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How SenePlex+ Connects Skincare and Makeup

SenePlex+® brings together biofermented yeast and kelp enzymes, two orchids, Calanthe Discolor (Ebine) Extract (the orchid stem cells) and Orchis Mascula (Orchid) Flower Extract, and a hydrating complex for a gently renewed, resilient-looking, comfortable complexion. SeneGence carries it from your first skin-care layer into cream color.

How does SenePlex+® connect skincare and color?

Joni Rogers-Kante, founder of SeneGence, on the volcanic ash plain of Mount Yasur, Tanna, Vanuatu, summer 2000.
Joni Rogers-Kante, founder of SeneGence, on the volcanic ash plain of Mount Yasur, Tanna, Vanuatu, summer 2000.

SenePlex+® is SeneGence’s foundational proprietary anti-aging complex, at work in most of our products. Our extremophile technology is made with extracts and cells that survive in extreme environments.

You can meet SenePlex+® in water-light Climate Control, concentrated SeneCell™, and cream color with BlushSense®. SeneGence also names SenePlex+® in ShadowSense®, alongside the conditioning care in its crème-to-powder eye color. Each texture gives care a different place in your day. Evening Moisturizer - Normal to Dry, the cream at the center of the SenePlex+® renewal studies, carries Saccharomyces Cerevisiae (Yeast) Extract and Laminaria Digitata (Kelp) Extract.

The orchid of the Mount Yasur caldera inspired SenePlex+®, which carries two orchids: Calanthe Discolor (Ebine) Extract, the orchid stem cells, and Orchis Mascula (Orchid) Flower Extract. Read the orchid legend.

how to use it

Compare Climate Control's water-light preparation with SeneCell™ as the final treatment step, then swatch BlushSense® and ShadowSense®, both made with SenePlex+® and conditioning care, on the back of your hand to see how skin-care thinking moves into cream color.

the science

It combines Calanthe Discolor (Ebine) Extract orchid stem cells and Orchis Mascula (Orchid) Flower Extract; biofermented Saccharomyces Cerevisiae (Yeast) Extract and Laminaria Digitata (Kelp) Extract; Hydrolyzed Opuntia Ficus-Indica (Prickly Pear) Flower Extract; Sodium Hyaluronate, a form of hyaluronic acid; Glucosamine HCl; Urea; Panthenol (vitamin B5); and vitamin E (Tocopheryl Acetate or Tocopherol). SenePlex+® promotes collagen, protects against stressors, brightens the complexion and accelerates skin renewal, while deeply moisturizing skin.

The bioferment family uses biofermented Saccharomyces cerevisiae and Laminaria digitata enzymes. The orchid family is two orchids: Calanthe Discolor (Ebine) Extract, the orchid stem cells, and Orchis Mascula (Orchid) Flower Extract. The hydration family brings together Hydrolyzed Opuntia Ficus-Indica (Prickly Pear) Flower Extract, Sodium Hyaluronate, Panthenol, and Glucosamine.

Vehicle, concentration, contact time, and neighboring ingredients vary among formulas, which is why each product’s own directions and results guide how you use it.

Evening Moisturizer - Normal to Dry was the evening step of the tested three-product Normal-to-Dry regimen, which raised measured hydration from the first use and improved firmness, radiance and smoothness through week eight: see the SenePlex+ regimen results. Explore the ingredients in SenePlex+.

SeneCell: Concentrated Hydration Before Moisturizer

SeneCell™ by SeneGence: a cream concentrate bottle with a blue orchid-decorated cap,  SenePlex+® StemCell Concentrate.
SeneCell™ SenePlex+® StemCell Concentrate — the product shown.

When skin feels tight or loses its fresh, cushioned look through the day, SeneCell™ gives concentrated hydration its own treatment step. SeneCell™ SenePlex+® StemCell Concentrate is the hydration-rich final treatment after GLP Complex™ with SenePlex+® and Exosomes in the Triple Cell Renewal Trio. Smooth it over face and neck and let it settle before moisturizer, and skin keeps that cushioned, hydrated feel.

how to use it

Apply the directed two pumps after Climate Control and GLP Complex™ when using the Trio. Smooth over face and neck, let the concentrate settle, then finish with the moisturizer that fits your skin and time of day. SeneCell.

the science

SeneCell™ carries SenePlex+® in a lightweight concentrate with Sodium Hyaluronate Crosspolymer and other humectant support for water binding, plus Caprooyl Tetrapeptide-3 with Dextran for smoother-looking skin and Calanthe discolor orchid stem cells for cosmetic lifting support. The vehicle makes it a treatment layer rather than the cream that closes the routine.

Evening Moisturizer: Rich Comfort After Treatment

Evening Moisturizer - Normal to Dry by SeneGence: a purple jar with an orchid-engraved gold lid.
Evening Moisturizer - Normal to Dry — the product shown.

When Normal-to-Dry skin wants a richer finish at night, Evening Moisturizer - Normal to Dry closes the routine with softness, comfort, and moisture after treatment. Its cream vehicle answers a different need from water-light Climate Control or concentrated SeneCell™.

how to use it

After the chosen treatment has settled, apply the directed quarter-size amount over face and neck, massage, then press and roll with the fingertips. Choose Evening Moisturizer - Normal to Dry when that matches your skin at night. Evening Moisturizer - Normal to Dry.

the science

The cream combines humectant hydration from Glycerin, Sodium Hyaluronate, and Panthenol with emollient and lipid support from Carthamus Tinctorius (Safflower) Seed Oil, Canarium Indicum (Nangai) Seed Oil, Butyrospermum Parkii (Shea) Butter, and Rosa Canina (Rose Hip) Seed Oil, which helps with the appearance of photo-aging. Its product page highlights Ganoderma Lucidum (Mushroom) Stem Extract for a youthful lifted-look job and Garcinia Mangostana (Mangosteen) Fruit Extract for antioxidant protection against skin-damaging free radicals. The separate Nangai Oil formula—not Evening Moisturizer—owns the four-part Jojoba Oil/Macadamia Seed Oil Esters, Squalene, Phytosteryl Macadamiate, and Phytosterols skin-lipid-mimetic blend. Compare the Normal-to-Dry day and evening formulas and inspect Nangai Oil's botanically sourced skin-lipid mimetic. The richer cream vehicle makes Evening Moisturizer the final facial layer after treatment and after Nangai Oil, the condition-led lipid-optimization step when skin feels dry, tight, or depleted.

SenePlex+ and Conditioning Care in BlushSense and ShadowSense

BlushSense® Cream Blush by SeneGence: a clear tube of deep berry-red cream blush with a white collar and an orchid-engraved gold cap.
BlushSense Cream Blush in Burnished Berry.

After skincare has settled, BlushSense adds blendable, hydrating cheek color with a long-lasting, water-resistant finish. ShadowSense® answers the eye-color job with highly pigmented crème-to-powder color that sets to waterproof, fade-resistant, crease-free wear. BlushSense and ShadowSense® both carry SenePlex+®; their conditioning ingredients bring skin-care thinking into both, while each keeps its own finish: a blendable, water-resistant flush on the cheek and a set, crease-free sweep of color on the lid.

how to use it

Tap a small amount of BlushSense onto the cheek and blend before it sets. Apply ShadowSense® to one eye zone at a time, blend promptly with a fingertip or brush, then allow one minute to dry. Then compare cheek and eye in the mirror as two uses of cream texture.

the science

BlushSense combines an oil-free cream-color vehicle with SenePlex+®, Sodium Hyaluronate, vitamins, and Aloe for blendable color plus hydrating care. ShadowSense® Eyeshadow is the current US blendable crème-to-powder eye color for highly pigmented matte-to-shimmer looks with waterproof, fade-resistant, soft powdery crease-free wear, built on Isododecane and Trimethylsiloxysilicate with Glucosamine HCl and Tocopheryl Acetate. ShadowSense® carries SenePlex+® for care that helps reduce visible signs of aging; most shades include Orchis Mascula (Orchid) Flower Extract, Laminaria Digitata (Kelp) Extract and Saccharomyces Cerevisiae (Yeast) Extract, and many add Calanthe Discolor (Ebine) Extract. Each shade’s label shows its own. Isododecane and Trimethylsiloxysilicate build ShadowSense's set film, while its conditioning ingredients sit beside that performance system. BlushSense or ShadowSense.

What Eight Weeks of the Normal-to-Dry Regimen Found

A matched routine can answer more than one beauty concern when its cleanser and day-and-night moisturizers are used together. The SenePlex+® Normal-to-Dry skincare regimen increased hydration after the first use and, by Week 8, improved firmness, radiance, smoothness, tone evenness and line appearance. See the SenePlex+ Normal-to-Dry Regimen Clinical.

how to use it

Use the tested 3 in 1 Cleanser - Normal to Dry, DayTime Moisturizer - Normal to Dry, and Evening Moisturizer - Normal to Dry together as directed. Record a baseline under consistent light and reassess comfort, hydration, firmness, radiance, smoothness, tone evenness, and line appearance at comparable checkpoints.

the science

The eight-week independent study combined Corneometer hydration, Cutometer firmness, expert grading of visible skin qualities, and participant questionnaires. It followed the matched Normal-to-Dry three-product regimen used together: moisture arrived immediately, and skin looked firmer, smoother and more radiant with continued use. Open the complete regimen report.

Water-Light Hydration Before Treatment

Climate Control by SeneGence: a blue bottle with a dark blue orchid-decorated cap.
Climate Control — the product shown.

Climate Control is a lightweight hydrating gel essence used after cleansing and before treatment serum and moisturizer. Its sugar complex and Sodium Hyaluronate help bind water at the surface, giving dry or tight-feeling skin a more comfortable starting point. SenePlex+® joins them, so your first layer already carries yeast-and-kelp bioferment enzymes, two orchids and hydration.

how to use it

Compare Climate Control with a cream moisturizer on the back of the hand. The gel essence feels water-light; the moisturizer supplies the richer finish. See molecular-weight layering for the broader texture-and-order lesson.

If you want the fuller SenePlex+ routine, Climate Control is the water-light hydration layer after cleansing and before your treatment serum.

the science

Climate Control carries SenePlex+® and sits comfortably beside the other SenePlex+® formulas in your routine, each with its own feel: the gel essence prepares, the treatment answers your concern and the moisturizer supplies the finish. The technology links the steps, and each bottle keeps its own texture and purpose.

Choose the Formula by Its Beauty Job

Choose Microbiome Boosting Serum for lightweight hydration, DayTime Moisturizer – Dry for its daytime firming care, Evening Moisturizer – Dry for night-time texture and radiance, or Microbiome Restorative Evening Moisturizer for richer barrier comfort overnight. Nangai Oil brings lipid support and softness when skin feels dry, tight or depleted; Climate Control prepares with water-light hydration after cleansing and before treatment.

how to use it

Start with your daypart, texture, and beauty goal, then find the exact product name before comparing formulas. The two Dry moisturizers keep separate peptide jobs; the Microbiome evening formula keeps its own barrier-lipid job; Nangai Oil remains a separate oil step. Climate Control stays in its preparation position before treatment rather than replacing the serum or moisturizer.

the science

Choose by the beauty job and texture you want. Microbiome Boosting Serum is the lightweight morning-and-evening hydration path: Lactobacillus Ferment conditions dry-looking skin for a supple feel, while Sphingomonas Ferment Extract is valued in cosmetic science for the silky texture it can lend a formula; Sodium Hyaluronate, Hyaluronic Acid, and Sodium Hyaluronate Crosspolymer bring the water-binding care. Explore the serum's ferment functions. DayTime Moisturizer - Dry keeps Bis(Tripeptide-1) Copper Acetate with its firmer-looking daytime job, while Evening Moisturizer - Dry keeps Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76 with its texture-and-radiance night job. Microbiome Restorative Evening Moisturizer pairs Ceramide NP and Cholesterol for richer barrier comfort overnight. Nangai Oil is the triglyceride-rich Canarium indicum seed-oil path for barrier support, moisture retention, and softness. For the SenePlex+® path, Climate Control is the water-light preparation layer after cleansing and before treatment serum.

Read the proof beside each exact formula: Microbiome Boosting Serum formula and hydration source, DayTime Moisturizer - Dry copper-peptide source, Evening Moisturizer - Dry texture-and-radiance peptide source, Microbiome Restorative Evening Moisturizer barrier-lipid source, and Nangai Oil formula source. SenePlex+® technology source explains the shared bioferment, orchid, and hydration architecture; Climate Control formula and preparation source keeps that technology in its water-light gel-essence vehicle and directed routine position. Start with the ingredient family, then let the finished formula show you what it will do for your skin.

Study results at a glance

SenePlex+ Normal-to-Dry regimen — eight-week skin quality17 results
SenePlex+ Normal-to-Dry regimen — eight-week skin quality
ResultKind of resultWhen it was measured
The tested SenePlex+ regimen improved measured hydration by 49.99% immediately after application.Measured resultimmediate
The tested SenePlex+ regimen improved measured hydration by 12.5% at week 2.Measured result2 weeks
The tested SenePlex+ regimen improved measured firmness by 7.06% at week 2 on the Cutometer R0 parameter, where a lower value indicates firmer skin.Measured result2 weeks
The tested SenePlex+ regimen improved measured hydration by 12.0% at week 4.Measured result4 weeks
The tested SenePlex+ regimen improved measured hydration by 28.62% at 8 weeks.Measured result8 weeks
Show 12 more results
SenePlex+ Normal-to-Dry regimen — eight-week skin quality, more results
ResultKind of resultWhen it was measured
The tested SenePlex+ regimen improved measured firmness by 6.59% at week 8 on the Cutometer R0 parameter, where a lower value indicates firmer skin.Measured result8 weeks
In an independent eight-week study of 32 women using the SenePlex+® Normal-to-Dry regimen (3 in 1 Cleanser – Normal to Dry, DayTime Moisturizer – Normal to Dry and Evening Moisturizer – Normal to Dry), expert grading at week 8 found improved visible brightness, radiance, or luminosity in 96.88% of subjects.Expert assessment8 weeks
At week 8, expert grading found improved visible firmness in 80.65% of subjects using the tested regimen.Expert assessment8 weeks
At week 8, expert grading found improved visible texture or smoothness in 71.88% of subjects using the tested regimen.Expert assessment8 weeks
At week 8, expert grading found improved visible tone evenness in 56.25% of subjects using the tested regimen.Expert assessment8 weeks
At week 8, expert grading found improvement in the appearance of fine lines or wrinkles in 31.25% of subjects using the tested regimen.Expert assessment8 weeks
At week 8, 100% of subjects agreed that skin felt more moisturized.Participant feedback8 weeks
At week 8, 100% of subjects agreed that skin tone looked more supple.Participant feedback8 weeks
At week 8, 100% of subjects agreed that skin texture felt smoother.Participant feedback8 weeks
In an independent eight-week study of 32 women using the SenePlex+® Normal-to-Dry regimen (3 in 1 Cleanser – Normal to Dry, DayTime Moisturizer – Normal to Dry and Evening Moisturizer – Normal to Dry), 96.88% agreed at week 8 that their skin looked more luminous, radiant, or bright.Participant feedback8 weeks
At week eight, 96.88% of participants said they would buy the Normal-to-Dry 3-in-1 Cleanser, DayTime Moisturizer, and Evening Moisturizer regimen.Participant feedback8 weeks
At week 8, expert grading found a 23.60% mean improvement in visible radiance in the tested Normal-to-Dry three-product regimen.Expert assessment8 weeks
Who took part
34 enrolled; 32 completed; women ages 25–70
How it was evaluated
Eight-week dermatologist-supervised monadic study; Corneometer and Cutometer measurements, expert grading, and consumer questionnaire
Statistical context
Hydration significant at every measured timepoint: p<0.001 immediately and at Week 8; p=0.005 at Week 2; p=0.003 at Week 4; expert-grading endpoints statistically significant as reported

See the full finding: SenePlex+ Normal-to-Dry regimen — eight-week skin quality · Open the study PDF

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