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Science & Ingredients

SenePlex+ Ingredients

SenePlex+ combines biofermented yeast and kelp enzymes; two orchids, Calanthe Discolor (Ebine) Extract (the orchid stem cells) and Orchis Mascula (Orchid) Flower Extract; and prickly pear with humectants, for renewal, resilience, and hydration. It is SeneGence's proprietary, catalogue-wide anti-aging technology wherever it appears.

How the SenePlex+® Ingredients Work Together

SenePlex+® is SeneGence’s foundational proprietary anti-aging complex, at work in most of our products. Our extremophile technology is made with extracts and cells that survive in extreme environments.

SenePlex+® brings together biofermented yeast and kelp enzymes for a gently renewed look; two orchids, Calanthe Discolor (Ebine) Extract (the orchid stem cells) and Orchis Mascula (Orchid) Flower Extract, for resilient-looking skin; and prickly pear with humectants for moisture and comfort. One name, three distinct reasons it is there. Explore the SenePlex+ bioferments and their roles.

All three families meet in Microbiome Boosting Serum, where SenePlex+® orchid stem cells, yeast-and-kelp bioferments and prickly pear with hyaluronic acid join its prebiotic hydration. Explore Microbiome Boosting Serum.

how to use it

Set two SenePlex+ formulas side by side — Climate Control for the yeast-and-kelp bioferments with prickly pear hydration, and SeneCell for orchid stem cells and a resilient-looking finish — then choose by your goal, the texture you prefer and where it sits in your routine.

the science

SenePlex+® is SeneGence’s foundational proprietary anti-aging complex, at work in most of our products. Our extremophile technology is made with extracts and cells that survive in extreme environments. Its ingredient family combines Calanthe Discolor (Ebine) Extract orchid stem cells and Orchis Mascula (Orchid) Flower Extract; biofermented Saccharomyces Cerevisiae (Yeast) Extract and Laminaria Digitata (Kelp) Extract; Hydrolyzed Opuntia Ficus-Indica (Prickly Pear) Flower Extract; Sodium Hyaluronate, a form of hyaluronic acid; Glucosamine HCl; Urea; Panthenol (vitamin B5); and vitamin E (Tocopheryl Acetate or Tocopherol). The bioferments bring a gently renewed look, the two orchids resilient-looking skin, and prickly pear with humectants moisture and comfort. SenePlex+® promotes collagen, protects against stressors, brightens the complexion and accelerates skin renewal, while deeply moisturizing skin. On Joni Rogers-Kante’s search for extremophile organisms in Vanuatu, the orchid of the Mount Yasur caldera inspired SenePlex+®. Each product's complete formula, texture, directions, and finished-product evidence decide what you can expect from it. See everything inside SenePlex+®.

What do the yeast and kelp bioferments in SenePlex+ do?

Evening Moisturizer - Normal to Dry by SeneGence: a purple jar with an orchid-engraved gold lid.
Evening Moisturizer - Normal to Dry — the product shown.

A gently renewed look begins at the surface. Within SenePlex+®, biofermented yeast and kelp enzymes support that fresh, refined look without physical scrubbing. Evening Moisturizer – Normal to Dry gives Normal-to-Dry skin a richer, softer, more cushioned finish after treatment at night.

how to use it

After cleansing and treatment, use Evening Moisturizer – Normal to Dry as the richer final cream when it matches your skin. Climate Control supplies water-light preparation before treatment. Explore the directed Normal-to-Dry routine.

the science

SenePlex+® pairs biofermented yeast and kelp enzymes for gentle-looking surface renewal. Today’s Evening Moisturizer – Normal to Dry carries Saccharomyces Cerevisiae (Yeast) Extract and Laminaria Digitata (Kelp) Extract. It was the evening cream in the SenePlex+ regimen and surface-renewal studies. Read the Normal-to-Dry regimen results, the Evening Moisturizer surface-renewal study and the bioferments’ ingredient roles.

Why Orchid Stem Cells Belong in Eye-Area Care

NeoTight™ Eye Serum by SeneGence: a small pale blue-and-white eye-serum bottle with a blue orchid-decorated cap.
NeoTight™ Eye Serum — the product shown.

A more lifted-looking eye area can make the whole face look fresher.

Calanthe discolor orchid stem cells are selected for cosmetic lifting support and a more lifted-looking eye-area appearance. Because Calanthe Discolor (Ebine) Extract, the orchid stem cells, is one of SenePlex+®’s two orchids, you'll find its orchid stem cells in SeneCell™ SenePlex+® StemCell Concentrate and, around the eyes, in both NeoTight™ Eye Serum and EyeCrème. Choose SeneCell for concentrated hydration and visible-resilience care, or NeoTight Eye Serum for targeted eye-area firmness, brightness, smoothness, dark-circle, bag, wrinkle, and puffiness care. When the eye area wants richer morning-and-evening moisture, choose EyeCrème.

how to use it

For eye-area firmness, brightness, smoothness, dark circles, bags, wrinkles, or puffiness, choose NeoTight™ Eye Serum; gently pat it around the eyes, including eyelids, morning and evening. For richer eye-area moisture, choose EyeCrème and stipple it around the eye area morning and evening, after cleansing and before moisturizer. For concentrated hydration and visible resilience, choose SeneCell™ SenePlex+® StemCell Concentrate; in the Triple Cell Renewal Trio, apply two pumps after GLP Complex™ and before moisturizer. All three current formulas carry the orchid stem cells, declared on the label as Calanthe Discolor (Ebine) Extract, and each keeps its own job and directions.

the science

The ingredient’s maker reports a 7.6% eyelid-lift appearance result after 56 days with its Calanthe Discolor-derived material, in a study of 26 women aged 40–65. The material’s eyelid and jawline effects were assessed in two in-vivo studies in women, run separately from SeneGence’s own clinical studies.

The 56-day eyelid result, and a separate jawline result, belong to the Calanthe Discolor-derived material itself, studied in women in two in-vivo studies run separately from SeneGence's own clinical studies. SeneCell™ SenePlex+® StemCell Concentrate, NeoTight™ Eye Serum and EyeCrème each declare SenePlex+®’s two orchids, Calanthe Discolor (Ebine) Extract and Orchis Mascula (Orchid) Flower Extract, in their own current formulas. Open the orchid material's 56-day eyelid-lift study

How do prickly pear and Sodium Hyaluronate add hydration?

Climate Control by SeneGence: a blue bottle with a dark blue orchid-decorated cap.
Climate Control — the product shown.

Skin that feels tight by mid-afternoon and makeup that catches on dry-looking patches are the same complaint.

Prickly pear with Sodium Hyaluronate, Panthenol, and Glucosamine gives Climate Control soft, comfortable hydration in a lightweight layer used before treatment.

how to use it

For hydration, pump ready-to-use Climate Control onto the back of your hand after cleansing and palette it over face and neck, before treatment and moisturizer. As the hydration primer for the SeneGence Solutions that follow, it helps set up the skin barrier for their serum benefits, which is welcome when skin feels tight or makeup catches. Compare its slip with a richer moisturizer and you can feel why preparing and sealing are two different jobs. If the next layer drags, compare settling, pressure, and the adjacent formula.

the science

Hydrolyzed Opuntia Ficus-Indica (Prickly Pear) Flower Extract, Sodium Hyaluronate, Panthenol, and Glucosamine form the hydration family. Sodium Hyaluronate binds water at the surface, while Panthenol and Glucosamine condition and bind water. This family shapes hydration and feel; biofermented yeast and kelp enzymes support a gently renewed look, while the two orchids, Calanthe Discolor (Ebine) Extract and Orchis Mascula (Orchid) Flower Extract, support resilient-looking skin. See how the three roles meet inside SenePlex+®.

How SenePlex+ Appears Across Different Formula Jobs

SenePlex+® brings anti-aging care into skincare and cream color, with a different texture and purpose in each formula.

Climate Control prepares, SeneCell treats, and BlushSense carries pigment with SenePlex+® inside it. SeneGence also names SenePlex+® in ShadowSense®, alongside the conditioning ingredients in its eye-color finish. Choose by the job you need done tonight rather than by the name you recognize.

how to use it

Compare Climate Control's slip, SeneCell's texture, BlushSense placement, and ShadowSense's working window zone by zone to see where each fits in your sequence. Continue to How SenePlex+ Connects Skincare and Makeup or the SenePlex+ Clinical. After cleansing, pump Climate Control onto the back of your hand and palette it over face and neck as your hydration primer before the chosen treatment.

the science

A shared ingredient architecture can move through cleansers, gel essences, treatment serums, emulsions, and color cosmetics, but the delivery system changes with each vehicle. Rheology, contact time, companion ingredients, application amount, and routine order govern exposure and sensory performance. Formula-specific evidence therefore stays more informative than assuming one uniform effect across the catalogue.

Study results at a glance

SenePlex+ Normal-to-Dry regimen — eight-week skin quality17 results
SenePlex+ Normal-to-Dry regimen — eight-week skin quality
ResultKind of resultWhen it was measured
The tested SenePlex+ regimen improved measured hydration by 49.99% immediately after application.Measured resultimmediate
The tested SenePlex+ regimen improved measured hydration by 12.5% at week 2.Measured result2 weeks
The tested SenePlex+ regimen improved measured firmness by 7.06% at week 2 on the Cutometer R0 parameter, where a lower value indicates firmer skin.Measured result2 weeks
The tested SenePlex+ regimen improved measured hydration by 12.0% at week 4.Measured result4 weeks
The tested SenePlex+ regimen improved measured hydration by 28.62% at 8 weeks.Measured result8 weeks
Show 12 more results
SenePlex+ Normal-to-Dry regimen — eight-week skin quality, more results
ResultKind of resultWhen it was measured
The tested SenePlex+ regimen improved measured firmness by 6.59% at week 8 on the Cutometer R0 parameter, where a lower value indicates firmer skin.Measured result8 weeks
In an independent eight-week study of 32 women using the SenePlex+® Normal-to-Dry regimen (3 in 1 Cleanser – Normal to Dry, DayTime Moisturizer – Normal to Dry and Evening Moisturizer – Normal to Dry), expert grading at week 8 found improved visible brightness, radiance, or luminosity in 96.88% of subjects.Expert assessment8 weeks
At week 8, expert grading found improved visible firmness in 80.65% of subjects using the tested regimen.Expert assessment8 weeks
At week 8, expert grading found improved visible texture or smoothness in 71.88% of subjects using the tested regimen.Expert assessment8 weeks
At week 8, expert grading found improved visible tone evenness in 56.25% of subjects using the tested regimen.Expert assessment8 weeks
At week 8, expert grading found improvement in the appearance of fine lines or wrinkles in 31.25% of subjects using the tested regimen.Expert assessment8 weeks
At week 8, 100% of subjects agreed that skin felt more moisturized.Participant feedback8 weeks
At week 8, 100% of subjects agreed that skin tone looked more supple.Participant feedback8 weeks
At week 8, 100% of subjects agreed that skin texture felt smoother.Participant feedback8 weeks
In an independent eight-week study of 32 women using the SenePlex+® Normal-to-Dry regimen (3 in 1 Cleanser – Normal to Dry, DayTime Moisturizer – Normal to Dry and Evening Moisturizer – Normal to Dry), 96.88% agreed at week 8 that their skin looked more luminous, radiant, or bright.Participant feedback8 weeks
At week eight, 96.88% of participants said they would buy the Normal-to-Dry 3-in-1 Cleanser, DayTime Moisturizer, and Evening Moisturizer regimen.Participant feedback8 weeks
At week 8, expert grading found a 23.60% mean improvement in visible radiance in the tested Normal-to-Dry three-product regimen.Expert assessment8 weeks
Who took part
34 enrolled; 32 completed; women ages 25–70
How it was evaluated
Eight-week dermatologist-supervised monadic study; Corneometer and Cutometer measurements, expert grading, and consumer questionnaire
Statistical context
Hydration significant at every measured timepoint: p<0.001 immediately and at Week 8; p=0.005 at Week 2; p=0.003 at Week 4; expert-grading endpoints statistically significant as reported

See the full finding: SenePlex+ Normal-to-Dry regimen — eight-week skin quality · Open the study PDF

SenePlex+ Evening Moisturizer Normal to Dry — surface-renewal study8 results
SenePlex+ Evening Moisturizer Normal to Dry — surface-renewal study
ResultKind of resultWhen it was measured
In a 20-day independent clinical study of 33 women ages 19–65, measured by expert clinical grading compared with baseline, Evening Moisturizer – Normal to Dry with SenePlex+® and orchid stem cells achieved 100% cell renewal in 18 days, against a typical skin-renewal cycle of 28 or more days.Measured result18 days; 20-day study
In a 20-day independent clinical study of 33 women ages 19–65, measured by expert clinical grading compared with baseline, Evening Moisturizer – Normal to Dry with SenePlex+® and orchid stem cells accelerated skin cell renewal by 35.7%.Measured result20-day study
The treated SenePlex+ formula site showed 49% greater visible surface-cell turnover than the untreated control site at day 13.Measured result20-day study; day-13 endpoint
The treated SenePlex+ formula site showed 80% greater visible surface-cell turnover than the untreated control site at day 16.Measured result20-day study; day-16 endpoint
The treated SenePlex+ formula site showed 94% greater visible surface-cell turnover than the untreated control site at day 17.Measured result20-day study; day-17 endpoint
Show 3 more results
SenePlex+ Evening Moisturizer Normal to Dry — surface-renewal study, more results
ResultKind of resultWhen it was measured
In an independent 20-day study, Evening Moisturizer – Normal to Dry with SenePlex+® showed up to 100% greater visible surface-cell turnover than untreated skin by day 18.Measured result20-day study; day-18 endpoint
In the independent 20-day study of Evening Moisturizer – Normal to Dry with SenePlex+® in 33 women ages 19–65, assessed by dansyl-chloride scoring, mean time to full visible surface turnover was 15.5 ± 0.4 days at the treated site versus 18.0 ± 0.4 days at the untreated control site.Measured result20-day study
At day 18, mean residual surface-stain intensity was 0.00 at the treated site versus 0.18 at the untreated control site; lower values indicate faster clearance.Measured result20-day study; day-18 endpoint
Who took part
34 enrolled; 33 completed
How it was evaluated
Dansyl-chloride visual scoring of treated and untreated sites on the same subjects
Statistical context
Significant versus control on days 2–18; headline and mean-time comparisons p<0.001

See the full finding: SenePlex+ Evening Moisturizer Normal to Dry — surface-renewal study · Open the study PDF

Calanthe discolor orchid stem cells — 56-day eyelid-lift appearance1 result
Calanthe discolor orchid stem cells — 56-day eyelid-lift appearance
ResultKind of resultWhen it was measured
The ingredient’s maker reports a 7.6% eyelid-lift appearance result after 56 days with its Calanthe Discolor-derived material, in a study of 26 women aged 40–65. The material’s eyelid and jawline effects were assessed in two in-vivo studies in women, run separately from SeneGence’s own clinical studies.Ingredient study56 days
Who took part
26 women aged 40–65
How it was evaluated
Manufacturer-reported in-vivo eyelid-lifting study; separate 28-day jawline study
Statistical context
The 7.6% figure is the eyelid-lift appearance change the ingredient’s maker reports for its tested material at 56 days; its jawline effect comes from a separate 28-day study.

See the full finding: Calanthe discolor orchid stem cells — 56-day eyelid-lift appearance

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