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Innovation for beautiful skin and long-wear color.

Science & Ingredients

Find the ingredients and technologies that make your routine feel considered—from comfortable morning hydration to color that stays with you and the care you return to at night.

Start with what you want to see or feel. Then meet the formula, learn how to use it, and open the evidence behind it.

GLP Complex serum bottle on blue water, labeled Glow Lipids Peptides with SenePlex+ and Exosomes
GLP Complex™ with SenePlex+® and Exosomes.

5 guides · about 41 minutes

Build your day-to-night routine

SeneGence connects morning defense, long-wear color-as-skincare, and evening care in one 24-hour beauty philosophy.

Long-wear color is part of that care, not a pause from it. SenePlex+® carries from your morning skincare into our foundations and shadows, blush and highlighter, so the color you wear through the day brings skincare ingredients with it.

  1. Morning · Prep

    A water-light start for thirsty skin

    A blue bottle with a dark blue orchid-decorated cap, Climate Control.

    Pump Climate Control onto the back of your hand and palette it over cleansed face and neck for lightweight hydration before serums. This hydration primer brings together a nature-derived sugar complex, SenePlex+®, Glucosamine HCl and Sodium Hyaluronate to help prepare the skin barrier for the serum benefits that follow. Use it before your chosen treatment and moisturizer.

  2. Morning and evening · Treat

    Choose your treatment

    A cream concentrate bottle with a blue orchid-decorated cap, SeneCell™ SenePlex+® StemCell Concentrate.A pale blue bottle with a silver-colored cap and circular detail, C-Bright Dark Spot Corrector.A pale blue-and-white serum bottle with a blue orchid-decorated cap, NeoTight® Rejuvenating Anti-Wrinkle Serum.

    For the complete Triple Cell Renewal Trio, follow Climate Control with GLP Complex™ and then SeneCell™. Finish the treatment phase with the moisturizer suited to your skin and the time of day.

    Add a targeted treatment where you want extra care: C-Bright Dark Spot Corrector for brighter, more even-looking tone, NeoTight™ Eye Serum or EyeCrème for the eye area, and NeoTight® Rejuvenating Anti-Wrinkle Serum for softer-looking expression lines.

  3. Morning and evening · Moisturize

    Moisture made for your skin type

    Choose the DayTime and Evening Moisturizers for your skin type: Dry, Normal to Dry or Normal to Oily. All six share the two-peptide tone pair for more even-looking tone, and each brings its own signature ingredients. When skin feels dry, tight or depleted, smooth on Nangai Oil after your treatments and before moisturizer.

    Following the Microbiome Collection instead? Defense Daytime Moisturizer SPF 15 brings morning moisture with broad-spectrum SPF 15, and Restorative Evening Moisturizer takes the night step.

  4. Morning · Protect

    Finish morning skincare with sunscreen

    Make Microbiome Defense Daytime Moisturizer SPF 15 the last step of your morning skincare, smoothed on generously and evenly 15 minutes before sun exposure and reapplied at least every 2 hours. Microbiome Defense Daytime Moisturizer SPF 15 gives broad-spectrum UVA/UVB protection with Zinc Oxide 6% and Octisalate 5%. The same formula doubles as your daytime moisture step.

  5. Morning · Prime and base

    Prime and perfect your base

    Smooth on Glowify® Microbiome Serum Primer for a soft-focus glow, or MakeSense® Silk Primer & Pore Minimizer for a smoother-looking, more matte base. Blend MakeSense® Original Foundation, made with SenePlex+® and Adapting Pigment Technology, then touch MakeSense® Pearlizer onto the high points of your face.

  6. Morning · Cheek and eye color

    Cheek and eye color, with skincare inside

    BlushSense® Cream Blush and ShadowSense® Eyeshadow both carry SenePlex+®. Blend BlushSense over foundation for a natural, velvety flush, and sweep on ShadowSense after your eye care for waterproof, crease-resistant color. Using LashExtend? Apply it at the lash base first, before ShadowSense.

  7. Morning · Lashes and brows

    Define lashes and brows

    LashExtend helps lashes appear up to 25% longer, healthier, stronger and fuller over time. Conditioning peptides, humectants and antioxidant botanicals support a more resilient-looking lash line. For the day’s definition, prime with UnderSense® 3-in-1 Maximizing Lash Primer, finish with one LashSense® VolumeIntense® mascara and shape brows with BrowSense®.

  8. All day · Lips

    Lip color that lasts, your way

    LipSense Long-Lasting Liquid Lip Color offers waterproof, kiss-proof, transfer-proof wear for up to 18 hours. Build three thin layers on clean, dry lips, then seal with compatible Moisturizing Gloss. Layer up to three shades. Create your own.

    Prefer one step? LipSense® Cream (formerly HydraMatte) is waterproof and transfer-resistant, with wear lasting up to six hours from one layer, based on our internal panelist study.

  9. Evening · Removal

    Remove the day, gently

    A clear blue bottle with a dark blue cap, Fooops!® Dual Phase Color Remover.

    Fooops!® Dual Phase Color Remover lifts face and eye color, including waterproof mascara, and LipSense® Ooops!™ Lip Color Remover dissolves LipSense color in a few gentle swipes. For a full-face first cleanse, Melt-Away Deep Cleansing Balm melts makeup away before your cleanser.

  10. Evening · Treat and restore

    Return to evening care

    Pump Climate Control onto the back of your hand and palette it over face and neck, apply your chosen treatment and finish with your Evening Moisturizer. Advanced SenePlex+® Renewal Serum with Retinol is the evening renewal option: start every other night and build to nightly as your skin tolerates it. Collagen Firming Night Pak then seals the routine as the final evening step after moisturizer.

  11. Weekly and as needed

    Extend the care: weekly, scalp and body

    Twice a week or as needed, Facial Resurfacer polishes with Vanuatu Volcanic Ash and walnut shell powder for a smoother, more radiant-looking finish. Two to three times a week, Detoxifying Oxygen Facial Mask turns from a silky gel into a foam of tiny oxygenating bubbles, with Kaolin clay, fruit-derived AHA exfoliation and Rhodiola for a more even, radiant-looking complexion before your routine.

    For the scalp, choose HairBalance® to clear buildup and balance oil-prone roots, HairCovery® for fuller-looking density or HairPlenish® for dry, frizz-prone hair. Body Butter, Advanced Hydration Body Lotion and Climate Control Body Recovery Mist carry moisture care beyond the face.

Each color formula keeps its own wear duration; the 24-hour philosophy describes the connected routine.

Every technology, in one routine

Each SeneGence technology has a place in your day. Follow it to the formulas that carry it.

SenePlex+®

From Climate Control and the Trio to your moisturizers and eye care, then on into foundations and shadows, blush and highlighter.

Meet SenePlex+® and its two orchids
Six true extremophiles, one for each extreme

SenePlex+®, our foundational proprietary anti-aging complex at work in most of our products, is our extremophile technology, and our formulas also carry six true extremophiles, one for each extreme: Swiss glacier bacteria extract, Succinic Acid (with Maltodextrin) on the label, in Digital Age Defense Serum; deep-sea vent Alteromonas Ferment Extract in Climate Control Body Recovery Mist; Bacillus Ferment from Spain’s acidic Rio Tinto in 3 in 1 Cleanser - Normal to Oily, DayTime Moisturizer – Normal to Oily and Evening Moisturizer – Normal to Oily, and in the Normal-Oily SkinCare Regimen Set; a different Bacillus Ferment from the Es Trenc salt flats of Mallorca in NeoTight™ Eye Serum; Spirulina Maxima (Algae) Extract, from spirulina, the blue-green alga that thrives in alkaline soda lakes, in SeneSerum-C® Hydrating C-Pearls® Serum, Fooops!® Dual Phase Color Remover, select shades of MakeSense® Color Correcting Tinted Moisturizer and select shades of MakeSense® Original Foundation; and the resurrection plant, Myrothamnus Flabellifolia (Resurrection) Leaf/Stem Extract, in DayTime Moisturizer – Dry and the Dry SkinCare Regimen Set.

Meet the ingredients and their origins
Plant exosomes

Centella Asiatica Leaf Vesicles in GLP Complex™, morning and evening.

Meet GLP Complex
Peptides

Treatment, moisture, primer, powder, lashes and brows, each with its own exact peptide.

Find your peptide
Microbiome care

The Microbiome Collection from cleanse to night, and Glowify® Microbiome Serum Primer under makeup.

Explore microbiome care
Biomimetic lipid care

Nangai Oil, after your treatments and before moisturizer, when skin wants more softness and comfort.

Meet Nangai Oil
Vitamin C and retinol

SeneSerum-C® Hydrating C-Pearls® Serum in the morning; on retinol nights, keep it morning only and use Advanced SenePlex+® Renewal Serum with micro-encapsulated Retinol in the evening.

Explore evening renewal
Skincare inside long-wear color

SenePlex+® in foundation, blush, shadow and highlighter, beside LipSense® color built to last.

Bring skincare into your color
Clean Beauty, 24/7

Every step formulated to the European Union cosmetic standard.

See the standard
Orchid secretomes

SenePlex+® orchid stem cell secretomes, with more secretomes coming from the same orchid legend.

On the horizon

Resilience, from nature to your routine

Morning to night · Every step

SenePlex+®, inspired by a caldera orchid

Our proprietary SenePlex+® technology connects gentle-looking surface renewal with hydration and comfort. The orchid of the Mount Yasur caldera inspired SenePlex+®, which carries two orchids: Calanthe Discolor (Ebine) Extract, the orchid stem cells, and Orchis Mascula (Orchid) Flower Extract.

Joni Rogers-Kante found that orchid on her search for extremophile organisms in Vanuatu. Today the two orchids support resilient-looking skin, yeast-and-kelp bioferment enzymes bring a gently renewed look, and prickly pear with humectants adds moisture and comfort.

Joni Rogers-Kante, founder of SeneGence, sifting volcanic ash at Mount Yasur in Vanuatu
Joni Rogers-Kante sifting volcanic ash at Mount Yasur in Vanuatu.

Morning and evening · Treat

Lightweight hydration, a resilient-looking finish

A cream concentrate bottle with a blue orchid-decorated cap, SeneCell™ SenePlex+® StemCell Concentrate.

SeneCell™ SenePlex+® StemCell Concentrate includes orchid stem cells (Calanthe discolor) in a lightweight morning-and-evening serum for immediate and lasting hydration and visibly firmer, lifted-looking skin.

Smooth two pumps over clean face and neck, morning and night, before moisturizer; in the Triple Cell Renewal Trio it follows GLP Complex™.

In an independent study, SeneCell improved measured skin hydration by a mean 73.9% immediately after application.

Essex Testing Clinic; 31 participants; measured by Corneometer.

Calanthe Discolor (Ebine) Extract

Meet the orchid stem cells SenePlex+® carries beside its second orchid, Orchis Mascula (Orchid) Flower Extract, then see how SeneCell™, NeoTight™ Eye Serum and EyeCrème bring both orchids into different textures and jobs.

Calanthe: exact identity & SenePlex+ role

Six true extremophiles, the ingredients carrying the Mount Yasur story, and hardy botanicals in distinct bands.
SenePlex+®, our foundational proprietary anti-aging complex at work in most of our products, is our extremophile technology, and our formulas also carry six true extremophiles, one for each extreme: Swiss glacier bacteria extract, Succinic Acid (with Maltodextrin) on the label, in Digital Age Defense Serum; deep-sea vent Alteromonas Ferment Extract in Climate Control Body Recovery Mist; Bacillus Ferment from Spain’s acidic Rio Tinto in 3 in 1 Cleanser - Normal to Oily, DayTime Moisturizer – Normal to Oily and Evening Moisturizer – Normal to Oily, and in the Normal-Oily SkinCare Regimen Set; a different Bacillus Ferment from the Es Trenc salt flats of Mallorca in NeoTight™ Eye Serum; Spirulina Maxima (Algae) Extract, from spirulina, the blue-green alga that thrives in alkaline soda lakes, in SeneSerum-C® Hydrating C-Pearls® Serum, Fooops!® Dual Phase Color Remover, select shades of MakeSense® Color Correcting Tinted Moisturizer and select shades of MakeSense® Original Foundation; and the resurrection plant, Myrothamnus Flabellifolia (Resurrection) Leaf/Stem Extract, in DayTime Moisturizer – Dry and the Dry SkinCare Regimen Set. Four of our ingredients carry the Mount Yasur story: Volcanic Ash, selected about 1.5 km downwind of Mount Yasur’s active vent, which polishes in Facial Resurfacer; Calanthe Discolor (Ebine) Extract, our orchid stem cells, at work in 48 SeneGence products; Orchis Mascula (Orchid) Flower Extract, SenePlex+®'s second orchid; and Canarium Indicum (Nangai) Seed Oil, from the Nangai tree that evolved an oil to seal and protect against volcanic heat, which leads Nangai Oil. Chlamydomonas Reinhardtii Extract comes from a green alga known for thriving in extreme environments, even snow; in Collagen Firming Night Pak, its algae-derived lipids replenish hydration and improve luminosity. Collagen Firming Night Pak pairs Sea Water with microalgae grown in harsh arctic conditions; this microalgae and mineral-rich seawater complex helps seal in moisture and supports skin firmness. Rhodiola Rosea Root Extract comes from golden root, a plant native across subarctic and subalpine regions; in Detoxifying Oxygen Facial Mask, it supports skin’s natural defenses against harsh environmental factors and helps the complexion look more even and radiant.

Six true extremophiles, one for each extreme

SenePlex+®, our foundational proprietary anti-aging complex at work in most of our products, is our extremophile technology, and our formulas also carry six true extremophiles, one for each extreme: Swiss glacier bacteria extract, Succinic Acid (with Maltodextrin) on the label, in Digital Age Defense Serum; deep-sea vent Alteromonas Ferment Extract in Climate Control Body Recovery Mist; Bacillus Ferment from Spain’s acidic Rio Tinto in 3 in 1 Cleanser - Normal to Oily, DayTime Moisturizer – Normal to Oily and Evening Moisturizer – Normal to Oily, and in the Normal-Oily SkinCare Regimen Set; a different Bacillus Ferment from the Es Trenc salt flats of Mallorca in NeoTight™ Eye Serum; Spirulina Maxima (Algae) Extract, from spirulina, the blue-green alga that thrives in alkaline soda lakes, in SeneSerum-C® Hydrating C-Pearls® Serum, Fooops!® Dual Phase Color Remover, select shades of MakeSense® Color Correcting Tinted Moisturizer and select shades of MakeSense® Original Foundation; and the resurrection plant, Myrothamnus Flabellifolia (Resurrection) Leaf/Stem Extract, in DayTime Moisturizer – Dry and the Dry SkinCare Regimen Set.

Morning · Moisturize

DayTime Dry · Resurrection plant

Moisture care for stressed-looking skin

Myrothamnus Flabellifolia (Resurrection) Leaf/Stem Extract comes from the resurrection plant, which survives near-total drying on rock outcrops in southern Africa and revives when water returns; it hydrates, protects and revitalizes stressed skin in DayTime Moisturizer – Dry, also part of the Dry SkinCare Regimen Set.

Resurrection plant

See how living Myrothamnus leaves fold during severe drying, then meet the exact leaf-and-stem extract in DayTime Moisturizer - Dry and its hydration, protection, and stressed-skin support.

Resurrection plant: biology, INCI & routine

Morning and evening · Cleanse and moisturize

Normal to Oily skincare · Rio Tinto Bacillus Ferment

Rehydrated, firmer-looking skin, from an acid river

The Normal to Oily skincare carries Bacillus Ferment from an acid-loving microorganism sampled from Spain’s Rio Tinto, the acidic, iron-rich river astrobiologists call “Mars on Earth”; it helps rehydrate skin, minimize water loss and give skin a firmer-looking appearance in 3 in 1 Cleanser - Normal to Oily, DayTime Moisturizer – Normal to Oily and Evening Moisturizer – Normal to Oily, which come together in the Normal-Oily SkinCare Regimen Set.

Morning and evening · Treat

Digital Age Defense Serum · Swiss glacier bacteria

Energized-looking skin, from beneath a Swiss glacier

In Digital Age Defense Serum, Swiss glacier bacteria extract, Succinic Acid (with Maltodextrin) on the label, helps support ATP production for energized-looking skin. The extract begins with Iodobacter, a cold-tolerant bacterium found in soil beneath a glacier in Valais, Switzerland, and reawakened after many years dormant under the ice.

Morning and evening · Eye care

NeoTight™ Eye Serum · Salt-flat Bacillus Ferment

A smoother, brighter-looking eye area, from the salt flats

NeoTight™ Eye Serum’s Bacillus Ferment comes from a salt-tolerant bacterium that lives inside a salt-marsh plant on the salt flats of Es Trenc, Mallorca; this marine biotech helps reduce the look of crow’s feet, dark circles and under-eye bags. It shares its label name with the Normal to Oily ferment, yet it comes from a different organism with its own origin.

Morning care, color and evening removal

Spirulina, the alga of alkaline soda lakes

Spirulina Maxima (Algae) Extract comes from spirulina, the blue-green alga that thrives in hot soda lakes as alkaline as pH 9 to 11. Rich in vitamins and minerals, it helps tone, hydrate and smooth skin and helps brighten and protect the complexion in Fooops!® Dual Phase Color Remover, SeneSerum-C® Hydrating C-Pearls® Serum, select shades of MakeSense® Color Correcting Tinted Moisturizer and select shades of MakeSense® Original Foundation.

Explore spirulina and its products

Ingredients from the world’s hardest places

Evening · Treat

Collagen Firming Night Pak · Snow alga and arctic microalgae

Sealed-in moisture and luminosity, by morning

Chlamydomonas Reinhardtii Extract comes from a green alga known for thriving in extreme environments, even snow; in Collagen Firming Night Pak, its algae-derived lipids replenish hydration and improve luminosity.

Collagen Firming Night Pak pairs Sea Water with microalgae grown in harsh arctic conditions; this microalgae and mineral-rich seawater complex helps seal in moisture and supports skin firmness.

Before skincare · Mask

Detoxifying Oxygen Facial Mask · Subarctic Rhodiola

A more even, radiant-looking complexion

Rhodiola Rosea Root Extract comes from golden root, a plant native across subarctic and subalpine regions; in Detoxifying Oxygen Facial Mask, it supports skin’s natural defenses against harsh environmental factors and helps the complexion look more even and radiant.

Around it, the mask turns from a silky gel into a foam of tiny oxygenating bubbles, with Kaolin, a white clay, to draw out impurities and fruit-derived AHA exfoliation from bilberry, sugar cane, orange, lemon and sugar maple extracts. Use it two to three times a week.

In a four-week clinical study of 33 women, measured by expert observation and instrument analysis compared with baseline, Detoxifying Oxygen Facial Mask increased skin hydration immediately, with an average 35% improvement after 72 hours, and improved exfoliation to remove dead skin cells by an average of 38% after four weeks, when 97% of participants had improved exfoliation.

Rhodiola in the oxygen mask

Trace Rhodiola rosea from its subarctic and subalpine native range to Rhodiola Rosea Root Extract in Detoxifying Oxygen Facial Mask, then follow the three-to-five-minute mask method.

Rhodiola: root extract, mask & next steps

Four ingredients carry the Mount Yasur story

Four of our ingredients carry the Mount Yasur story: Volcanic Ash, selected about 1.5 km downwind of Mount Yasur’s active vent, which polishes in Facial Resurfacer; Calanthe Discolor (Ebine) Extract, our orchid stem cells, at work in 48 SeneGence products; Orchis Mascula (Orchid) Flower Extract, SenePlex+®'s second orchid; and Canarium Indicum (Nangai) Seed Oil, from the Nangai tree that evolved an oil to seal and protect against volcanic heat, which leads Nangai Oil.

Weekly and as needed

Facial Resurfacer · Mount Yasur volcanic ash

A smoother, more radiant-looking polish

Volcanic Ash comes from Vanuatu, where SeneGence selects it near Mount Yasur, an active volcano on the island of Tanna; in Facial Resurfacer, its mineral-rich texture exfoliates and polishes without irritation. Walnut shell powder works beside it for a smoother, more radiant-looking finish.

Vanuatu volcanic ash

Follow the mineral selected approximately 1.5 kilometers downwind of Mount Yasur into Facial Resurfacer, where it works with walnut shell powder for controlled physical polishing.

Volcanic ash: selection & exfoliation

Choose the care that fits your goal

Morning and evening · Treat

Visibly restored facial volume and smoother-looking skin, with GLP Complex

In an independent study, GLP Complex™ with SenePlex+® and Exosomes reduced the appearance of deep wrinkles by 23.4% at eight weeks.

Essex Testing Clinic; 31 participants; image analysis. This is a result for the complete serum.

GLP Complex serum bottle on blue water, labeled Glow Lipids Peptides with SenePlex+ and Exosomes
GLP Complex™ with SenePlex+® and Exosomes.

GLP Complex™ with SenePlex+® and Exosomes is a morning-and-evening facial serum that visibly restores lost facial volume, smooths deep wrinkles and firms skin affected by aging, weight loss and lifestyle changes. Its formula pairs Centella Asiatica Leaf Vesicles with Caprooyl Tetrapeptide-3 and the lipid ingredients Phospholipids and Glycolipids.

Ornithine HCl joins those Phospholipids and Glycolipids for natural-looking facial volume. In the Triple Cell Renewal Trio, GLP Complex follows Climate Control and comes before SeneCell™.

Morning and evening · Cleanse to moisturize

Comfort, from cleansing to evening care

The Microbiome Collection gives each part of your skincare day its own formula: a comfortable cleanse, lightweight hydration, daytime moisture with SPF 15 and richer care for night.

Microbiome Correcting Cleanser

A clean, comfortable rinse. Mild cleansers meet pomegranate ferment and Streptococcus Thermophilus Ferment.

Microbiome Boosting Serum

Lightweight morning-and-evening hydration. Lactobacillus Ferment supports a supple feel alongside water-binding Sodium Hyaluronate, Hyaluronic Acid and Sodium Hyaluronate Crosspolymer.

Microbiome Defense Daytime Moisturizer SPF 15

Daytime moisture with labeled broad-spectrum SPF 15. Lactobacillus Ferment, Saccharomyces Ferment Filtrate and Sodium Hyaluronate bring moisture care.

Microbiome Restorative Evening Moisturizer

Richer softness and barrier comfort. Lactobacillus Ferment joins Ceramide NP, Cholesterol and Squalane for supple-feeling skin, moisture-barrier support and softness.

Two companions complete the picture: pump Climate Control onto the back of your hand after cleansing and palette it over face and neck, and smooth Glowify® Microbiome Serum Primer, with its own Lactobacillus Ferment, under makeup.

The Microbiome Skincare Regimen Set includes EyeCrème; Microbiome Boosting Serum is sold separately.

Morning and evening · After treatments

Softness, inspired by skin’s own lipids

Nangai Oil seals moisture, softens the look of fine lines and replenishes skin’s oil balance. Its botanical skin-lipid mimetic combines Jojoba Oil/Macadamia Seed Oil Esters, Squalene, Phytosteryl Macadamiate and Phytosterols.

Biomimetic means biological mimicry: Nangai Oil’s skin-lipid mimetic blend imitates the skin’s own lipids. Add Nangai Oil when your skin wants the extra softness and comfort of lipid care. Smooth it on after your treatments and before moisturizer.

Nangai Oil

See why Canarium Indicum Seed Oil and complementary lipids belong after treatments and before moisturizer when dry, tight, or depleted-feeling skin wants lipid comfort.

Nangai Oil: formula, fit & order

Morning and evening · Treat

Vitamin-C care in SeneSerum-C Hydrating C-Pearls Serum

Meet Tetrahexyldecyl Ascorbate, the vitamin-C ingredient in SeneSerum-C Hydrating C-Pearls Serum. Explore its own ingredient research within this named skincare formula.

Evening · Treat

Evening renewal, with micro-encapsulated retinol

For brighter, firmer-looking skin and less noticeable fine lines over time, Advanced SenePlex+® Renewal Serum with Retinol pairs retinol with moisture care. Its retinol is micro-encapsulated for sustained release, rambutan leaf extract complements it, and meadowfoam seed oil, aloe and hyaluronates bring hydration and a calmer feel.

Start every other night and build to nightly as your skin tolerates it, then follow with Evening Moisturizer. By day, wear a broad-spectrum sunscreen of at least SPF 15 and avoid sun exposure while you use it. Microbiome Defense Daytime Moisturizer SPF 15 is SeneGence’s broad-spectrum SPF 15 (Beauty Book 2026, p. 13).

Nephelium Lappaceum (rambutan) Leaf Extract has research of its own: the ingredient’s maker reports that a test formula with 0.1% of its prepared rambutan leaf material improved skin elasticity and reduced crow’s-feet measurements from baseline in a 28-day split-face study.

The serum also carries five recombinant factors and a Palmitoyl peptide pair; meet them in the peptide guide below.

Morning and evening · Moisturize

Moisture with a signature for every skin type

All six DayTime and Evening Moisturizers share the two-peptide tone pair, and the three DayTime formulas add Bis(Tripeptide-1) Copper Acetate for firming and line care. Each skin type then has its own signature.

In a 20-day independent clinical study of 33 women ages 19–65, measured by expert clinical grading compared with baseline, Evening Moisturizer – Normal to Dry with SenePlex+® and orchid stem cells accelerated skin cell renewal by 35.7%.

Dry

3 in 1 Cleanser - Dry, DayTime Moisturizer - Dry and Evening Moisturizer - Dry carry Aspergillus Ferment, a fermentation-derived skin conditioner. A brown-rice Aspergillus Ferment blend has been studied for a softer look to wrinkles; that research describes its own tested preparation.

Normal to Dry

Ganoderma Lucidum mushroom-stem extract belongs to both Normal-to-Dry moisturizers. Evening highlights its youthful, lifted-looking care, alongside mangosteen fruit extract’s antioxidant role.

Normal to Oily

3 in 1 Cleanser, DayTime Moisturizer and Evening Moisturizer - Normal to Oily share a Bacillus Ferment from Spain’s Rio Tinto. DayTime Moisturizer - Normal to Oily brings it into hydration with a more matte-looking T-zone.

Every skin type, overnight

Collagen Firming Night Pak is the final evening treatment after moisturizer. Its marine-based formula brings Jania Rubens Extract, a red seaweed; Chlamydomonas Reinhardtii Extract, a snow-hardy green alga; and Sea Water with arctic-grown microalgae, plus Nangai Oil and soothing botanicals, to help lock in moisture for a firmer, smoother-looking complexion by morning.

In the Night Pak, Lactobacillus Ferment Lysate brings conditioning care for a less flaky look and a more supple feel.

Morning to night · Treat, prime and define

Find your peptide by care goal

A smoother-looking line, more even-looking tone or fuller-looking lashes begins with the exact peptide and the formula around it. Caprooyl Tetrapeptide-3 appears in GLP Complex™, SeneCell™ and MakeSense® Silk Primer & Pore Minimizer—bringing peptide care into both treatment and makeup preparation.

Explore the portfolio by care goal, with the ingredient’s research beside the formulas that contain it.

Smoother-looking lines and firming care

Caprooyl Tetrapeptide-3 with Dextran

For smoother-looking lines and firmer-looking skin, look for Caprooyl Tetrapeptide-3 with Dextran in GLP Complex™ with SenePlex+® and Exosomes, SeneCell™ SenePlex+® StemCell Concentrate, and MakeSense® Silk Primer & Pore Minimizer.

Choose by routine job: GLP Complex for targeted care of deep wrinkles and the look of facial volume, SeneCell for concentrated hydration, or Silk Primer for a smoother-looking base before complexion makeup.

Formula and declared peptide ingredients

Each formula below declares Caprooyl Tetrapeptide-3; with Dextran.

Studied preparation

Preparation listed in the research source: Glycerin, Water, Dextran, Caprooyl Tetrapeptide-3.

Plant-Produced Peptide Night Care

For smoother, firmer, more radiant-looking night care, look for Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76 in the current US formulas of Evening Moisturizer - Dry, Evening Moisturizer - Normal to Dry and Evening Moisturizer - Normal to Oily.

This fusion peptide begins in plants: the ingredient manufacturer produces it through Nicotiana benthamiana biotechnology and vertical farming. You will find it in three US night creams—Evening Moisturizer - Dry, Evening Moisturizer - Normal to Dry and Evening Moisturizer - Normal to Oily—so choose the texture for your skin type.

Formula and declared peptide ingredients

Each formula below declares Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76.

  • Evening Moisturizer - Dry
  • Evening Moisturizer - Normal to Dry
  • Evening Moisturizer - Normal to Oily
Studied preparation

Preparation listed in the research source: Water, Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76.

Five Recombinant Factors in Advanced Renewal

For multi-factor smoothing and visible renewal, Advanced SenePlex+® Renewal Serum with Retinol combines sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-9, and sh-Polypeptide-11.

Choose this evening facial treatment when you want retinol, the five-factor complex, and a separate Palmitoyl peptide pair in one visible-renewal formula.

Formula and declared peptide ingredients
Advanced SenePlex+® Renewal Serum with Retinol
sh-Oligopeptide-1; sh-Oligopeptide-2; sh-Polypeptide-1; sh-Polypeptide-11; sh-Polypeptide-9.
Studied preparation

Preparation listed in the research source: Water, Lecithin, Acetyl Glutamine, sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-9, sh-Polypeptide-11, Bacillus/Folic Acid Ferment Extract, Sodium Hyaluronate, Caprylyl Glycol, Butylene Glycol, 1,2-Hexanediol.

Expression-Line Peptide in NeoTight Rejuvenating

For softer-looking expression lines and smoother, less shiny-looking skin, NeoTight® Rejuvenating Anti-Wrinkle Serum contains Dipeptide Diaminobutyroyl Benzylamide Diacetate.

Formula and declared peptide ingredients
NeoTight® Rejuvenating Anti-Wrinkle Serum
Dipeptide Diaminobutyroyl Benzylamide Diacetate.
Studied preparation

Preparation listed in the research source: Dipeptide Diaminobutyroyl Benzylamide Diacetate.

Copper Peptide in DayTime Moisturizers

For firming and line care in daytime moisture, look for Bis(Tripeptide-1) Copper Acetate in DayTime Moisturizer - Dry, DayTime Moisturizer - Normal to Dry, and DayTime Moisturizer - Normal to Oily.

Choose one DayTime texture for your skin: richer comfort for Dry, balanced hydration for Normal to Dry, or hydration with a more matte T-zone for Normal to Oily.

A second copper form works in a different formula: NeoTight® Rejuvenating Anti-Wrinkle Serum pairs Copper Lysinate/Prolinate with Methylglucoside Phosphate, beside Porphyridium Cruentum Extract and its expression-line peptide.

Formula and declared peptide ingredients

Each formula below declares Bis(Tripeptide-1) Copper Acetate.

  • DayTime Moisturizer - Dry
  • DayTime Moisturizer - Normal to Dry
  • DayTime Moisturizer - Normal to Oily
Studied preparation

Preparation listed in the research source: Bis(Tripeptide-1) Copper Acetate.

More even-looking tone

The Two-Peptide Tone Pair

For more even-looking tone and lighter-looking dark spots, look for Palmitoyl sh-Octapeptide-24 Amide with Palmitoyl sh-Tripeptide-5 Norisoleucyl sh-Nonapeptide-1.

You will find the pair in DayTime Moisturizer - Dry, DayTime Moisturizer - Normal to Dry, DayTime Moisturizer - Normal to Oily, Evening Moisturizer - Dry, Evening Moisturizer - Normal to Dry, and Evening Moisturizer - Normal to Oily. Choose among these six US formulas by your skin type, the texture you enjoy and the time of day.

Formula and declared peptide ingredients

Each formula below declares Palmitoyl sh-Octapeptide-24 Amide, Palmitoyl sh-Tripeptide-5 Norisoleucyl sh-Nonapeptide-1.

  • DayTime Moisturizer - Dry
  • DayTime Moisturizer - Normal to Dry
  • DayTime Moisturizer - Normal to Oily
  • Evening Moisturizer - Dry
  • Evening Moisturizer - Normal to Dry
  • Evening Moisturizer - Normal to Oily
Studied preparation

Preparation listed in the research source: Water, Xanthan Gum, Lactic Acid/Glycolic Acid Copolymer, Palmitoyl sh-Octapeptide-24 Amide, Polyvinyl Alcohol, Palmitoyl sh-Tripeptide-5 Norisoleucyl sh-Nonapeptide-1.

Skin and lip-area care

Palmitoyl Tripeptide-1 in Skin and Lip Care

For smoother-looking renewal, Advanced SenePlex+® Renewal Serum with Retinol pairs Palmitoyl Tripeptide-1 with Palmitoyl Tetrapeptide-7.

For hydrated, smoother, fuller-looking lips, LipSense® Long-Lasting Lip Liner Pencil carries Palmitoyl Tripeptide-1 in a separate lip-care context.

Choose by zone and finish: Advanced Renewal is a facial treatment serum, while Lip Liner gives precise definition with conditioning lip care.

Formula and declared peptide ingredients
Advanced SenePlex+® Renewal Serum with Retinol
Palmitoyl Tripeptide-1; Palmitoyl Tetrapeptide-7.
Studied preparation

Skin-care preparation: Glycerin, Water, Butylene Glycol, Carbomer, Polysorbate 20, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7.

Separate lip-care preparation: Ethylhexyl Palmitate, Tribehenin, Sorbitan Isostearate, Palmitoyl Tripeptide-1.

The Lip Line Corrector Peptide Pair

For smoother-looking deep lip-area folds and plumper-looking contours, Lip Line Corrector pairs Palmitoyl Tetrapeptide-50 with Heptapeptide-15 Palmitate.

Use it as the targeted lip-area step when the look of vertical lines and deeper folds beside the mouth leads your choice.

Formula and declared peptide ingredients
Lip Line Corrector
Palmitoyl Tetrapeptide-50; Heptapeptide-15 Palmitate.
Studied preparation

Preparation listed in the research source: Water, Xanthan Gum, Lactic Acid/Glycolic Acid Copolymer, Palmitoyl Tetrapeptide-50, Polyvinyl Alcohol, Heptapeptide-15 Palmitate.

Brows, lashes and hair

Acetyl Tetrapeptide-3 with Clover and Dextran

For fuller-looking brows, lashes, and hair, look for Acetyl Tetrapeptide-3 with Trifolium Pratense (Clover) Flower Extract and Dextran in BrowSense® Volumizing Brow Gel, HairCovery® Strengthening & Thickening Hair Serum, LashSense® VolumeIntense® Mascara, LashSense® VolumeIntense® Waterproof Mascara, and UnderSense® 3-in-1 Maximizing Lash Primer.

Match the format to the beauty goal: BrowSense shapes and holds, HairCovery is the leave-on scalp-serum step, UnderSense primes and builds lashes, and one regular or waterproof VolumeIntense mascara supplies the color finish.

Formula and declared peptide ingredients

Each formula below declares Acetyl Tetrapeptide-3; with Trifolium Pratense (Clover) Flower Extract, Dextran.

Studied preparation

Preparation listed in the research source: Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, Trifolium Pratense (Clover) Flower Extract.

Myristoyl Pentapeptide-17 in LashExtend

For denser, fuller-looking lashes, LashExtend contains Myristoyl Pentapeptide-17.

Choose LashExtend as the dedicated lash-serum format, applied at the lash base morning and evening as directed until the desired result.

Formula and declared peptide ingredients
LashExtend
Myristoyl Pentapeptide-17.
Studied preparation

Preparation listed in the research source: Water, Glycerin, Myristoyl Pentapeptide-17.

Biotinoyl Tripeptide-1 in UnderSense

For longer-, fuller-, stronger-looking lash support, UnderSense® 3-in-1 Maximizing Lash Primer contains Biotinoyl Tripeptide-1.

Apply UnderSense to top and bottom lashes, add coats for more buildable length and volume, and let it fully dry before finishing with one VolumeIntense mascara.

Formula and declared peptide ingredients
Studied preparation

Preparation listed in the research source: Glycerin, Water, Panthenol, Biotinoyl Tripeptide-1.

Oligopeptide-10 and Skin-Clarity Research

UnderSense® 3-in-1 Maximizing Lash Primer also carries Oligopeptide-10, and its ingredient maker reports cosmetic skin-clarity research for this exact peptide.

For the customer routine, UnderSense supplies a light-beige preparation layer, buildable volume and length, and a base for mascara. Let it fully dry before the color finish.

Formula and declared peptide ingredients
Studied preparation

Preparation listed in the research source: Oligopeptide-10.

A soft-focus finishing formula

Acetyl Hexapeptide-8 in Translucent Loose Powder

Translucent Loose Powder creates a soft-focus setting finish. Its formula also includes Acetyl Hexapeptide-8.

Pick up the loose powder with a brush and apply where you want a soft-focus finish.

Formula and declared peptide ingredients
Translucent Loose Powder
Acetyl Hexapeptide-8.
Studied preparation

Preparation listed in the research source: Water, Acetyl Hexapeptide-8, Caprylyl Glycol.

Bring skincare into your color wardrobe

Choose the formula for the look, feel and way you want to wear it—from a smoother-looking makeup base to long-wear lip color with Gloss comfort.

This is where skincare meets long-lasting cosmetics. SenePlex+® carries into our foundations and shadows, blush and highlighter, and each color card below shows the morning skincare step it follows.

Morning · Prime

A lit-from-within base, with microbiome care

Glowify® Microbiome Serum Primer hydrates and conditions skin, supports its barrier and helps balance excess oil, with SenePlex+® in the formula. Lactobacillus Ferment with green tea and Glucosamine HCl brings probiotic ferment care, Niacinamide helps refine the look of pores, and peach mica creates a soft-focus glow that never looks glittery.

In the morning, smooth it over moisturized skin once your skincare is done, then wear it alone or under foundation.

Morning · Complexion

An undertone-aware complexion

A beige foundation bottle with a translucent cobalt-blue cap and base, a gold band and the gold SeneGence S-and-orchid mark, MakeSense® Original Foundation.

MakeSense® Original Foundation is made with 90% skincare ingredients. It uses Adapting Pigment Technology to shift toward your undertone as you blend, and carries SenePlex+® for a brighter, more luminous-looking complexion.

Blend it over clean, moisturized, primed skin in the morning and layer for more coverage. Its water-resistant film-forming polymers help the finish stay fresh.

Morning · Glow

Radiance that cares for skin

A pale pink bottle with a gold orchid-engraved cap and gold base, MakeSense® Pearlizer.

MakeSense® Pearlizer gives skin natural-looking radiance with an oil-free liquid luminizer made with 90% skincare ingredients. It hydrates and helps soften the look of fine lines as it highlights. SenePlex+® is part of its formula, beside moisture-binding Sodium Hyaluronate and soothing aloe.

After your morning base, touch it onto the high points of the face, mix it into foundation, or blend it onto the body.

Morning · Cheeks

Cheek color with skincare inside

A bottle of deep berry-red cream blush with a white collar and a gold orchid-engraved cap, BlushSense® Cream Blush.

BlushSense® Cream Blush is made with 90% skincare ingredients. Its creamy color blends with MakeSense® Foundation for a natural, velvety flush, with long-lasting, water- and smudge-resistant wear. SenePlex+® supports cell renewal and fewer visible signs of aging, while Sodium Hyaluronate and vitamins B and E bring moisture and antioxidant care.

After foundation, apply it to the cheeks, blend, and layer to build intensity.

All day · Lips

Color that lasts, with Gloss comfort

A brick-rose Chai liquid lip-color tube with a smooth gold cap and a thin gold band, LipSense® Long-Lasting Liquid Lip Color.

LipSense Long-Lasting Liquid Lip Color offers waterproof, kiss-proof, transfer-proof wear for up to 18 hours. Its Permeable Polymer Matrix lets compatible Moisturizing Gloss conditioners pass through the color film to the lips beneath.

After your morning skincare, build three thin layers on clean, dry lips and seal with Gloss. Layer up to three shades. Create your own.

You will also find SenePlex+® in Corrective Color Concealer, MakeSense® Contouring Bronzer Cream and Glowify® Long-Lasting Eyeshadow Stick.

Keep choosing with confidence

Every step · 24/7

One formulation standard, morning to night

We formulate to the European Union cosmetic standard, which prohibits 1,700+ substances. We choose that benchmark for ourselves, and every step in this routine is formulated to it: the morning mist, the color you wear through the day and the care you return to at night. That is Clean Beauty, 24/7.

Our formulas are paraben-free. Our topical products are vegan-friendly; wellness products keep their own ingredient guidance.

Keep learning by ingredient, routine or product. Open a complete lesson, compare the evidence, or return to the part of your day you are planning.

Explore every extremophile ingredient and the products that carry it

  1. 01 SenePlex+ Ingredients 6 min · Read →

    SenePlex+® combines orchid stem cells, yeast-and-kelp bioferments, prickly pear and humectants for renewal, firmness, hydration and comfort.

  2. 02 What Peptides Are in SeneGence Products? Exact INCI Guide 16 min · Read →

    Explore 20 exact peptide INCI identities across current SeneGence skin, lip, lash, brow, hair, and makeup formulas, with manufacturer-reported findings.

  3. 03 Botanical, Marine and Exosome Actives in SeneGence 6 min · Read →

    Explore SeneGence botanical extracts, marine hydration ingredients and plant-derived exosomes, the formulas that carry them and what the GLP Complex study found.

  4. 04 How to Layer the SeneGence Triple Cell Renewal Trio 5 min · Read →

    Use the Triple Cell Renewal Trio in order, then pat Nangai Oil on after treatment and before moisturizer when skin feels dry or depleted.

  5. 05 SeneGence Before and After: The Clinical File 8 min · Read →

    Match SeneGence results to the exact product and distinguish NeoTight treatment, EyeCrème moisture, and EyeLuminator makeup brightness.

Clinical results Technology glossary
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