richer AM/PM eye moisture after cleansing and before facial moisturizer. Two studies of 31 participants cover different ground: expert grading and skin imaging give responder rates, while consumer feedback covers lines, smoothness, radiance, and a refreshed look. EyeLuminator follows as sheer morning makeup.
the science
An independent eight-week study of 31 participants used expert grading and Visioscan skin imaging against baseline. Responder rates record measured change; a separate 31-participant study records consumer feedback. EyeCrème is ophthalmologist-tested and safe for contact-lens wearers. Open EyeCrème Clinicals or its entry in SeneGence Clinicals.
What Eight Weeks of SenePlex+ Skincare Changed
For a morning-and-evening routine that works together, begin with Normal-to-Dry 3-in-1 Cleanser, DayTime Moisturizer and Evening Moisturizer. Their SenePlex+® includes yeast-and-kelp bioferment enzymes for a gently renewed look. At week 8, expert grading found a 23.60% mean improvement in visible radiance in the tested Normal-to-Dry three-product regimen.
Eight-week clinical evaluation and consumer agreement support SenePlex+ for visible skin quality.
Cleanse morning and evening. Follow with DayTime Moisturizer by day and Evening Moisturizer at night, then open the SenePlex+ Clinical.
how to use it
Use the three together as directed. Cleanse with Normal-to-Dry 3-in-1 Cleanser morning and evening, follow with DayTime Moisturizer by day and Evening Moisturizer at night, and explore the SenePlex+ Clinical beside your routine.
the science
For eight weeks, participants cleansed morning and evening with Normal-to-Dry 3-in-1 Cleanser, used DayTime Moisturizer by day and Evening Moisturizer at night. Instrumental measurements, clinical grading and consumer agreement followed the three-product SenePlex+ routine. Open the SenePlex+ evidence record for the full timeline.
Three Concerns, Three Serums, Three Studies
Hydration, the look of facial volume, and brightness can all make skin look fresher, but they are different wishes. SeneCell brings concentrated hydration. GLP Complex brings Ornithine HCl, Phospholipids and Glycolipids together for the look of facial volume, with Centella Asiatica Leaf Vesicles and Caprooyl Tetrapeptide-3 with Dextran completing the formula. C-Bright brings stabilized 3-O-Ethyl Ascorbic Acid with Ferulic Acid for visible brightness.
Their clinical checkpoints are SeneCell hydration at 24 hours, GLP facial-volume appearance at eight weeks, and C-Bright brightness at eight weeks. Choose one treatment after Climate Control and before moisturizer.
how to use it
Decide which change matters most to you, then compare texture, directions, and routine match before choosing one serum. Place it after Climate Control and before moisturizer. Open the matching report beside your choice: SeneCell Clinical, GLP Complex Clinical, or C-Bright Clinical.
the science
The three endpoints use different methods and periods because hydration, facial-volume appearance, and brightness are different properties. Each evidence record keeps the tested formula beside its own method. Choose by the visible goal rather than by a shared ingredient.
Eye-Area Layering Order: NeoTight, EyeCrème, Then EyeLuminator
Tired-looking eyes may want treatment, moisture, light, or all three. NeoTight Eye Serum brings the lightweight targeted treatment. EyeCrème brings richer moisture plus its eight-week radiance and wrinkle-appearance result. EyeLuminator uses mica and pigments for immediate optical brightness.
At the mirror, use NeoTight first, EyeCrème next, and EyeLuminator last. Compare the eye-area choices
how to use it
Layer by job: TREAT with NeoTight Eye Serum → MOISTURIZE with EyeCrème → BRIGHTEN with EyeLuminator. Apply the lightweight treatment morning and evening, follow with EyeCrème, keep both before facial moisturizer, and finish with EyeLuminator as sheer morning makeup.
the science
Vehicle and endpoint separate the three jobs. NeoTight™ Eye Serum is a lightweight treatment with SenePlex+® (both orchids, Calanthe Discolor (Ebine) Extract and Orchis Mascula (Orchid) Flower Extract, with yeast-and-kelp bioferments) and Sodium Hyaluronate. EyeCrème, rich in orchid stem cells, carries SenePlex+® with both orchids too, in a richer moisture cream with measured, consumer, and safety results of its own. EyeLuminator's mica and pigments create optical brightness. EyeCrème Clinicals
Study results at a glance
NeoTight® Rejuvenating Anti-Wrinkle Serum — one-hour and six-week study20 results
| Result | Kind of result | When it was measured |
|---|---|---|
| In an independent study, Rejuvenating Anti-Wrinkle Serum improved measured net skin elasticity by 7.65% one hour after a single application. | Measured result | baseline to 1 hour after a single application |
| One hour after a single application of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 12.05% average improvement in firmer-looking skin. | Expert assessment | 1 hour after a single application |
| At week 6, 84.38% of participants agreed that they liked how their skin felt immediately after applying Rejuvenating Anti-Wrinkle Serum. | Participant feedback | week-6 questionnaire about immediate application feel |
| After six weeks of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 24.53% average improvement in the appearance of crow’s feet. | Expert assessment | 6 weeks |
| After six weeks of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 13.64% average improvement in the appearance of upper-lip lines. | Expert assessment | 6 weeks |
Show 15 more results
| Result | Kind of result | When it was measured |
|---|---|---|
| After six weeks of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 7.14% average improvement in the appearance of nasolabial folds. | Expert assessment | 6 weeks |
| At week 6, 96.88% of participants agreed that Rejuvenating Anti-Wrinkle Serum hydrated their skin well. | Participant feedback | 6 weeks |
| At week 6, 87.50% of participants agreed that Rejuvenating Anti-Wrinkle Serum improved their skin's overall appearance. | Participant feedback | 6 weeks |
| At week 6, 84.38% of participants agreed that NeoTight® Rejuvenating Anti-Wrinkle Serum reduced the appearance of fine lines and wrinkles. | Participant feedback | 6 weeks |
| At week 6, 78.13% of participants agreed that NeoTight® Rejuvenating Anti-Wrinkle Serum reduced the appearance of crow's feet around the eyes. | Participant feedback | 6 weeks |
| At week 6, 62.50% of participants agreed that NeoTight® Rejuvenating Anti-Wrinkle Serum reduced the appearance of nasolabial folds. | Participant feedback | 6 weeks |
| At week 6, 71.88% of participants agreed that NeoTight® Rejuvenating Anti-Wrinkle Serum reduced the appearance of upper-lip lines. | Participant feedback | 6 weeks |
| At week 6, 75.00% of participants agreed that their face appeared more youthful after using Rejuvenating Anti-Wrinkle Serum. | Participant feedback | 6 weeks |
| At week 6, 75.00% of participants agreed that their skin felt firmer after using Rejuvenating Anti-Wrinkle Serum. | Participant feedback | 6 weeks |
| At week 6, 71.88% of participants agreed that their skin appeared tighter after using Rejuvenating Anti-Wrinkle Serum. | Participant feedback | 6 weeks |
| At week 6, 96.88% of participants agreed that their skin tolerated Rejuvenating Anti-Wrinkle Serum well without sensitivities. | Participant feedback | 6 weeks |
| At week 6, 84.38% of participants agreed that they liked the color, texture, smell, and feel of Rejuvenating Anti-Wrinkle Serum. | Participant feedback | 6 weeks |
| At week 6, 71.88% of participants agreed that Rejuvenating Anti-Wrinkle Serum absorbed well and did not feel greasy or tacky. | Participant feedback | 6 weeks |
| At week 6, 87.50% of participants agreed that they liked Rejuvenating Anti-Wrinkle Serum overall. | Participant feedback | 6 weeks |
| At week 6, 71.88% of participants agreed that they noticed a firmer-looking, more lifted appearance after applying Rejuvenating Anti-Wrinkle Serum. | Participant feedback | week-6 questionnaire about appearance after application |
See the full finding: NeoTight® Rejuvenating Anti-Wrinkle Serum — one-hour and six-week study · Open the study PDF
NeoTight™ Eye Serum — six-week study3 results
| Result | Kind of result | When it was measured |
|---|---|---|
| In an independent study, NeoTight™ Eye Serum improved the appearance of under-eye dark circles by 38.10% at 6 weeks. | Expert assessment | 6 weeks |
| In an independent study, NeoTight™ Eye Serum improved the appearance of under-eye puffiness or bags by 23.12% at 6 weeks. | Expert assessment | 6 weeks |
| In an independent study, NeoTight™ Eye Serum improved the appearance of peri-orbital fine lines and wrinkles by 8.82% at 6 weeks. | Expert assessment | 6 weeks |
See the full finding: NeoTight™ Eye Serum — six-week study · Open the study PDF
C-Bright Dark Spot Corrector — image-analysis study11 results
| Result | Kind of result | When it was measured |
|---|---|---|
| In an independent study, C-Bright improved the appearance of skin brightness by 2.3% at 4 weeks. | Measured result | 4 weeks |
| In an independent study, C-Bright improved the appearance of hyperpigmentation by 2.6% at 4 weeks. | Measured result | 4 weeks |
| Seventy-six percent of subjects in the C-Bright hyperpigmentation sub-panel improved at the measured endpoints. | Measured result | 4 and 8 weeks |
| At week 4, 76% of participants showed image-analyzed improvement in skin brightness with C-Bright Dark Spot Corrector. | Measured result | 4 weeks |
| In an independent study, C-Bright improved the appearance of skin brightness by 5.0% at 8 weeks. | Measured result | 8 weeks |
Show 6 more results
| Result | Kind of result | When it was measured |
|---|---|---|
| At 8 weeks, 88% of subjects improved on the image-analyzed skin-brightness endpoint. | Measured result | 8 weeks |
| In an independent study, C-Bright improved the appearance of hyperpigmentation by 2.5% at 8 weeks. | Measured result | 8 weeks |
| In an independent study, C-Bright improved the appearance of dark acne scars by 1.2% at 8 weeks. | Measured result | 8 weeks |
| In an independent study, C-Bright evened the appearance of skin tone by 0.3% at 8 weeks. | Measured result | 8 weeks |
| At week 8, 77% of participants in the dark-acne-scar sub-panel showed image-analyzed improvement in the appearance of dark acne scars with C-Bright Dark Spot Corrector. | Measured result | 8 weeks |
| At week 8, 85% of participants showed image-analyzed improvement in the L* skin-tone endpoint with C-Bright Dark Spot Corrector. | Measured result | 8 weeks |
See the full finding: C-Bright Dark Spot Corrector — image-analysis study · Open the study PDF
EyeCrème — eight-week clinical, consumer, and safety results9 results
| Result | Kind of result | When it was measured |
|---|---|---|
| In the separate eight-week consumer study of EyeCrème, 67.74% of participants agreed that the skin around their eyes immediately felt hydrated, and 64.52% agreed that their crow’s feet looked reduced. | Participant feedback | eight-week consumer study; immediate-feel and crow's-feet statements |
| After eight weeks with EyeCrème, 87.10% of participants showed measured improvement in skin radiance in the eye area. | Measured result | 8 weeks |
| After eight weeks with EyeCrème, 64.52% of participants showed a measured decrease in the appearance of wrinkles in the eye area. | Measured result | 8 weeks |
| At week 8 of the separate EyeCrème consumer study of 31 participants, 83.87% agreed that their lines and wrinkles appear diminished. | Participant feedback | 8 weeks |
| After eight weeks with EyeCrème, 80.65% of consumer-study participants agreed that their eye area looked more rested. | Participant feedback | 8 weeks |
Show 4 more results
| Result | Kind of result | When it was measured |
|---|---|---|
| After eight weeks with EyeCrème, 77.42% of consumer-study participants agreed that their eye area looked smoother and more awake. | Participant feedback | 8 weeks |
| After eight weeks with EyeCrème, 74.19% of consumer-study participants agreed that their eye area looked more radiant. | Participant feedback | 8 weeks |
| After eight weeks with EyeCrème, 70.97% of consumer-study participants agreed that their eye area looked refreshed and less crepey. | Participant feedback | 8 weeks |
| EyeCrème is ophthalmologist-tested and safe for contact-lens wearers. | Safety testing | during daily EyeCrème use |
See the full finding: EyeCrème — eight-week clinical, consumer, and safety results · Open the study PDF
SenePlex+ Normal-to-Dry regimen — eight-week skin quality17 results
| Result | Kind of result | When it was measured |
|---|---|---|
| The tested SenePlex+ regimen improved measured hydration by 49.99% immediately after application. | Measured result | immediate |
| The tested SenePlex+ regimen improved measured hydration by 12.5% at week 2. | Measured result | 2 weeks |
| The tested SenePlex+ regimen improved measured firmness by 7.06% at week 2 on the Cutometer R0 parameter, where a lower value indicates firmer skin. | Measured result | 2 weeks |
| The tested SenePlex+ regimen improved measured hydration by 12.0% at week 4. | Measured result | 4 weeks |
| The tested SenePlex+ regimen improved measured hydration by 28.62% at 8 weeks. | Measured result | 8 weeks |
Show 12 more results
| Result | Kind of result | When it was measured |
|---|---|---|
| The tested SenePlex+ regimen improved measured firmness by 6.59% at week 8 on the Cutometer R0 parameter, where a lower value indicates firmer skin. | Measured result | 8 weeks |
| In an independent eight-week study of 32 women using the SenePlex+® Normal-to-Dry regimen (3 in 1 Cleanser – Normal to Dry, DayTime Moisturizer – Normal to Dry and Evening Moisturizer – Normal to Dry), expert grading at week 8 found improved visible brightness, radiance, or luminosity in 96.88% of subjects. | Expert assessment | 8 weeks |
| At week 8, expert grading found improved visible firmness in 80.65% of subjects using the tested regimen. | Expert assessment | 8 weeks |
| At week 8, expert grading found improved visible texture or smoothness in 71.88% of subjects using the tested regimen. | Expert assessment | 8 weeks |
| At week 8, expert grading found improved visible tone evenness in 56.25% of subjects using the tested regimen. | Expert assessment | 8 weeks |
| At week 8, expert grading found improvement in the appearance of fine lines or wrinkles in 31.25% of subjects using the tested regimen. | Expert assessment | 8 weeks |
| At week 8, 100% of subjects agreed that skin felt more moisturized. | Participant feedback | 8 weeks |
| At week 8, 100% of subjects agreed that skin tone looked more supple. | Participant feedback | 8 weeks |
| At week 8, 100% of subjects agreed that skin texture felt smoother. | Participant feedback | 8 weeks |
| In an independent eight-week study of 32 women using the SenePlex+® Normal-to-Dry regimen (3 in 1 Cleanser – Normal to Dry, DayTime Moisturizer – Normal to Dry and Evening Moisturizer – Normal to Dry), 96.88% agreed at week 8 that their skin looked more luminous, radiant, or bright. | Participant feedback | 8 weeks |
| At week eight, 96.88% of participants said they would buy the Normal-to-Dry 3-in-1 Cleanser, DayTime Moisturizer, and Evening Moisturizer regimen. | Participant feedback | 8 weeks |
| At week 8, expert grading found a 23.60% mean improvement in visible radiance in the tested Normal-to-Dry three-product regimen. | Expert assessment | 8 weeks |
See the full finding: SenePlex+ Normal-to-Dry regimen — eight-week skin quality · Open the study PDF
SeneCell™ SenePlex+® StemCell Concentrate — hydration study11 results
| Result | Kind of result | When it was measured |
|---|---|---|
| In an independent eight-week study of 31 women ages 38–75, SeneCell™ SenePlex+® StemCell Concentrate improved measured skin hydration by a mean 73.9% immediately after application, assessed by a skin-moisture meter compared with baseline. | Measured result | immediate |
| All 31 participants showed measured improvement in skin hydration immediately after applying SeneCell. | Measured result | immediate |
| In an independent eight-week study of 31 women ages 38–75, SeneCell™ SenePlex+® StemCell Concentrate improved measured skin hydration by a mean 42.5% at 24 hours, assessed by a skin-moisture meter compared with baseline. | Measured result | 24 hours |
| At 24 hours, 81% of participants showed measured improvement in skin hydration after using SeneCell. | Measured result | 24 hours |
| In an independent eight-week study of 31 women ages 38–75, SeneCell™ SenePlex+® StemCell Concentrate improved measured skin hydration by a mean 32.5% at 48 hours, assessed by a skin-moisture meter compared with baseline. | Measured result | 48 hours |
Show 6 more results
| Result | Kind of result | When it was measured |
|---|---|---|
| At 48 hours, 81% of participants showed measured improvement in skin hydration after using SeneCell. | Measured result | 48 hours |
| In an independent eight-week study of 31 women ages 38–75, SeneCell™ SenePlex+® StemCell Concentrate improved measured skin hydration by a mean 22.1% at four weeks, assessed by a skin-moisture meter compared with baseline. | Measured result | 4 weeks |
| At 4 weeks, 74% of participants showed measured improvement in skin hydration after using SeneCell. | Measured result | 4 weeks |
| In an independent eight-week study of 31 women ages 38–75, SeneCell™ SenePlex+® StemCell Concentrate improved measured skin hydration by a mean 56.4% at eight weeks, assessed by a skin-moisture meter compared with baseline. | Measured result | 8 weeks |
| All 31 participants showed measured improvement in skin hydration after 8 weeks of using SeneCell. | Measured result | 8 weeks |
| No irritation was observed among the 31 participants during the eight-week SeneCell study. | Safety testing | 8-week study |
See the full finding: SeneCell™ SenePlex+® StemCell Concentrate — hydration study · Open the study PDF
GLP Complex™ with SenePlex+® and Exosomes — wrinkles and facial-volume study5 results
| Result | Kind of result | When it was measured |
|---|---|---|
| In an independent study of 31 participants measured by image analysis, GLP Complex™ with SenePlex+® and Exosomes reduced the appearance of deep wrinkles by 11.2% at four weeks. | Measured result | 4 weeks |
| All 31 participants showed image-analyzed improvement in deep-wrinkle appearance after four and eight weeks of using GLP Complex™ with SenePlex+® and Exosomes. | Measured result | 4 and 8 weeks |
| In an independent study, GLP Complex™ with SenePlex+® and Exosomes reduced the appearance of deep wrinkles by 23.4% at eight weeks. | Measured result | 8 weeks |
| In an independent study, GLP Complex™ with SenePlex+® and Exosomes improved the look of facial volume by 8.4% at eight weeks. | Measured result | 8 weeks |
| At eight weeks, 81% of participants showed image-analyzed improvement in the look of facial volume after using GLP Complex™ with SenePlex+® and Exosomes. | Measured result | 8 weeks |
See the full finding: GLP Complex™ with SenePlex+® and Exosomes — wrinkles and facial-volume study · Open the study PDF